The Incidence of Postoperative Nausea and Vomiting after Thyroidectomy using Three Anaesthetic Techniques
type: CreativeWork
description: Introduction: The choice of anaesthetics can affect the incidence of postoperative nausea and vomiting (PONV). This study compared the incidence of PONV in female patients who underwent thyroidectomy with anaesthesia induced by sevoflurane, propofol？ remifenanil or sevoflurane？propofol？remifentanil. Methods: 177 female patients who underwent thyroidectomy were randomly allocated to three groups. Each patient was induced and maintained using one of three regimens: (i) sevoflurane (thiopental sodium 4 ？ 5 mg/kg and sevoflurane 2.0 ？ 2.5 vol% in 50% air); (ii) total intravenous anaesthesia (TIVA; propofol？remifentanil [target blood concentrations 2.5 ？ 3.5 ？g/ml and 3.5 ？ 4.5 ng/ml, respectively]); or (iii) combined inhalation and intravenous anaesthesia (sevoflurane 1.0 vol% in 50% air plus propofol？remifentanil [target blood concentrations 1.5 ？ 2.5 ？g/ml and 2.5 ？ 3.5 ng/ml, respectively]) The incidence and severity of PONV and the need for rescue antiemetics were assessed at 0 ？ 24 h postoperatively. Results: The overall incidence of PONV was significantly lower in the TIVA and combined groups compared with the sevoflurane group (33.9%, 39.0% and 64.4%, respectively). Conclusion: The maintenance of anesthesia with propofol？remifentanil or sevoflurane？propofol？remifentanil decreased the incidence of PONV compared with sevoflurane alone.
abstract: Introduction: The choice of anaesthetics can affect the incidence of postoperative nausea and vomiting (PONV). This study compared the incidence of PONV in female patients who underwent thyroidectomy with anaesthesia induced by sevoflurane, propofol？ remifenanil or sevoflurane？propofol？remifentanil. Methods: 177 female patients who underwent thyroidectomy were randomly allocated to three groups. Each patient was induced and maintained using one of three regimens: (i) sevoflurane (thiopental sodium 4 ？ 5 mg/kg and sevoflurane 2.0 ？ 2.5 vol% in 50% air); (ii) total intravenous anaesthesia (TIVA; propofol？remifentanil [target blood concentrations 2.5 ？ 3.5 ？g/ml and 3.5 ？ 4.5 ng/ml, respectively]); or (iii) combined inhalation and intravenous anaesthesia (sevoflurane 1.0 vol% in 50% air plus propofol？remifentanil [target blood concentrations 1.5 ？ 2.5 ？g/ml and 2.5 ？ 3.5 ng/ml, respectively]) The incidence and severity of PONV and the need for rescue antiemetics were assessed at 0 ？ 24 h postoperatively. Results: The overall incidence of PONV was significantly lower in the TIVA and combined groups compared with the sevoflurane group (33.9%, 39.0% and 64.4%, respectively). Conclusion: The maintenance of anesthesia with propofol？remifentanil or sevoflurane？propofol？remifentanil decreased the incidence of PONV compared with sevoflurane alone.
author: 원, 영주
language: en
date published: 2012-11-01
date modified: 2026-07-24T00:51:39Z
provider: Ajou University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Ajou University