Interactions Between Medical Prefrontal Cortex, Orbitofrontal Cortex and Motor Cortex in Value-based Decision Making

We investigated how different sub-regions of rodent prefrontal cortex contribute to value-based decision making, by comparing neural signals related to animal’s choice, its outcome, and action value in orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) of rats performing a dynamic two-armed bandit (TAB) task. And we also examined neuronal activity in the lateral (AGl) and medial (AGm) agranular cortex, corresponding to the primary and secondary motor cortex, respectively, in rats performing a dynamic dual assignment with hold (DAWH) task. Neural signals for upcoming action selection arose in the mPFC, including the anterior cingulate cortex, only immediately before the behavioral manifestation of animal’s choice, suggesting that rodent prefrontal cortex is not involved in advanced action planning. On the other hand, neural signals for an upcoming choice arose ~500 ㎳ before behavioral manifestation of the animal’s choice in the AGm, which is by far the earliest choice-related neuronal activity found in the rat brain under free-choice conditions. Both OFC and mPFC conveyed signals related to the animal’s past choices and their outcomes over multiple trials, but neural signals for chosen value and reward prediction error were more prevalent in the OFC. Meanwhile, the AGm conveyed all the signals necessary to update the value of chosen action after the choice outcome was revealed. In contrast, upcoming choice signals arose later and chosen value signals were weaker in the AGl. Consequently, our results suggest that rodent OFC and mPFC serve distinct roles in value-based decision making, and that the OFC plays a prominent role in updating the values of outcomes expected from chosen actions and a secondary motor cortex is uniquely involved in both updating and reading out value signals for flexible action selection in rats.

Author dc:creator

• 설, 정훈

Contributors dc:contributor

• 정, 민환
• 대학원 의학과
• 200524346

• 내측 전전두피질
• 안와전두피질
• 운동피질
• Prefrontal Cortex
• Orbitofrontal Cortex
• Motor Cortex

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011696
000000011696

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/4336