{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/1628"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/1628","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"Umbilical artery Doppler velocimetry in predicting the perinatal outcomes in small for gestational age infants","abstract":"OBJECTIVE: The aim of this study is to evaluate the effectiveness of the umbilical artery Doppler velocimetry in predicting perinatal outcome of small for gestational age (SGA) infants. MATERIALS AND METHODS: During from Sep. 1995 to Feb. 2006, we retrospectively studied 422 singleton pregnancies with a diagnosis of SGA at delivery, who had no chromosomal abnormalities or major structural anomalies in antenatal ultrasound, in Ajou University hospital. From this population, three subgroups were formed: normal umbilical artery systolic/ diastolic ratio (UASD); UASD ≥ 3.0 ; absent or reverse end-diastolic flow (A/REDF). The maternal characteristics and perinatal outcomes were compared between each groups. RESULTS: No differences in maternal age and parity were observed. In each groups, the mean gestational age at delivery were 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8 weeks (p<0.001), and the mean neonatal birth weight were 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm (p<0.001). The incidences of oligohydramnios were 12.4%, 17.7%, 33.3% (p=0.005), and the cesarean section rate for fetal distress were 13.7%, 23.9%, 50.0% (p=0.002). A statistically significant difference in the incidences of admission to NICU was found between the groups (41.0%, 81.2%, 100%; p<0.001). The rate of Apgar score at 5 min< 7 were 4.5%, 8.3%, 38.8% (p<0.001), and the interval from last Doppler to delivery were 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2 days (p=0.002). The incidences of averse neonatal outcome were 5.1%, 13.5%, 61.1% (p<0.001), when the definition of adverse neonatal outcomes was one or more of the followings: periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH, > grade 2), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS) and perinatal death. The logistic regression showed UASD a statistically significant risk factor in predicting the adverse neonatal outcomes (Odds ratio 2.4; 95% CI 1.2-5.6). CONCLUSIONS: SGA infants with normal UA Doppler flow showed better perinatal outcome than those with abnormal flow. Therefore, we suggest that SGA fetus with normal UA S/D may be had a different antenatal counselling, surveillence tests, and the time of delivery compared with those with abnormal flow.","abstract_html":"OBJECTIVE: The aim of this study is to evaluate the effectiveness of the umbilical artery Doppler velocimetry in predicting perinatal outcome of small for gestational age (SGA) infants. MATERIALS AND METHODS: During from Sep. 1995 to Feb. 2006, we retrospectively studied 422 singleton pregnancies with a diagnosis of SGA at delivery, who had no chromosomal abnormalities or major structural anomalies in antenatal ultrasound, in Ajou University hospital. From this population, three subgroups were formed: normal umbilical artery systolic/ diastolic ratio (UASD); UASD ≥ 3.0 ; absent or reverse end-diastolic flow (A/REDF). The maternal characteristics and perinatal outcomes were compared between each groups. RESULTS: No differences in maternal age and parity were observed. In each groups, the mean gestational age at delivery were 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8 weeks (p&lt;0.001), and the mean neonatal birth weight were 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm (p&lt;0.001). The incidences of oligohydramnios were 12.4%, 17.7%, 33.3% (p=0.005), and the cesarean section rate for fetal distress were 13.7%, 23.9%, 50.0% (p=0.002). A statistically significant difference in the incidences of admission to NICU was found between the groups (41.0%, 81.2%, 100%; p&lt;0.001). The rate of Apgar score at 5 min&lt; 7 were 4.5%, 8.3%, 38.8% (p&lt;0.001), and the interval from last Doppler to delivery were 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2 days (p=0.002). The incidences of averse neonatal outcome were 5.1%, 13.5%, 61.1% (p&lt;0.001), when the definition of adverse neonatal outcomes was one or more of the followings: periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH, &gt; grade 2), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS) and perinatal death. The logistic regression showed UASD a statistically significant risk factor in predicting the adverse neonatal outcomes (Odds ratio 2.4; 95% CI 1.2-5.6). CONCLUSIONS: SGA infants with normal UA Doppler flow showed better perinatal outcome than those with abnormal flow. Therefore, we suggest that SGA fetus with normal UA S/D may be had a different antenatal counselling, surveillence tests, and the time of delivery compared with those with abnormal flow.","abstract_has_math":false,"creators":["문, 세희"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["김, 행수","대학원 의학과","200424178"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-03-10T01:03:14Z","date_published":"2011-03-10T01:03:14Z","updated_at":"2026-07-24T00:51:24Z","subjects":["자궁내 태아발육제한","제대동맥 도플러 파형","주산기 예후","혈류속도","단태임신"],"languages":["ko"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001921","000000001921"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001921","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001921","code":true},{"text":"000000001921","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/1628","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["김, 행수","대학원 의학과","200424178","문, 세희"]},{"key":"dc:creator","label":"Author","values":["문, 세희"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-03-10T01:03:14Z","2007"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["자궁내 태아발육제한","제대동맥 도플러 파형","주산기 예후","혈류속도","단태임신"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ko"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/1628","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001921","000000001921"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["OBJECTIVE: The aim of this study is to evaluate the effectiveness of the umbilical artery Doppler velocimetry in predicting perinatal outcome of small for gestational age (SGA) infants. MATERIALS AND METHODS: During from Sep. 1995 to Feb. 2006, we retrospectively studied 422 singleton pregnancies with a diagnosis of SGA at delivery, who had no chromosomal abnormalities or major structural anomalies in antenatal ultrasound, in Ajou University hospital. From this population, three subgroups were formed: normal umbilical artery systolic/ diastolic ratio (UASD); UASD ≥ 3.0 ; absent or reverse end-diastolic flow (A/REDF). The maternal characteristics and perinatal outcomes were compared between each groups. RESULTS: No differences in maternal age and parity were observed. In each groups, the mean gestational age at delivery were 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8 weeks (p<0.001), and the mean neonatal birth weight were 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm (p<0.001). The incidences of oligohydramnios were 12.4%, 17.7%, 33.3% (p=0.005), and the cesarean section rate for fetal distress were 13.7%, 23.9%, 50.0% (p=0.002). A statistically significant difference in the incidences of admission to NICU was found between the groups (41.0%, 81.2%, 100%; p<0.001). The rate of Apgar score at 5 min< 7 were 4.5%, 8.3%, 38.8% (p<0.001), and the interval from last Doppler to delivery were 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2 days (p=0.002). The incidences of averse neonatal outcome were 5.1%, 13.5%, 61.1% (p<0.001), when the definition of adverse neonatal outcomes was one or more of the followings: periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH, > grade 2), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS) and perinatal death. The logistic regression showed UASD a statistically significant risk factor in predicting the adverse neonatal outcomes (Odds ratio 2.4; 95% CI 1.2-5.6). CONCLUSIONS: SGA infants with normal UA Doppler flow showed better perinatal outcome than those with abnormal flow. Therefore, we suggest that SGA fetus with normal UA S/D may be had a different antenatal counselling, surveillence tests, and the time of delivery compared with those with abnormal flow.","목적: 자궁내 태아발육제한 임신에서 제대동맥 도플러혈류속도 파형에 따른 주산기 예후를 분석하고자 한다. 연구대상 및 방법: 1995년 9월부터 2006년 2월까지 아주대학교 병원에서 분만된 단태임신 신생아 중 자궁내 태아발육제한아를 분만한 산모를 대상으로 후향적 연구를 시행하였다. 산전에 제대동맥 도플러검사가 이루어지지 않았던 산모와 산전 초음파검사 및 염색체 검사에서 기형이 진단되었던 경우를 제외한 총 422명이 대상이 되었다. 제대동맥 도플러혈류속도 파형은 최고 수축기 혈류속도 (S)와 최저 이완기말 혈류속도 (D)의 비 (S/D)로 하여, 정상군 (1군)은 분만 전 마지막 측정한 제대동맥 S/D치가 3.0 미만인 경우, 비정상군은 S/D치가 3.0 이상인 군 (2군)과 최저 이완기말 파형이 소실되거나 역전된 군 (3군)으로 구분하였고, 각 군에서 모체 및 신생아의 주산기 예후를 비교하였다. 결과: 각 군에서 산모의 나이나 산과력은 차이가 없었다. 각 군에서 분만 시 재태 연령은 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8주로 3 군이 가장 낮았고, 출생 시 신생아 체중은 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm 이었다 (p<0.001). 양수과소증의 빈도는 12.4%, 17.7%, 33.3% (p=0.005), 태아곤란증에 의한 응급제왕절개분만의 빈도는 13.7%, 23.9%, 50.0%로 유의한 차이를 보였다 (p=0.002). 신생아 중환자실 입원 빈도는 41.0%, 81.2%, 100%로 유의한 차이를 보였고 (p<0.001), 7점 미만의 낮은 5분 Apgar치의 빈도는 4.5%, 8.3%, 38.8% 이었다 (p<0.001). 마지막으로 도플러 파형을 측정한 날로부터 분만까지의 기간은 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2로 3군에서 유의하게 짧았다 (p=0.002). 뇌실주위 백질 연화증, 뇌실내 출혈, 괴사성 장염, 기관지 폐이형성증, 호흡곤란 증후군, 주산기 사망 중의 어느 하나라도 있는 경우를 불량한 신생아 예후로 정의한 경우 이의 빈도는 5.1%, 13.5%, 61.1%로 유의한 차이를 보였다 (p<0.001). 불량한 신생아 예후 예측에 대한 제대동맥 도플러 S/D치는 제태연령을 보정한 후 odds ratio 2.4로 (95% 신뢰구간 1.2-5.6) 통계적으로 유의한 위험인자임을 알 수 있었다. 결론: 자궁내 태아발육제한 신생아에서 제대동맥 도플러 S/D치가 정상인 경우는 S/D치가 비정상인 군에 비해 양호한 신생아 예후를 보였다. 따라서 이들 군에 대한 산전 상담, 평가 및 분만 시기 등의 결정은 S/D치가 비정상인군과는 다르게 이루어져야 할 것이다.","\"Ⅰ. 서론 = 1 Ⅱ. 연구대상 및 방법 = 3 A. 연구대상 = 3 B. 연구방법 = 3 Ⅲ. 결과 = 5 Ⅳ. 고찰 = 8 Ⅴ. 결론 = 11 참고문헌 = 13 ABSTRACT = 17\"","Master"]},{"key":"dc:title","label":"Title","values":["Umbilical artery Doppler velocimetry in predicting the perinatal outcomes in small for gestational age infants","자궁내 태아발육제한 임신에서 제대동맥 도플러 혈류속도 파형 변화가 주산기 예후에 미치는 영향"]}]}],"canonical_facts":{"dc:contributor":["김, 행수","대학원 의학과","200424178","문, 세희"],"dc:creator":["문, 세희"],"dc:date":["2011-03-10T01:03:14Z","2007"],"dc:description":["OBJECTIVE: The aim of this study is to evaluate the effectiveness of the umbilical artery Doppler velocimetry in predicting perinatal outcome of small for gestational age (SGA) infants. MATERIALS AND METHODS: During from Sep. 1995 to Feb. 2006, we retrospectively studied 422 singleton pregnancies with a diagnosis of SGA at delivery, who had no chromosomal abnormalities or major structural anomalies in antenatal ultrasound, in Ajou University hospital. From this population, three subgroups were formed: normal umbilical artery systolic/ diastolic ratio (UASD); UASD ≥ 3.0 ; absent or reverse end-diastolic flow (A/REDF). The maternal characteristics and perinatal outcomes were compared between each groups. RESULTS: No differences in maternal age and parity were observed. In each groups, the mean gestational age at delivery were 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8 weeks (p<0.001), and the mean neonatal birth weight were 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm (p<0.001). The incidences of oligohydramnios were 12.4%, 17.7%, 33.3% (p=0.005), and the cesarean section rate for fetal distress were 13.7%, 23.9%, 50.0% (p=0.002). A statistically significant difference in the incidences of admission to NICU was found between the groups (41.0%, 81.2%, 100%; p<0.001). The rate of Apgar score at 5 min< 7 were 4.5%, 8.3%, 38.8% (p<0.001), and the interval from last Doppler to delivery were 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2 days (p=0.002). The incidences of averse neonatal outcome were 5.1%, 13.5%, 61.1% (p<0.001), when the definition of adverse neonatal outcomes was one or more of the followings: periventricular leukomalacia (PVL), intraventricular hemorrhage (IVH, > grade 2), necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), respiratory distress syndrome (RDS) and perinatal death. The logistic regression showed UASD a statistically significant risk factor in predicting the adverse neonatal outcomes (Odds ratio 2.4; 95% CI 1.2-5.6). CONCLUSIONS: SGA infants with normal UA Doppler flow showed better perinatal outcome than those with abnormal flow. Therefore, we suggest that SGA fetus with normal UA S/D may be had a different antenatal counselling, surveillence tests, and the time of delivery compared with those with abnormal flow.","목적: 자궁내 태아발육제한 임신에서 제대동맥 도플러혈류속도 파형에 따른 주산기 예후를 분석하고자 한다. 연구대상 및 방법: 1995년 9월부터 2006년 2월까지 아주대학교 병원에서 분만된 단태임신 신생아 중 자궁내 태아발육제한아를 분만한 산모를 대상으로 후향적 연구를 시행하였다. 산전에 제대동맥 도플러검사가 이루어지지 않았던 산모와 산전 초음파검사 및 염색체 검사에서 기형이 진단되었던 경우를 제외한 총 422명이 대상이 되었다. 제대동맥 도플러혈류속도 파형은 최고 수축기 혈류속도 (S)와 최저 이완기말 혈류속도 (D)의 비 (S/D)로 하여, 정상군 (1군)은 분만 전 마지막 측정한 제대동맥 S/D치가 3.0 미만인 경우, 비정상군은 S/D치가 3.0 이상인 군 (2군)과 최저 이완기말 파형이 소실되거나 역전된 군 (3군)으로 구분하였고, 각 군에서 모체 및 신생아의 주산기 예후를 비교하였다. 결과: 각 군에서 산모의 나이나 산과력은 차이가 없었다. 각 군에서 분만 시 재태 연령은 37.3 ± 2.8, 36.0 ± 2.3, 32.4 ± 2.8주로 3 군이 가장 낮았고, 출생 시 신생아 체중은 2311.6 ± 371.3, 1963.1 ± 402.7, 1168.9 ± 413.6 gm 이었다 (p<0.001). 양수과소증의 빈도는 12.4%, 17.7%, 33.3% (p=0.005), 태아곤란증에 의한 응급제왕절개분만의 빈도는 13.7%, 23.9%, 50.0%로 유의한 차이를 보였다 (p=0.002). 신생아 중환자실 입원 빈도는 41.0%, 81.2%, 100%로 유의한 차이를 보였고 (p<0.001), 7점 미만의 낮은 5분 Apgar치의 빈도는 4.5%, 8.3%, 38.8% 이었다 (p<0.001). 마지막으로 도플러 파형을 측정한 날로부터 분만까지의 기간은 7.1 ± 8.1, 4.8 ± 4.8, 3.8 ± 3.2로 3군에서 유의하게 짧았다 (p=0.002). 뇌실주위 백질 연화증, 뇌실내 출혈, 괴사성 장염, 기관지 폐이형성증, 호흡곤란 증후군, 주산기 사망 중의 어느 하나라도 있는 경우를 불량한 신생아 예후로 정의한 경우 이의 빈도는 5.1%, 13.5%, 61.1%로 유의한 차이를 보였다 (p<0.001). 불량한 신생아 예후 예측에 대한 제대동맥 도플러 S/D치는 제태연령을 보정한 후 odds ratio 2.4로 (95% 신뢰구간 1.2-5.6) 통계적으로 유의한 위험인자임을 알 수 있었다. 결론: 자궁내 태아발육제한 신생아에서 제대동맥 도플러 S/D치가 정상인 경우는 S/D치가 비정상인 군에 비해 양호한 신생아 예후를 보였다. 따라서 이들 군에 대한 산전 상담, 평가 및 분만 시기 등의 결정은 S/D치가 비정상인군과는 다르게 이루어져야 할 것이다.","\"Ⅰ. 서론 = 1 Ⅱ. 연구대상 및 방법 = 3 A. 연구대상 = 3 B. 연구방법 = 3 Ⅲ. 결과 = 5 Ⅳ. 고찰 = 8 Ⅴ. 결론 = 11 참고문헌 = 13 ABSTRACT = 17\"","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/1628","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000001921","000000001921"],"dc:language":["ko"],"dc:subject":["자궁내 태아발육제한","제대동맥 도플러 파형","주산기 예후","혈류속도","단태임신"],"dc:title":["Umbilical artery Doppler velocimetry in predicting the perinatal outcomes in small for gestational age infants","자궁내 태아발육제한 임신에서 제대동맥 도플러 혈류속도 파형 변화가 주산기 예후에 미치는 영향"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:24Z"}