{"id":{"repo_id":"adelaide","oai_identifier":"oai:digital.library.adelaide.edu.au:2440/69464"},"canonical_url":"https://search.dev.ndltd.org/etd/adelaide/oai:digital.library.adelaide.edu.au:2440/69464","repository":{"repo_id":"adelaide","name":"University of Adelaide","base_url":"https://digital.library.adelaide.edu.au/server/oai/request"},"display":{"title":"The role of substance P in cerebral edema associated with rat and human infarction and contusion","abstract":"An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion.","abstract_html":"An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion.","abstract_has_math":false,"creators":["Hassan, Islam Khamis Ahmed Mohamed"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006","date_published":"2006","updated_at":"2026-07-24T00:50:39Z","subjects":["substance P; cerebral edema; rats"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2440/69464","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Hassan, Islam Khamis Ahmed Mohamed"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2006"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["substance P; cerebral edema; rats"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2440/69464"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion."]},{"key":"dc:title","label":"Title","values":["The role of substance P in cerebral edema associated with rat and human infarction and contusion"]}]}],"canonical_facts":{"dc:creator":["Hassan, Islam Khamis Ahmed Mohamed"],"dc:date.issued":["2006"],"dc:description.abstract":["An important influence on the severity of both traumatic brain injury (TBI) and stroke is cerebral edema, but its mechanism is poorly understood. Recent evidence suggests that substance P (SP) plays a role in this edema and that injured SP-containing perivascular nerve fibres are involved. A study which examined tissue obtained from rat models and human post mortem infarct and contusion tissue, demonstrated that in all the examined tissue, perivascular SP-IR was present in astrocytic processes rather than in nerve fibres. This implies that perivascular astrocytic processes might be more important than perivascular nerve fibres in any effect that SP may have on the blood brain barrier in the settings of infarction and contusion."],"dc:identifier.uri":["http://hdl.handle.net/2440/69464"],"dc:subject":["substance P; cerebral edema; rats"],"dc:title":["The role of substance P in cerebral edema associated with rat and human infarction and contusion"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T00:50:39Z"}