뇌종양 동물모델에서의 인간신경줄기세포주의 종양으로의 특이적 이주에 관한 입체적 분석
"TABLE OF CONTENTS ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅴ ABBREVIATION ⅶ Ⅰ. INTRODUCTION 1 Ⅱ. MATERIALS AND METHODS 3 1. Cell culture 3 2. In vivo protocol of experimental tumor models 3 3. In vitro and in vivo cell proliferation assays 4 4. In vivo analysis of tumor-tropism of human neural stem cells 5 5. X-gal stain 6 6. Cell count and unbiased stereology in a tumor region of rats 7 7 .Cell count and unbiased stereology in a entire brain of rats 8 8. Labeling of F3 Cells with 5-bromo-2-deoxyuridine 8 9. Hematoxylin and Eosin stain 9 10. Beta-galactosidase immunofluoresecence 9 11. Statistical Analysis 10 Ⅲ. RESULTS 11 1. Tumor-tropism pattern of NSCs 11 2. Migration rate of NSCs 19 3. NSC migration studied by stereology 23 4. Histological analysis 28 5. Proliferation of NSCs in vitro & in vivo 32 Ⅳ. DISCUSSION 37 Ⅴ. CONCLUSION 43 RFERENCES 45 국문요약 58 "
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