Development of Nanoprobes for the Biological Imaging Using Positive Charged Quantum Dots and Upconversion Nanoparticles

Nanoparticles (NPs) have unique physicochemical properties due to the quantum confinement effect. Semiconductor quantum dots (QDs) or upconversion nanoparticles (UCNPs) exhibit interesting properties such as high photoluminescence, photostability, dual magnetic/optical modality. In this study, biocompatible and stable NPs were developed through the various surface modifications. NPs were functionalized by its conjugation with various molecules including antibody for detection of kappa opioid receptor, small peptide for detection of integrin ανβ3 and oligonucleotides for the detection of influenza virus. These functionalized NPs were useful to visualize the endocytosis of kappa opioid receptor in live cell, to acquire in vivo imaging of tumor expressing integrin ανβ3 in mice, and to detect sequence-specific oligonucleotides. These results show the potential of these nanoprobes to apply for the drug screening and in vivo multiplex imaging.

Author dc:creator

• 이, 정한

Contributors dc:contributor

• 박, 선
• 대학원 의생명과학과
• 200824283

• kappa opioid receptor
• integrin ανβ3
• influenza virus
• endocytosis
• tumor imaging
• durg screening
• in vivo multiplex imaging
• QD
• UCNP

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011387
000000011387

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/4348