Evaluation of 18F FDG-PET/CT in Patients with Gastric Signet Ring Cell Carcinoma : Correlation with GLUT-1 Expression and Histologic Finding

PURPOSE: Gastric signet ring cell carcinoma (GSRC) is known to have low FDG uptake. The aim of the study was to investigate the relation between FDG uptake and glucose transporter-1 (GLUT-1) expression in GSRC patients. MATERIALS AND METHODS: Forty patients (28 men, mean age 54±12) with histologically confirmed GSRC who underwent a pre-operative PET/CT were enrolled. The maximum standardized uptake value (SUVmax) was compared with histological parameters and GLUT-1 expression. GLUT-1 expression was divided into membranous or cytoplasmic group. RESULT: The SUVmax was significantly higher in membranous group than in cytoplasmic group (6.06 ± 2.79 vs. 3.67 ± 1.54, p=0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage and tumor size were also correlated with SUVmax. On the other hand, age, sex and the presence of distant metastasis were not related with SUVmax. Multivariate analysis revealed that the membranous GLUT-1 expression and the extent of LN metastasis were the independent predictive factor of high FDG uptake in GSRC. SUVmax predicted the presence of membranous expression of GLUT-1 with moderate specificity (82.6%, cut-off = 4.3). CONCLUSION: This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.

Author dc:creator

• 최, 봉회

Contributors dc:contributor

• 윤, 준기
• 대학원 의학과
• 200724307

• signet ring cell
• stomach cancer
• FDG
• glucose transporter-1

Language dc:language

en

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000010950
000000010950

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/1292