Brain regeneration in a hypoxic-ischemic mouse model

Cerebral palsy (CP) is a non-progressive motor condition which causes physical disability in human development. Hypoxic-ischemia (HI) is believed to account for a majority of cerebral palsy cases. During HI brain injury neurons, glia and endothelial cells are damaged and lose their function or die. But unexpectedly there are greater numbers of infants do not suffer lasting neurological impairment. One of the reasons may be the formation of new cells in the damaged tissue. Hypoxic ischemic lesion was observed in striatum, hippocampus and cortex region, and damaged tissue was getting worse up to day 4 after HI (p11). Numerous apoptotic and necrotic neuron has been observed in early phage after the injury, but two weeks later (p21), tissue integrity and neuron cells looked similar as shown in normal brain, Also, substantial endogenous recovery in the damaged cortex was observed in late phage after HI insult. Compared to normal mouse brain, we verified increasing of newly dividing cells in early phase after HI in the area of SVZ, SGS and SC. Furthermore, neural stem cells which are regulated by sonic hedgehog signaling were also significantly increased in neurogenic niche following HI insult. At last, many numbers of neural stem cell was observed in injured cortex and differentiated to neuronal and glial cells in late phage. This recovery mechanism is not yet fully understood, but for the targeting of therapeutic strategies in HI disease, research should be more progressed and improved.

Author dc:creator

• 박, 신영

Contributors dc:contributor

• 서, 해영
• 대학원 의생명과학과
• 201224391

• 허혈성 저산소증
• 소닉헤지호그
• 재생
• Hypoxic-i schemia
• Sonic hedgehog
• Regeneration

Language dc:language

ko

Identifier

http://dcoll.ajou.ac.kr:9080/dcollection/jsp/common/DcLoOrgPer.jsp?sItemId=000000017904
000000017904

OAI identifier oai:identifier

oai:repository.ajou.ac.kr:201003/10872