Design, production and characterisation of IGF-I analogues with increased gastric stability / by Katherine J. Bryant.

The aims of this thesis are to determine the initial cleavage sites of purified pepsin in long-R3-IGF-I and assess whether the resulting cleavages affect biological activity, to design and produce analogues of long-R3-IGF-I which contain amino acid substitutions, to characterise the resulting analogues for pepsin resistance and retention of biological activity and to assess the stability of the long-R3-IGF-I analogues under in vivo conditions using luminal stomach flushings.

Author dc:creator

• Bryant, Katherine J. (Katherine Jane), 1962-

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/2440/19074

OAI identifier oai:identifier

oai:digital.library.adelaide.edu.au:2440/19074