Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.

Studies the capacity of dendritic cells transduced with the immunosuppressive gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small animal models can modify skin graft rejection. In large animals, genetically modified dendritic cells alone were not capable of prolongation of allograft survival, suggesting that these cells may require adjuvant immunosuppressive therapy to be used in future protocols.

Author dc:creator

• Coates, Patrick Toby Hewlett

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/2440/21677

OAI identifier oai:identifier

oai:digital.library.adelaide.edu.au:2440/21677