Comparison of clinical outcome after revascularization versus conservative treatment in patients with borderline fractional flow reserve measurements
type: CreativeWork
description: BACKGROUND: Measurement of fractional flow reserve (FFR) is useful tool for assessing the functional severity of coronary artery stenosis and for clinical decision of treatment strategy. Many studies have shown that FFR measurement <0.75 is specific for ischemia, but there is a controversy about whether we need to intervene the lesion of FFR measurement 0.75-0.80 or not. The objective of this study is to compare the clinical outcomes of revascularization versus conservative treatment in the borderline FFR measurement lesions. METHODS: We used the FFR-Registry database out of 4 centers in Korea. In 267 patients (mean age 62 ± 10 years, male 69%), 277 lesions (LAD, 213; LCX, 40; RCA, 24) with FFR measurement between 0.75 and 0.80 (mean 0.77±0.02) were included in this study. The rate of major adverse cardiac events (MACE; death, myocardial infarction, targe lesion revascularization) and target lesion related events (TLRE; FFR-evaluated lesion revascularization, FFR-evaluated lesion-related myocardial infarction) were evaluated at 1 year follow up. Sixty-seven lesions from 66 patients were deferred from revascularization (Conservative group) and 210 lesions from 201 patients were treated with percutaneous coronary intervention (PCI group). RESULTS: For 1 year follow-up, 4 cases of TLRE (4 cases of FFR-evaluated lesion revascularization and no case of FFR-evaluated lesion-related myocardial infarction) from 4 patients occurred in the Conservative group and 8 cases of TLRE (8 cases of FFR-evaluated lesion revascularization and 1 case of FFR-evaluated lesion-related myocardial infarction) from 8 patients occurred in the PCI group. Five cases of MACE (1 case of death, no case of myocardial infarction and 5 cases of target lesion revascularization) occurred in the Conservative group and 13 cases of MACE (4 cases of death, 2 cases of myocardial infarction and 9 cases of target lesion revascularization) occurred in the PCI group. Using Cox proportional hazard model, there was…
abstract: BACKGROUND: Measurement of fractional flow reserve (FFR) is useful tool for assessing the functional severity of coronary artery stenosis and for clinical decision of treatment strategy. Many studies have shown that FFR measurement <0.75 is specific for ischemia, but there is a controversy about whether we need to intervene the lesion of FFR measurement 0.75-0.80 or not. The objective of this study is to compare the clinical outcomes of revascularization versus conservative treatment in the borderline FFR measurement lesions. METHODS: We used the FFR-Registry database out of 4 centers in Korea. In 267 patients (mean age 62 ± 10 years, male 69%), 277 lesions (LAD, 213; LCX, 40; RCA, 24) with FFR measurement between 0.75 and 0.80 (mean 0.77±0.02) were included in this study. The rate of major adverse cardiac events (MACE; death, myocardial infarction, targe lesion revascularization) and target lesion related events (TLRE; FFR-evaluated lesion revascularization, FFR-evaluated lesion-related myocardial infarction) were evaluated at 1 year follow up. Sixty-seven lesions from 66 patients were deferred from revascularization (Conservative group) and 210 lesions from 201 patients were treated with percutaneous coronary intervention (PCI group). RESULTS: For 1 year follow-up, 4 cases of TLRE (4 cases of FFR-evaluated lesion revascularization and no case of FFR-evaluated lesion-related myocardial infarction) from 4 patients occurred in the Conservative group and 8 cases of TLRE (8 cases of FFR-evaluated lesion revascularization and 1 case of FFR-evaluated lesion-related myocardial infarction) from 8 patients occurred in the PCI group. Five cases of MACE (1 case of death, no case of myocardial infarction and 5 cases of target lesion revascularization) occurred in the Conservative group and 13 cases of MACE (4 cases of death, 2 cases of myocardial infarction and 9 cases of target lesion revascularization) occurred in the PCI group. Using Cox proportional hazard model, there was…
author: 서, 경우
language: en
keywords: fractional flow reserve, coronary artery disease, percutaneous coronary intervention, medical treatment, 분획혈류 예비력, 심혈관 협착질환, 재관류술, 보존적 약물치료
date published: 2014-11-12T01:25:21Z
date modified: 2026-07-24T00:51:44Z
provider: Ajou University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Ajou University