{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/1473"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/1473","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma","abstract":"BACKGROUND: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection may result from host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: Between March 2002 and December 2004, 730 Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the genotype distributions of the HBV clearance and persistence groups were compared to investigate the association between HBV persistence and SNPs of IL-12A. And the genotype distributions of the HCC and no HCC groups were compared to investigate the association between development of HCC and SNPs of IL-12A. RESULTS: We asssesed SNPs in IL-12A at position +6400, +6624 and +7003. In IL-12A exon 7 +6400, the most common genotype was C/C and T/T genotype was not found. In IL-12A exon 7 +6624, the most common genotype was G/G. And in IL-12A 3' UTR +7003, the most common genotype was T/T. Study subjects were classified into 2 groups, the HBV persistence and the HBV clearance. On the basis of logistic regression analysis, no statistically significant association with HBV persistence was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. Also, no statistically significant association with HCC development was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. CONCLUSION: This study suggest that SNPs and haplotype of IL-12A were not associated with HBV persistence and development of HCC. Further studies are needed to identify the host genetic factors including SNPs.","abstract_html":"BACKGROUND: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection may result from host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: Between March 2002 and December 2004, 730 Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the genotype distributions of the HBV clearance and persistence groups were compared to investigate the association between HBV persistence and SNPs of IL-12A. And the genotype distributions of the HCC and no HCC groups were compared to investigate the association between development of HCC and SNPs of IL-12A. RESULTS: We asssesed SNPs in IL-12A at position +6400, +6624 and +7003. In IL-12A exon 7 +6400, the most common genotype was C/C and T/T genotype was not found. In IL-12A exon 7 +6624, the most common genotype was G/G. And in IL-12A 3' UTR +7003, the most common genotype was T/T. Study subjects were classified into 2 groups, the HBV persistence and the HBV clearance. On the basis of logistic regression analysis, no statistically significant association with HBV persistence was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. Also, no statistically significant association with HCC development was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. CONCLUSION: This study suggest that SNPs and haplotype of IL-12A were not associated with HBV persistence and development of HCC. Further studies are needed to identify the host genetic factors including SNPs.","abstract_has_math":false,"creators":["박, 진선"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["조, 성원","대학원 의학과","104875"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-02-18T04:58:49Z","date_published":"2011-02-18T04:58:49Z","updated_at":"2026-07-24T00:51:22Z","subjects":["B형 간염","Interleukin-12","Single nucleotide polymorphism","B viral hepatits","간세포암"],"languages":["ko"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002689","000000002689"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002689","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002689","code":true},{"text":"000000002689","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/1473","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["조, 성원","대학원 의학과","104875","박, 진선"]},{"key":"dc:creator","label":"Author","values":["박, 진선"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-02-18T04:58:49Z","2007"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["B형 간염","Interleukin-12","Single nucleotide polymorphism","B viral hepatits","간세포암"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ko"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/1473","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002689","000000002689"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["BACKGROUND: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection may result from host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: Between March 2002 and December 2004, 730 Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the genotype distributions of the HBV clearance and persistence groups were compared to investigate the association between HBV persistence and SNPs of IL-12A. And the genotype distributions of the HCC and no HCC groups were compared to investigate the association between development of HCC and SNPs of IL-12A. RESULTS: We asssesed SNPs in IL-12A at position +6400, +6624 and +7003. In IL-12A exon 7 +6400, the most common genotype was C/C and T/T genotype was not found. In IL-12A exon 7 +6624, the most common genotype was G/G. And in IL-12A 3' UTR +7003, the most common genotype was T/T. Study subjects were classified into 2 groups, the HBV persistence and the HBV clearance. On the basis of logistic regression analysis, no statistically significant association with HBV persistence was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. Also, no statistically significant association with HCC development was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. CONCLUSION: This study suggest that SNPs and haplotype of IL-12A were not associated with HBV persistence and development of HCC. Further studies are needed to identify the host genetic factors including SNPs.","배경: B형 간염 바이러스 (hepatitis B virus; HBV) 감염은 다양한 임상 경과를 갖는다. HBV 감염의 자연경과의 다양성의 원인으로 유전자 다형성을 포함한 숙주 요인을 들 수 있으며, 사이토카인은 숙주 면역능에 중요한 역할을 한다. 본 연구는 HBV 감염 후의 자연 경과 및 간세포암 발생과 interleukin(IL)-12A 유전자 다형성(single neucleotide polymorphisms, SNP)과의 상관성에 대해 알아보고자 하였다. 대상 및 방법: 2002년 3월부터 2004년 12월까지 아주대병원 소화기 내과 외래를 내원한 HBV 만성화군 730명과 HBV 감염 후 자연 회복된 HBV 제거군 320명을 포함하여 총 1,050명을 대상으로 하였다. B형 간염의 만성화와 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군과 HBV 제거군의 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였고, 간세포암 발생과 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군을 간세포암군과 비간세포암군으로 나누어 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였다. 결과: IL-12A의 SNP는, IL-12A 유전자 번역 시작 부위로부터 +6400, +6624, +7003 부위에서 조사하였고, IL-12A exon 7 +6400 부위는 C/C 유전자형이 가장 흔하였고, T/T 유전자형은 발견되지 않았다. IL-12A exon 7 +6624 부위는 G/G 유전자형이 가장 흔하였고, IL-12A 3’UTR +7003 부위는 T/T 유전자형이 가장 흔하게 발견되었다. 대상 환자를 HBV 만성화군과 HBV 제거군으로 분류하고, IL-12A SNP와 HBV 만성화와의 관련성을 조사한 결과 IL-12A exon 7 +6400 및 +6624 두 부위 및 3' UTR +7003 한 부위의 SNP는 HBV 만성화군과 HBV 제거군 간에 통계적으로 유의한 차이를 보이지 않았다. 또한 +6400/+6624/+7003 haplotype에 따른 HBV 만성화 관련성 조사에서도 양군 간에 통계적으로 유의한 차이점은 관찰되지 않았다. IL-12A SNP와 간세포암과의 관련성을 조사한 결과 각각의 SNP 및 +6400/+6624/+7003 haplotype에 따른 HBV 감염 후 간세포암 발생과의 연관성도 관찰되지 않았다. 결론: IL-12A SNP 및 haplotype은 HBV 간염 진행 및 간세포암 발생과 연관성을 보이지 않았다. HBV 감염의 자연 경과에서 숙주의 유전적 인자의 중요성을 상기해 볼때 향후 환자의 유전적 소인에 대한 연구가 더 진행되어야 할 것으로 판단된다.","\"Ⅰ. 서론 = 1 Ⅱ. 연구대상 및 방법 = 3 A. 연구대상 = 3 B. 방법 = 4 1. 유전자형 분석 (Genotyping) = 4 C. 통계분석 = 4 Ⅲ. 결과 = 6 Ⅳ. 고찰 = 11 Ⅴ. 결론 = 14 참고문헌 = 15 ABSTRACT = 18\"","Master"]},{"key":"dc:title","label":"Title","values":["Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma","B형 간염의 만성화 및 간세포암 발생과 Interleukin-12 유전자 다형성"]}]}],"canonical_facts":{"dc:contributor":["조, 성원","대학원 의학과","104875","박, 진선"],"dc:creator":["박, 진선"],"dc:date":["2011-02-18T04:58:49Z","2007"],"dc:description":["BACKGROUND: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection may result from host immune factors including single nucleotide polymorphisms(SNPs), and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma(HCC) and SNPs of interleukin(IL)-12A. METHODS: Between March 2002 and December 2004, 730 Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the genotype distributions of the HBV clearance and persistence groups were compared to investigate the association between HBV persistence and SNPs of IL-12A. And the genotype distributions of the HCC and no HCC groups were compared to investigate the association between development of HCC and SNPs of IL-12A. RESULTS: We asssesed SNPs in IL-12A at position +6400, +6624 and +7003. In IL-12A exon 7 +6400, the most common genotype was C/C and T/T genotype was not found. In IL-12A exon 7 +6624, the most common genotype was G/G. And in IL-12A 3' UTR +7003, the most common genotype was T/T. Study subjects were classified into 2 groups, the HBV persistence and the HBV clearance. On the basis of logistic regression analysis, no statistically significant association with HBV persistence was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. Also, no statistically significant association with HCC development was observed with IL-12A exon 7 +6400, +6624, 3' UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. CONCLUSION: This study suggest that SNPs and haplotype of IL-12A were not associated with HBV persistence and development of HCC. Further studies are needed to identify the host genetic factors including SNPs.","배경: B형 간염 바이러스 (hepatitis B virus; HBV) 감염은 다양한 임상 경과를 갖는다. HBV 감염의 자연경과의 다양성의 원인으로 유전자 다형성을 포함한 숙주 요인을 들 수 있으며, 사이토카인은 숙주 면역능에 중요한 역할을 한다. 본 연구는 HBV 감염 후의 자연 경과 및 간세포암 발생과 interleukin(IL)-12A 유전자 다형성(single neucleotide polymorphisms, SNP)과의 상관성에 대해 알아보고자 하였다. 대상 및 방법: 2002년 3월부터 2004년 12월까지 아주대병원 소화기 내과 외래를 내원한 HBV 만성화군 730명과 HBV 감염 후 자연 회복된 HBV 제거군 320명을 포함하여 총 1,050명을 대상으로 하였다. B형 간염의 만성화와 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군과 HBV 제거군의 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였고, 간세포암 발생과 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군을 간세포암군과 비간세포암군으로 나누어 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였다. 결과: IL-12A의 SNP는, IL-12A 유전자 번역 시작 부위로부터 +6400, +6624, +7003 부위에서 조사하였고, IL-12A exon 7 +6400 부위는 C/C 유전자형이 가장 흔하였고, T/T 유전자형은 발견되지 않았다. IL-12A exon 7 +6624 부위는 G/G 유전자형이 가장 흔하였고, IL-12A 3’UTR +7003 부위는 T/T 유전자형이 가장 흔하게 발견되었다. 대상 환자를 HBV 만성화군과 HBV 제거군으로 분류하고, IL-12A SNP와 HBV 만성화와의 관련성을 조사한 결과 IL-12A exon 7 +6400 및 +6624 두 부위 및 3' UTR +7003 한 부위의 SNP는 HBV 만성화군과 HBV 제거군 간에 통계적으로 유의한 차이를 보이지 않았다. 또한 +6400/+6624/+7003 haplotype에 따른 HBV 만성화 관련성 조사에서도 양군 간에 통계적으로 유의한 차이점은 관찰되지 않았다. IL-12A SNP와 간세포암과의 관련성을 조사한 결과 각각의 SNP 및 +6400/+6624/+7003 haplotype에 따른 HBV 감염 후 간세포암 발생과의 연관성도 관찰되지 않았다. 결론: IL-12A SNP 및 haplotype은 HBV 간염 진행 및 간세포암 발생과 연관성을 보이지 않았다. HBV 감염의 자연 경과에서 숙주의 유전적 인자의 중요성을 상기해 볼때 향후 환자의 유전적 소인에 대한 연구가 더 진행되어야 할 것으로 판단된다.","\"Ⅰ. 서론 = 1 Ⅱ. 연구대상 및 방법 = 3 A. 연구대상 = 3 B. 방법 = 4 1. 유전자형 분석 (Genotyping) = 4 C. 통계분석 = 4 Ⅲ. 결과 = 6 Ⅳ. 고찰 = 11 Ⅴ. 결론 = 14 참고문헌 = 15 ABSTRACT = 18\"","Master"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/1473","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000002689","000000002689"],"dc:language":["ko"],"dc:subject":["B형 간염","Interleukin-12","Single nucleotide polymorphism","B viral hepatits","간세포암"],"dc:title":["Association of Interleukin-12 gene polymorphism with Hepatitis B virus persistnece and Hepatocelluar carcinoma","B형 간염의 만성화 및 간세포암 발생과 Interleukin-12 유전자 다형성"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:22Z"}