{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/2254"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/2254","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할","abstract":"\"ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in primary cultures of spleen tissues C. CD4+T cells from normal, BDN, and BD-like splenocytes were co-cultured with normal dendritic cells from normal mice D. Adoptive transfer with CD4+CD25+T cells up-regulated the frequencies of T cell in BD-like mice E. Change of symptoms in BD-like mice after adoptive transfer F. The change of severity score in transferred with CD4+CD25+T cells to BD-like mice G. CD4+CD25+T cells transfer up-regulated serum IL-10 and TGF-β levels and down-regulated IFN-γ and TNF-α levels H. Serum IL-6 and IL-17 levels were down-regulated after transfer I. The differences of serum cytokine amounts between the average of not transferred BD-like mice and 3x10^5 CD4+CD25+T cells transferred each BD-like mouse Ⅳ. DISCUSSION Ⅴ. CONCLUSION REFERENCES 국문요약 \"","abstract_html":""ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in primary cultures of spleen tissues C. CD4+T cells from normal, BDN, and BD-like splenocytes were co-cultured with normal dendritic cells from normal mice D. Adoptive transfer with CD4+CD25+T cells up-regulated the frequencies of T cell in BD-like mice E. Change of symptoms in BD-like mice after adoptive transfer F. The change of severity score in transferred with CD4+CD25+T cells to BD-like mice G. CD4+CD25+T cells transfer up-regulated serum IL-10 and TGF-β levels and down-regulated IFN-γ and TNF-α levels H. Serum IL-6 and IL-17 levels were down-regulated after transfer I. The differences of serum cytokine amounts between the average of not transferred BD-like mice and 3x10^5 CD4+CD25+T cells transferred each BD-like mouse Ⅳ. DISCUSSION Ⅴ. CONCLUSION REFERENCES 국문요약 "","abstract_has_math":false,"creators":["심, 주아"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["손, 성향","대학원 의생명과학과","200724296"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-04-13T05:07:06Z","date_published":"2011-04-13T05:07:06Z","updated_at":"2026-07-24T00:51:31Z","subjects":["베체트병"],"languages":["ko"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672","000000009672"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672","code":true},{"text":"000000009672","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/2254","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["손, 성향","대학원 의생명과학과","200724296","심, 주아"]},{"key":"dc:creator","label":"Author","values":["심, 주아"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-04-13T05:07:06Z","2009"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["베체트병"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ko"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/2254","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672","000000009672"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in primary cultures of spleen tissues C. CD4+T cells from normal, BDN, and BD-like splenocytes were co-cultured with normal dendritic cells from normal mice D. Adoptive transfer with CD4+CD25+T cells up-regulated the frequencies of T cell in BD-like mice E. Change of symptoms in BD-like mice after adoptive transfer F. The change of severity score in transferred with CD4+CD25+T cells to BD-like mice G. CD4+CD25+T cells transfer up-regulated serum IL-10 and TGF-β levels and down-regulated IFN-γ and TNF-α levels H. Serum IL-6 and IL-17 levels were down-regulated after transfer I. The differences of serum cytokine amounts between the average of not transferred BD-like mice and 3x10^5 CD4+CD25+T cells transferred each BD-like mouse Ⅳ. DISCUSSION Ⅴ. CONCLUSION REFERENCES 국문요약 \"","Master"]},{"key":"dc:title","label":"Title","values":["단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할"]}]}],"canonical_facts":{"dc:contributor":["손, 성향","대학원 의생명과학과","200724296","심, 주아"],"dc:creator":["심, 주아"],"dc:date":["2011-04-13T05:07:06Z","2009"],"dc:description":["\"ABSTRACT TABLE OF CONTENTS LIST OF FIGURE LIST OF TABLES Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS A. Antibodies and reagents B. Animal experiments C. BD-like symptoms D. Flow cytometry E. Splenocyte culture and generation of Treg cells F. Dendritic cells isolation and culture G. Co-culture of CD4+T cells with DCs H. Isolation of CD4+CD25+T cells I.Adoptive transfer of CD4+CD25+T and CD4+CD25-T cells to BD-like mice J. ELISA K. Reverse transcription PCR (RT-PCR) L. Statistical analysis Ⅲ. RESULTS A. CD4+CD25+ Treg cells in BD-like mice compared to BDN mice B. CD4+CD25+T cells were amplified in primary cultures of spleen tissues C. CD4+T cells from normal, BDN, and BD-like splenocytes were co-cultured with normal dendritic cells from normal mice D. Adoptive transfer with CD4+CD25+T cells up-regulated the frequencies of T cell in BD-like mice E. Change of symptoms in BD-like mice after adoptive transfer F. The change of severity score in transferred with CD4+CD25+T cells to BD-like mice G. CD4+CD25+T cells transfer up-regulated serum IL-10 and TGF-β levels and down-regulated IFN-γ and TNF-α levels H. Serum IL-6 and IL-17 levels were down-regulated after transfer I. The differences of serum cytokine amounts between the average of not transferred BD-like mice and 3x10^5 CD4+CD25+T cells transferred each BD-like mouse Ⅳ. DISCUSSION Ⅴ. CONCLUSION REFERENCES 국문요약 \"","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/2254","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000009672","000000009672"],"dc:language":["ko"],"dc:subject":["베체트병"],"dc:title":["단순포진바이러스로 유도된 베체트병 마우스모델에서 CD4+CD25+ 조절 T 세포의 역할"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:31Z"}