The role of substance P in cerebral edema associated with rat and human infarction and contusion
type: CreativeWork
description: An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion.
abstract: An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion.
author: Hassan, Islam Khamis Ahmed Mohamed
keywords: substance P; cerebral edema; rats
date published: 2006
date modified: 2026-07-24T00:50:39Z
provider: University of Adelaide
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Adelaide

PropertyValue
property ID: Handle
value: http://hdl.handle.net/2440/69464