{"id":{"repo_id":"ajou","oai_identifier":"oai:repository.ajou.ac.kr:201003/1315"},"canonical_url":"https://search.dev.ndltd.org/etd/ajou/oai:repository.ajou.ac.kr:201003/1315","repository":{"repo_id":"ajou","name":"Ajou University","base_url":"http://repository.ajou.ac.kr/oai/request"},"display":{"title":"The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma","abstract":"\"Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. \"","abstract_html":"&quot;Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p &lt; 0.001). Syndecan-1 expression was significantly greater in CH (p &lt; 0.001) or AH (p &lt; 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p &lt; 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. &quot;","abstract_has_math":false,"creators":["김, 현진"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["유, 희석","대학원 의학과","200424174"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011-01-26T09:54:48Z","date_published":"2011-01-26T09:54:48Z","updated_at":"2026-07-24T00:51:19Z","subjects":["Syndecan-1","자궁내막증식증","자궁내막암"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928","000000010928"],"render_values":[{"text":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928","href":"http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928","code":true},{"text":"000000010928","href":null,"code":true}]}]},"links":{"outbound_url":"http://repository.ajou.ac.kr/handle/201003/1315","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["유, 희석","대학원 의학과","200424174","김, 현진"]},{"key":"dc:creator","label":"Author","values":["김, 현진"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011-01-26T09:54:48Z","2010"]},{"key":"dc:type","label":"Dc Type","values":["Thesis","Theses"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Syndecan-1","자궁내막증식증","자궁내막암"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.ajou.ac.kr/handle/201003/1315","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928","000000010928"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["\"Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. \"","\"ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. INTRODUCTION 1 Ⅱ. PATIENTS AND METHODS 3 A. Patients and tissue samples 3 B. Immunohistochemical study 5 C. Staining evaluation 5 D. Statistical analysis 6 Ⅲ. RESULTS 7 A. Patient characteristics 7 B. Expression of syndecan-1 8 Ⅳ. DISCUSSION 12 REFERENCE 15 국문요약 19 \"","Doctor"]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma","자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성"]}]}],"canonical_facts":{"dc:contributor":["유, 희석","대학원 의학과","200424174","김, 현진"],"dc:creator":["김, 현진"],"dc:date":["2011-01-26T09:54:48Z","2010"],"dc:description":["\"Objective: Aberrant expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer progression in patients with endometrial hyperplasia. Methods: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues. We analyzed specimens from patients with normal endometrium (NE, n=10) as controls, and those of simple hyperplasia (SH, n=20), complex hyperplasia without atypia (CH, n=20), atypical hyperplasia (AH, n=20), and endometrial cancer (EC, n=31). Results: The mean rank of expression scores based on the frequency of syndecan-1 staining were 31.6, 20.5, 52.9, 72.1, and 62.1 for NE, SH, CH, AH and EC, respectively (p < 0.001). Syndecan-1 expression was significantly greater in CH (p < 0.001) or AH (p < 0.001) than in SH, and significantly greater in AH compared to CH (p=0.028). Syndecan-1 is more frequently expressed in CH (p=0.042), AH (p < 0.001), or EC (p=0.002) than in NE. Syndecan-1 expression did not differ significantly between NE and SH (p=0.248). Conclusion: Syndecan-1 expression appears to be useful as a predictive indicator of endometrial carcinogenesis from normal endometrium or endometrial hyperplasia to endometrial cancer. \"","\"ABSTRACT ⅰ TABLE OF CONTENTS ⅲ LIST OF FIGURES ⅳ LIST OF TABLES ⅴ Ⅰ. INTRODUCTION 1 Ⅱ. PATIENTS AND METHODS 3 A. Patients and tissue samples 3 B. Immunohistochemical study 5 C. Staining evaluation 5 D. Statistical analysis 6 Ⅲ. RESULTS 7 A. Patient characteristics 7 B. Expression of syndecan-1 8 Ⅳ. DISCUSSION 12 REFERENCE 15 국문요약 19 \"","Doctor"],"dc:format":["application/pdf"],"dc:identifier":["http://repository.ajou.ac.kr/handle/201003/1315","http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010928","000000010928"],"dc:language":["en"],"dc:subject":["Syndecan-1","자궁내막증식증","자궁내막암"],"dc:title":["The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma","자궁내막증식증 및 자궁내막암과 syndecan-1의 발현과의 관련성"],"dc:type":["Thesis","Theses"]},"updated_at":"2026-07-24T00:51:19Z"}