{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/4333"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/4333","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion","abstract":"Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation.","abstract_html":"Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation.","abstract_has_math":false,"creators":["최, 이화"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["김, 종엽","대학원 의학과","200924258"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-11-01T01:28:57Z","date_published":"2011-11-01T01:28:57Z","updated_at":"2026-07-24T00:51:34Z","subjects":["경비 기관내삽관","경구 기관내삽관","목표농도조절주입","remifentanil","propofol","nasotracheal intubation","orotracheal intubation"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257","000000011257"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257","code":true},{"text":"000000011257","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/4333","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["김, 종엽","대학원 의학과","200924258","최, 이화"]},{"key":"dc:creator","label":"Author","values":["최, 이화"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-11-01T01:28:57Z","2011"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["경비 기관내삽관","경구 기관내삽관","목표농도조절주입","remifentanil","propofol","nasotracheal intubation","orotracheal intubation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/4333","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257","000000011257"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation.","ABSTRACTⅰ TABLE OF CONTENTSⅱ LIST OF FIGURES ⅲ LIST OF TABLESⅳ TEXTⅴ Ⅰ. INTRODUCTION 1 Ⅱ. METHODS 2 Ⅲ. RESULTS 6 Ⅳ. DISCUSSION 9 V. CONCLUSION 17 REFERENCES ⅵ 국문요약 ⅶ","Master"]},{"key":"dc:title","label":"Title","values":["Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion","Propofol 목표농도조절주입 중 경비 또는 경구 기관내 삽관을 위한 remifentanil의 효과처농도 비교"]}]}],"canonical_facts":{"dc:contributor":["김, 종엽","대학원 의학과","200924258","최, 이화"],"dc:creator":["최, 이화"],"dc:date":["2011-11-01T01:28:57Z","2011"],"dc:description":["Background: The purpose of this study was to determine the effect-site concentrations of remifentanil required for acceptable nasotracheal (NT) intubation in adults after propofol target-controlled infusion (TCI) without neuromuscular blocking agent, and whether or not these concentrations differ from those for orotracheal (OT) intubation. Methods: Fifty patients were assigned to receive either OT intubation (OT group, n = 25) or NT intubation (NT group, n = 25). Anaesthesia was induced with propofol TCI at the effect-site concentration of 5.0 μg/ml. Two minutes later, the predetermined effect-site concentration of remifentanil was started (from 4.5 ng/ml) using Dixon’s up-and-down method. Tracheal intubation was performed during the remifentanil infusion 2 min after beginning. Acceptable intubation was defined as excellent or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and NT groups was 5.00 (3.34-7.46) ng/ml and 5.75 (3.66-7.84) ng/mlv, respectively (P = 0.592). Conclusion: The effect-site concentration of remifentanil for acceptable NT intubation was 6.08 ng/ml in 50% of adults during propofol TCI at an effect-site concentration of 5.0 μg/ml without neuromuscular blocking agent. The predicted effect-site concentration of remifentanil for NT intubation was not different from OT intubation.","ABSTRACTⅰ TABLE OF CONTENTSⅱ LIST OF FIGURES ⅲ LIST OF TABLESⅳ TEXTⅴ Ⅰ. INTRODUCTION 1 Ⅱ. METHODS 2 Ⅲ. RESULTS 6 Ⅳ. DISCUSSION 9 V. CONCLUSION 17 REFERENCES ⅵ 국문요약 ⅶ","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/4333","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011257","000000011257"],"dc:language":["en"],"dc:subject":["경비 기관내삽관","경구 기관내삽관","목표농도조절주입","remifentanil","propofol","nasotracheal intubation","orotracheal intubation"],"dc:title":["Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion","Propofol 목표농도조절주입 중 경비 또는 경구 기관내 삽관을 위한 remifentanil의 효과처농도 비교"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:34Z"}