Effectiveness of autogenous tooth bone used as a graft material for regeneration of bone in minipig

PURPOSE: The aim of this study was to evaluate the effect of autogenous tooth bone used as a graft material for regeneration of bone in artificial bony defect of the minipigs. MATERIAL AND METHODS: Five healthy minipigs, weighing about 35-40 ㎏, were used in this study. Four standardized artificial two-walled bony defect, 5㎜ sized in length and depth were made on bilateral parial edentulous alveolar ridge on mandible of minipig, and autogenous tooh bone was augmented in right side as a experimental group. On the other hand only alloplastic bone graft material HA was grafted with same size and same manner in left side as a control group. All minipigs were sacrificed at 4 weeks after bone graft and histologically evaluated under light microscope with Haematoxylin-eosin staining. Specimens were also semi-quantitatively evaluated via histomorphometric study. Percentage of new bone over total area was evaluated using digital software for area calculation. RESULT: All specimens were available but one in the left side (control group) and two in the right side (experimental group) were missing during specimen preparation. As a result of this experiment, bone formation and remodeling process were examined in all experimental group and the control, with more regenerative capacity in the experimental group. Mean percentage area for new bone were 43.74±11.96 % and 30.79±2.93 % for experimental and control groups, respectively. CONCLUSION: We hereby report that autogenous tooth bone is a good alternative to autogenous bone with expectation of possible clinical feasibility of autogenous tooth bone graft in reconstruction of bony defect.

Author dc:creator

• 정, 혜린

Contributors dc:contributor

• 이, 정근
• 대학원 의학과
• 200824551

• autogenous tooth bone
• minipig
• bony defect
• histomorphometric study
• 미니피그
• 자가치아뼈
• 골형성

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000011217
000000011217

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/4323