{"id":{"repo_id":"arizona-thes","oai_identifier":"oai:repository.arizona.edu:10150/668240"},"canonical_url":"https://search.dev.ndltd.org/etd/arizona-thes/oai:repository.arizona.edu:10150/668240","repository":{"repo_id":"arizona-thes","name":"University of Arizona","base_url":"https://repository.arizona.edu/oai/request"},"display":{"title":"Adrenergic Mobilization of the Immune System and the Anti-Cancer Effects of Exercise","abstract":"A single bout of exercise has a profound effect on the number and composition of immune cells within the circulation. Within this response, there exists a preferential mobilization of effector lymphocytes with cytotoxic potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative to the specific tumor model. We herein demonstrate that blockade of the β2-AR in humans during exercise significantly blunts the mobilization of lymphocytes, while β1-AR blockade or β1-AR blockade plus PDE4 inhibition significantly augment the mobilization of NK-cells or monocytes, γδ T-cells, and CD8 T-cells, respectively. We provide single cell transcriptomic data to further the understanding of signaling within immune cells during exercise, and demonstrate that isoproterenol infusion in humans mimics the mobilization of NK-cell phenotypes seen during exercise at 70% VO2max. Further, we demonstrate in various murine models of A20 lymphoma that exercise exerts a protective effect on tumor progression, and this effect is dependent upon both β2-AR signaling and NK-cells. We lastly demonstrate that exercising animals present with increased infiltration of cytotoxic lymphocyte populations within tumors, and that these infiltrates correlate with tumor kinetics.","abstract_html":"A single bout of exercise has a profound effect on the number and composition of immune cells within the circulation. Within this response, there exists a preferential mobilization of effector lymphocytes with cytotoxic potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative to the specific tumor model. We herein demonstrate that blockade of the β2-AR in humans during exercise significantly blunts the mobilization of lymphocytes, while β1-AR blockade or β1-AR blockade plus PDE4 inhibition significantly augment the mobilization of NK-cells or monocytes, γδ T-cells, and CD8 T-cells, respectively. We provide single cell transcriptomic data to further the understanding of signaling within immune cells during exercise, and demonstrate that isoproterenol infusion in humans mimics the mobilization of NK-cell phenotypes seen during exercise at 70% VO2max. Further, we demonstrate in various murine models of A20 lymphoma that exercise exerts a protective effect on tumor progression, and this effect is dependent upon both β2-AR signaling and NK-cells. We lastly demonstrate that exercising animals present with increased infiltration of cytotoxic lymphocyte populations within tumors, and that these infiltrates correlate with tumor kinetics.","abstract_has_math":false,"creators":["Smith, Kyle Andrew"],"institution":"The University of Arizona.","degree_name":"Ph.D.","degree_level":"doctoral","degree_discipline":"Graduate College","degree_department":null,"school":null,"contributors":[],"advisors":["Simpson, Richard"],"committee_chairs":[],"committee_members":["Katsanis, Emmanuel","Lynch, Ron","Konhilas, John","Lybarger, Lonnie"],"year":2023,"date_issued":"2023","date_published":"2023","updated_at":"2026-07-24T00:57:10Z","subjects":[],"languages":["en"],"rights":["Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. 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Within this response, there exists a preferential mobilization of effector lymphocytes with cytotoxic potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative to the specific tumor model. We herein demonstrate that blockade of the β2-AR in humans during exercise significantly blunts the mobilization of lymphocytes, while β1-AR blockade or β1-AR blockade plus PDE4 inhibition significantly augment the mobilization of NK-cells or monocytes, γδ T-cells, and CD8 T-cells, respectively. We provide single cell transcriptomic data to further the understanding of signaling within immune cells during exercise, and demonstrate that isoproterenol infusion in humans mimics the mobilization of NK-cell phenotypes seen during exercise at 70% VO2max. Further, we demonstrate in various murine models of A20 lymphoma that exercise exerts a protective effect on tumor progression, and this effect is dependent upon both β2-AR signaling and NK-cells. We lastly demonstrate that exercising animals present with increased infiltration of cytotoxic lymphocyte populations within tumors, and that these infiltrates correlate with tumor kinetics."]},{"key":"dc:title","label":"Title","values":["Adrenergic Mobilization of the Immune System and the Anti-Cancer Effects of Exercise"]}]}],"canonical_facts":{"dc:contributor.advisor":["Simpson, Richard"],"dc:contributor.committeemember":["Katsanis, Emmanuel","Lynch, Ron","Konhilas, John","Lybarger, Lonnie"],"dc:creator":["Smith, Kyle Andrew"],"dc:date.accessioned":["2023-06-11T16:47:57Z"],"dc:date.available":["2023-06-11T16:47:57Z"],"dc:date.issued":["2023"],"dc:description.abstract":["A single bout of exercise has a profound effect on the number and composition of immune cells within the circulation. Within this response, there exists a preferential mobilization of effector lymphocytes with cytotoxic potential, and evidence exists for an anti-tumor effect of exercise dependent upon NK-cells or CD8+ T-cells relative to the specific tumor model. We herein demonstrate that blockade of the β2-AR in humans during exercise significantly blunts the mobilization of lymphocytes, while β1-AR blockade or β1-AR blockade plus PDE4 inhibition significantly augment the mobilization of NK-cells or monocytes, γδ T-cells, and CD8 T-cells, respectively. We provide single cell transcriptomic data to further the understanding of signaling within immune cells during exercise, and demonstrate that isoproterenol infusion in humans mimics the mobilization of NK-cell phenotypes seen during exercise at 70% VO2max. Further, we demonstrate in various murine models of A20 lymphoma that exercise exerts a protective effect on tumor progression, and this effect is dependent upon both β2-AR signaling and NK-cells. 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