Identification of a novel role for Eb1 in the regulation of cell growth and G1-S phase progression in Drosophila / by Deborah Coates.

This thesis aimed to characterise the G1-S phase role of Drosophila Eb1, dEb1, which was identified in a cyclin E genetic screen. A dominant modifier screen was undertaken to identify novel regulators of cyclin E, and cell cycle progression using a hypomorphic allele of cyclin E. One suppressor from this screen, Su(DmcycEjp)2.5, was identified as a potential Drosophila homologue of the microtubule binding protein Eb1, dEb1. Southern and northern analysis confirmed that Su(DmcycEjp)2.5 is an allele of dEb1, and other dEb1 alleles were shown to also be able to suppress cyclin Ejp.

Author dc:creator

• Coates, Deborah Patricia

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/2440/21988

OAI identifier oai:identifier

oai:digital.library.adelaide.edu.au:2440/21988