{"id":{"repo_id":"adelaide","oai_identifier":"oai:digital.library.adelaide.edu.au:2440/18998"},"canonical_url":"https://search.dev.ndltd.org/etd/adelaide/oai:digital.library.adelaide.edu.au:2440/18998","repository":{"repo_id":"adelaide","name":"University of Adelaide","base_url":"https://digital.library.adelaide.edu.au/server/oai/request"},"display":{"title":"Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke.","abstract":"The aim of this thesis is to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system.","abstract_html":"The aim of this thesis is to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system.","abstract_has_math":false,"creators":["Tscharke, David C."],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1997,"date_issued":"1997","date_published":"1997","updated_at":"2026-07-24T00:51:10Z","subjects":[],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2440/18998","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Tscharke, David C."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["1997"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2440/18998"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: leaves 141-182.","xi, 182, [36] leaves, [12] leaves of plates : ill. ; 30 cm."]},{"key":"dc:description.abstract","label":"Abstract","values":["The aim of this thesis is to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke."]}]}],"canonical_facts":{"dc:creator":["Tscharke, David C."],"dc:date.issued":["1997"],"dc:description":["Bibliography: leaves 141-182.","xi, 182, [36] leaves, [12] leaves of plates : ill. ; 30 cm."],"dc:description.abstract":["The aim of this thesis is to analyse the molecular events associated with CD8+ T lymphocyte activity in HSV infected sensory ganglia. The role of CD8+ T cells in cytokine responses to ganglionic HSV infection is investigated, with particular reference to the Th1/Th2 paradigm and a known anti-viral mediator, IFN-[gamma]. A non-directed method of mRNA analysis is applied to HSV infected ganglia with the specific aim of identifying transcripts that may be associated with CD8+ T cell activity in the nervous system."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["http://hdl.handle.net/2440/18998"],"dc:language.iso":["en"],"dc:title":["Transcriptional analysis of the role of CD8+ T lymphocytes in acute neural herpes simplex virus infection / David C. Tscharke."],"dc:type":["Thesis"]},"updated_at":"2026-07-24T00:51:10Z"}