{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/8652"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/8652","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"hs-CRP level represents the disease burden and the age but not vulnerability of coronary atherosclerosis","abstract":"BACKGROUND: hs-CRP (high sensitive C-reactive protein) has been known as a systemic inflammatory marker of atherosclerosis and considered as one of the predictors of future cardiac events. Some reports presented hs-CRP level was associated with plaque vulnerability but most studies were performed by assessing focal target plaque but not whole plaques from a coronary tree. METHODS: To evaluate of the relationship of plasma hs-CRP level and volumetric plaque composition of the coronary arterial tree, we performed ‘whole vessel” virtual histology-intravascular ultrasound (VH-IVUS) in 189 vessels of 63 patients. The components of atherosclerosis were classified as fibrous (FI), fibrous-fatty (FF), necrotic core (NC) and dense calcium (DC). Quantitative assessment of these plaque components and the presence of VH-IVUS–derived thin-cap fibroatheroma (VH-TCFA) in the coronary arterial trees were compared to hs-CRP levels in individuals. hs-CRP levels were measured before coronary angiogram and IVUS study. RESULTS: Forty-nine patients (77.8%) were diagnosed with acute coronary syndrome in this population. The mean values of hs-CRP were 0.24±0.52 mg/dl (0~3.27mg/dl). The analyzed vessel length was 56.1±17.4 mm for the left anterior descending coronary artery, 51.9±19.0 mm for the left circumflex coronary artery, and 74.2±18.8 mm for the right coronary artery. The number of VH-TCFAs was 1.0±0.8 for the left anterior descending, 0.6±0.7 for the left circumflex, and 0.8±1.0 for the right coronary arteries.The hs-CRP levels were positively correlated to mean plaque burden, total plaque volume index, volume index of FF and DC. But parameters of NC and the number of VH-TCFA were not related with hs-CRP level. In multivariate analysis, the volume index of DC was most reliable factor to hs-CRP (β=3.646, CI=2.036 to 5.255, p<0.001) CONCLUSIONS: This three-vessel VH-IVUS presented that hs-CRP were related to the total atherosclerotic burden and the maturing (coronary calcium) but not vulnerable features (NC or VH-TCFA) of plaques in coronary arterial tree. Increased hs-CRP level as a biomarker to predict cardiovascular events might imply atherosclerosis severity of whole coronary tree but not current plaque vulnerability.","abstract_html":"BACKGROUND: hs-CRP (high sensitive C-reactive protein) has been known as a systemic inflammatory marker of atherosclerosis and considered as one of the predictors of future cardiac events. Some reports presented hs-CRP level was associated with plaque vulnerability but most studies were performed by assessing focal target plaque but not whole plaques from a coronary tree. METHODS: To evaluate of the relationship of plasma hs-CRP level and volumetric plaque composition of the coronary arterial tree, we performed ‘whole vessel” virtual histology-intravascular ultrasound (VH-IVUS) in 189 vessels of 63 patients. The components of atherosclerosis were classified as fibrous (FI), fibrous-fatty (FF), necrotic core (NC) and dense calcium (DC). Quantitative assessment of these plaque components and the presence of VH-IVUS–derived thin-cap fibroatheroma (VH-TCFA) in the coronary arterial trees were compared to hs-CRP levels in individuals. hs-CRP levels were measured before coronary angiogram and IVUS study. RESULTS: Forty-nine patients (77.8%) were diagnosed with acute coronary syndrome in this population. The mean values of hs-CRP were 0.24±0.52 mg/dl (0~3.27mg/dl). The analyzed vessel length was 56.1±17.4 mm for the left anterior descending coronary artery, 51.9±19.0 mm for the left circumflex coronary artery, and 74.2±18.8 mm for the right coronary artery. The number of VH-TCFAs was 1.0±0.8 for the left anterior descending, 0.6±0.7 for the left circumflex, and 0.8±1.0 for the right coronary arteries.The hs-CRP levels were positively correlated to mean plaque burden, total plaque volume index, volume index of FF and DC. But parameters of NC and the number of VH-TCFA were not related with hs-CRP level. In multivariate analysis, the volume index of DC was most reliable factor to hs-CRP (β=3.646, CI=2.036 to 5.255, p&lt;0.001) CONCLUSIONS: This three-vessel VH-IVUS presented that hs-CRP were related to the total atherosclerotic burden and the maturing (coronary calcium) but not vulnerable features (NC or VH-TCFA) of plaques in coronary arterial tree. Increased hs-CRP level as a biomarker to predict cardiovascular events might imply atherosclerosis severity of whole coronary tree but not current plaque vulnerability.","abstract_has_math":false,"creators":["박, 세준"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["탁, 승제","대학원 의학과","200624544"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-12-19","date_published":"2013-12-19","updated_at":"2026-07-24T00:51:44Z","subjects":["high sensitive C-reactive protein","hs-CRP","coronary atherosclerosis","virtual histology","intravascular ultrasound","vulnerable plaque","vulnerability","관상동맥경화증","혈관내 초음파","죽상반 취약성"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014769","000000014769"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014769","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014769","code":true},{"text":"000000014769","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/8652","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["탁, 승제","대학원 의학과","200624544","박, 세준"]},{"key":"dc:creator","label":"Author","values":["박, 세준"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2013-12-19","2013"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["high sensitive C-reactive protein","hs-CRP","coronary atherosclerosis","virtual histology","intravascular ultrasound","vulnerable plaque","vulnerability","관상동맥경화증","혈관내 초음파","죽상반 취약성"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/8652","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014769","000000014769"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["BACKGROUND: hs-CRP (high sensitive C-reactive protein) has been known as a systemic inflammatory marker of atherosclerosis and considered as one of the predictors of future cardiac events. Some reports presented hs-CRP level was associated with plaque vulnerability but most studies were performed by assessing focal target plaque but not whole plaques from a coronary tree. METHODS: To evaluate of the relationship of plasma hs-CRP level and volumetric plaque composition of the coronary arterial tree, we performed ‘whole vessel” virtual histology-intravascular ultrasound (VH-IVUS) in 189 vessels of 63 patients. The components of atherosclerosis were classified as fibrous (FI), fibrous-fatty (FF), necrotic core (NC) and dense calcium (DC). Quantitative assessment of these plaque components and the presence of VH-IVUS–derived thin-cap fibroatheroma (VH-TCFA) in the coronary arterial trees were compared to hs-CRP levels in individuals. hs-CRP levels were measured before coronary angiogram and IVUS study. RESULTS: Forty-nine patients (77.8%) were diagnosed with acute coronary syndrome in this population. The mean values of hs-CRP were 0.24±0.52 mg/dl (0~3.27mg/dl). The analyzed vessel length was 56.1±17.4 mm for the left anterior descending coronary artery, 51.9±19.0 mm for the left circumflex coronary artery, and 74.2±18.8 mm for the right coronary artery. The number of VH-TCFAs was 1.0±0.8 for the left anterior descending, 0.6±0.7 for the left circumflex, and 0.8±1.0 for the right coronary arteries.The hs-CRP levels were positively correlated to mean plaque burden, total plaque volume index, volume index of FF and DC. But parameters of NC and the number of VH-TCFA were not related with hs-CRP level. In multivariate analysis, the volume index of DC was most reliable factor to hs-CRP (β=3.646, CI=2.036 to 5.255, p<0.001) CONCLUSIONS: This three-vessel VH-IVUS presented that hs-CRP were related to the total atherosclerotic burden and the maturing (coronary calcium) but not vulnerable features (NC or VH-TCFA) of plaques in coronary arterial tree. Increased hs-CRP level as a biomarker to predict cardiovascular events might imply atherosclerosis severity of whole coronary tree but not current plaque vulnerability.","목적: hs-CRP (high sensitive C-reactive protein)는 동맥경화증의 염증 표지자로 알려져 있으며, 심혈관 질환의 예후를 예측하는 인자로도 인식되고 있다.몇몇 연구들을 통해 hs-CRP 수치가 죽상반의 취약성과 연관이 있다고 밝히고 있지만, 이들 대부분은 관상동맥 전체가 아닌 국소적인 죽상반에 대한 연구로써 그 한계점을 가지고 있다. 방법: 63명의 환자들의 총 189개의 혈관에 대해서 가장조직-혈관내초음파를 시행하여 분석한 죽상반결과를 혈중 hs-CRP 수치와 비교 분석하였다. 가상조직 혈관내초음파는죽상반의 성분을 fibrous, fibrofatty, necrotic core, dense calicum으로4개의 색을 통해 구별하였고, 죽상반의 양적 분석 결과 및 thin cap fibroatheroma(VH-TCFA)유무도 hs-CRP와 수치와 비교하였다. 혈중 hs-CRP는 혈관내 초음파 및 관상동맥 조영술 전에 채혈하였다. 결과: 급성 관동맥 증후군은 전체 환자 중49명(77.8%)이였다.혈중 hs-CRP 수치는 평균 0.24±0.52 mg/dl (0~3.27mg/dl)이였고, 혈관의 길이는 각각 좌전하행지56.1±17.4 mm,좌회선지 51.9±19.0 mm, 우관상동맥74.2±18.8 mm였다. VH-TCFAs는 평균적으로 좌전하행지 1.0±0.8개, 좌회선지 0.6 ±0.7개, 우관상동맥0.8±1.0개가 존재하였다.혈중 hs-CRP 수치는 평균 죽상반 양, 총 죽상반 양, fibrofatty 및 dense calcium의 양적 지수와 양의 상관관계를 보였다. 그러나 necrotic core의 각종 양적 수치들과 VH-TCFA와는 유의한 상관관계를 보이지 못했다. 다변량 분석결과 dense calcium의 양적 지수가 hs-CPR를 가장 잘 예측하는 인자로 분석되었다. (β=3.646, CI=2.036 to 5.255, p<0.001) 결론: 이상의 결과를 통해 혈중 hs-CRP 수치는 죽상반의 취약성보다는 동맥경화증의 양적 및 질적 정도와 연관성이 있음을 알 수 있었다. 이를 통해 혈중 hs-CRP 수치를 통해 심혈관 질환의 예후를 예상할 수 있을 것으로 생각된다.","ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES iv LIST OF TABLES vi INTRODUCTION 1 II. MATERIAL AND METHODS 2 A. PATIENTS 2 B. LABORATORY ASSESSMENT 2 C. IVUS IMAGING AND ANALYSIS 2 D. STATISTICAL ANALYSIS 3 III. RESULTS 4 A. BASELINE CLINCAL AND VH-IVUS DATA 4 B. CORRELATION BETWEENHS-CRP AND PLAQUE COMPONENTS 9 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 23","Master"]},{"key":"dc:title","label":"Title","values":["hs-CRP level represents the disease burden and the age but not vulnerability of coronary atherosclerosis","혈중 hs-CRP와 관상동맥경화증 중등도 및 죽상반 취약성과의 연관 관계에 대한 연구"]}]}],"canonical_facts":{"dc:contributor":["탁, 승제","대학원 의학과","200624544","박, 세준"],"dc:creator":["박, 세준"],"dc:date":["2013-12-19","2013"],"dc:description":["BACKGROUND: hs-CRP (high sensitive C-reactive protein) has been known as a systemic inflammatory marker of atherosclerosis and considered as one of the predictors of future cardiac events. Some reports presented hs-CRP level was associated with plaque vulnerability but most studies were performed by assessing focal target plaque but not whole plaques from a coronary tree. METHODS: To evaluate of the relationship of plasma hs-CRP level and volumetric plaque composition of the coronary arterial tree, we performed ‘whole vessel” virtual histology-intravascular ultrasound (VH-IVUS) in 189 vessels of 63 patients. The components of atherosclerosis were classified as fibrous (FI), fibrous-fatty (FF), necrotic core (NC) and dense calcium (DC). Quantitative assessment of these plaque components and the presence of VH-IVUS–derived thin-cap fibroatheroma (VH-TCFA) in the coronary arterial trees were compared to hs-CRP levels in individuals. hs-CRP levels were measured before coronary angiogram and IVUS study. RESULTS: Forty-nine patients (77.8%) were diagnosed with acute coronary syndrome in this population. The mean values of hs-CRP were 0.24±0.52 mg/dl (0~3.27mg/dl). The analyzed vessel length was 56.1±17.4 mm for the left anterior descending coronary artery, 51.9±19.0 mm for the left circumflex coronary artery, and 74.2±18.8 mm for the right coronary artery. The number of VH-TCFAs was 1.0±0.8 for the left anterior descending, 0.6±0.7 for the left circumflex, and 0.8±1.0 for the right coronary arteries.The hs-CRP levels were positively correlated to mean plaque burden, total plaque volume index, volume index of FF and DC. But parameters of NC and the number of VH-TCFA were not related with hs-CRP level. In multivariate analysis, the volume index of DC was most reliable factor to hs-CRP (β=3.646, CI=2.036 to 5.255, p<0.001) CONCLUSIONS: This three-vessel VH-IVUS presented that hs-CRP were related to the total atherosclerotic burden and the maturing (coronary calcium) but not vulnerable features (NC or VH-TCFA) of plaques in coronary arterial tree. Increased hs-CRP level as a biomarker to predict cardiovascular events might imply atherosclerosis severity of whole coronary tree but not current plaque vulnerability.","목적: hs-CRP (high sensitive C-reactive protein)는 동맥경화증의 염증 표지자로 알려져 있으며, 심혈관 질환의 예후를 예측하는 인자로도 인식되고 있다.몇몇 연구들을 통해 hs-CRP 수치가 죽상반의 취약성과 연관이 있다고 밝히고 있지만, 이들 대부분은 관상동맥 전체가 아닌 국소적인 죽상반에 대한 연구로써 그 한계점을 가지고 있다. 방법: 63명의 환자들의 총 189개의 혈관에 대해서 가장조직-혈관내초음파를 시행하여 분석한 죽상반결과를 혈중 hs-CRP 수치와 비교 분석하였다. 가상조직 혈관내초음파는죽상반의 성분을 fibrous, fibrofatty, necrotic core, dense calicum으로4개의 색을 통해 구별하였고, 죽상반의 양적 분석 결과 및 thin cap fibroatheroma(VH-TCFA)유무도 hs-CRP와 수치와 비교하였다. 혈중 hs-CRP는 혈관내 초음파 및 관상동맥 조영술 전에 채혈하였다. 결과: 급성 관동맥 증후군은 전체 환자 중49명(77.8%)이였다.혈중 hs-CRP 수치는 평균 0.24±0.52 mg/dl (0~3.27mg/dl)이였고, 혈관의 길이는 각각 좌전하행지56.1±17.4 mm,좌회선지 51.9±19.0 mm, 우관상동맥74.2±18.8 mm였다. VH-TCFAs는 평균적으로 좌전하행지 1.0±0.8개, 좌회선지 0.6 ±0.7개, 우관상동맥0.8±1.0개가 존재하였다.혈중 hs-CRP 수치는 평균 죽상반 양, 총 죽상반 양, fibrofatty 및 dense calcium의 양적 지수와 양의 상관관계를 보였다. 그러나 necrotic core의 각종 양적 수치들과 VH-TCFA와는 유의한 상관관계를 보이지 못했다. 다변량 분석결과 dense calcium의 양적 지수가 hs-CPR를 가장 잘 예측하는 인자로 분석되었다. (β=3.646, CI=2.036 to 5.255, p<0.001) 결론: 이상의 결과를 통해 혈중 hs-CRP 수치는 죽상반의 취약성보다는 동맥경화증의 양적 및 질적 정도와 연관성이 있음을 알 수 있었다. 이를 통해 혈중 hs-CRP 수치를 통해 심혈관 질환의 예후를 예상할 수 있을 것으로 생각된다.","ABSTRACT i TABLE OF CONTENTS iii LIST OF FIGURES iv LIST OF TABLES vi INTRODUCTION 1 II. MATERIAL AND METHODS 2 A. PATIENTS 2 B. LABORATORY ASSESSMENT 2 C. IVUS IMAGING AND ANALYSIS 2 D. STATISTICAL ANALYSIS 3 III. RESULTS 4 A. BASELINE CLINCAL AND VH-IVUS DATA 4 B. CORRELATION BETWEENHS-CRP AND PLAQUE COMPONENTS 9 IV. DISCUSSION 15 V. CONCLUSION 18 REFERENCES 19 국문요약 23","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/8652","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000014769","000000014769"],"dc:language":["en"],"dc:subject":["high sensitive C-reactive protein","hs-CRP","coronary atherosclerosis","virtual histology","intravascular ultrasound","vulnerable plaque","vulnerability","관상동맥경화증","혈관내 초음파","죽상반 취약성"],"dc:title":["hs-CRP level represents the disease burden and the age but not vulnerability of coronary atherosclerosis","혈중 hs-CRP와 관상동맥경화증 중등도 및 죽상반 취약성과의 연관 관계에 대한 연구"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:44Z"}