The association between testosterone and muscle mass, muscle strength, and physical function in Korean men aged 60 and older

BACKGROUND: Ageing in men is associated with decline in serum testosterone level. Previous studies have shown that low testosterone level is an important cause of sarcopenia which contributes to development of frailty in elderly men. Sarcopenia was defined by low muscle mass in prior studies. However this study is to see the association between serum testosterone level and sarcopenia according to the new sarcopenia definition which considers not only muscle mass, but also muscle strength and gait speed in Korean men aged 60 years and older. METHOD: Cross-sectional observational study of 161 participants who underwent routine check-up at Ajou University Hospital Health Promotion Center from March 1st, 2011 to September 30th, 2012. Participants were community-dwelling healthy men aged 60 years and older. Outcome measures include muscle mass using dual energy X-ray absorptiometry (DXA), muscle strength by grip strength and physical performance by gait speed. Hypogonadism was defined by serum testosterone level of less than 350ng/dL. Muscle mass was calculated with appendicular skeletal muscle (ASM) by height square or weight. RESULTS: Serum testosterone had significant relationship with muscle mass (ASM adjusted for body weight: p=0.023). However, serum testosterone had no significant relationship with muscle mass (ASM adjusted for height square: p=0.132), muscle strength (p=0.773), and gait speed (p=0.201). Subjects were divided into quartiles according to serum testosterone level, which had no significant relationship with muscle mass (ASM/ht²: p=0.224, ASM/wt: p=0.169), muscle strength (p=0.100), and gait speed (p=0.064). Hypogonadism did not show significant relationship with sarcopenia defined by ASM/ht² (p=0.463) nor by ASM/wt (p=0.115). CONCLUSION: Decreased serum testosterone has little predictive value of functional impairment represented by muscle mass adjusted by height (ASM/ht2), muscle strength, and gait speed. However, muscle mass adjusted by body weight (ASM/wt) had significant relationship with serum testosterone.

Author dc:creator

• 오, 소현

Contributors dc:contributor

• 김, 광민
• 대학원 의학과
• 201124125

• testosterone
• hypogonadism
• muscle mass
• muscle strength
• gait speed
• sarcopenia
• 테스토스테론
• 성선저하증
• 근육량
• 근력
• 보행속도
• 근감소증

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000013602
000000013602

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/8636