Takotsubo Syndrome: Precipitants, Clinical Course and Emerging Treatments
type: CreativeWork
description: Introduction Clinically, patients with Takotsubo Syndrome(TTS) presents similarly to that of acute coronary syndromes(ACS). Recent evidence has demonstrated that not only is TTS a common condition, like ACS, it is also associated with significant morbidity and mortality in the short- and long-term. It is now also recognised that there are various precipitants and risk factors of TTS, and like ACS, this list continues to grow. However, the exact pathophysiology, natural history, as well as treatment options for TTS remain incompletely understood. The studies described in this thesis were carried out to delineate a number of aspects of the precipitation, complications and potential treatment of TTS. Methods We investigated (a)novel risk/precipitating factors for ACS and TTS, (b)prognostic impact of variability in severity of attacks of acute TTS and the rate of myocardial recovery, and (c)pharmacological strategies for limiting severity of acute attacks, as well as accelerating the recovery in TTS. We sought correlations of high ambient temperatures, pollution, and proximity to bushfires(as individual and cumulative stressors) with the incidence of ACS and TTS. We also investigated the impacts of exogenous catecholamines and catecholamine-potentiating drugs(CPD) on TTS. In regards to the impacts of variable severity of acute attacks of TTS, we sought correlations between severity of TTS attacks and the incidence of hypotension acutely, as well as the recovery in quality of life at 3 months’ follow up. Finally, we designed a double-blinded randomised controlled trial to help determine pharmacological strategies for the treatment of TTS. Novel risk/precipitating factors: Incidence of ACS increased with not only increased ambient temperatures in warmer months of the year(rs=0.26, p=0.005), but also in the presence of high ambient temperatures, pollution and bushfires in combination(rs=0.25,p=0.005). We found no significant analogous correlations with TTS presentations ho…
abstract: Introduction Clinically, patients with Takotsubo Syndrome(TTS) presents similarly to that of acute coronary syndromes(ACS). Recent evidence has demonstrated that not only is TTS a common condition, like ACS, it is also associated with significant morbidity and mortality in the short- and long-term. It is now also recognised that there are various precipitants and risk factors of TTS, and like ACS, this list continues to grow. However, the exact pathophysiology, natural history, as well as treatment options for TTS remain incompletely understood. The studies described in this thesis were carried out to delineate a number of aspects of the precipitation, complications and potential treatment of TTS. Methods We investigated (a)novel risk/precipitating factors for ACS and TTS, (b)prognostic impact of variability in severity of attacks of acute TTS and the rate of myocardial recovery, and (c)pharmacological strategies for limiting severity of acute attacks, as well as accelerating the recovery in TTS. We sought correlations of high ambient temperatures, pollution, and proximity to bushfires(as individual and cumulative stressors) with the incidence of ACS and TTS. We also investigated the impacts of exogenous catecholamines and catecholamine-potentiating drugs(CPD) on TTS. In regards to the impacts of variable severity of acute attacks of TTS, we sought correlations between severity of TTS attacks and the incidence of hypotension acutely, as well as the recovery in quality of life at 3 months’ follow up. Finally, we designed a double-blinded randomised controlled trial to help determine pharmacological strategies for the treatment of TTS. Novel risk/precipitating factors: Incidence of ACS increased with not only increased ambient temperatures in warmer months of the year(rs=0.26, p=0.005), but also in the presence of high ambient temperatures, pollution and bushfires in combination(rs=0.25,p=0.005). We found no significant analogous correlations with TTS presentations ho…
author: Ong, Gao Jing
language: en
keywords: Takotsubo Syndrome, acute coronary syndrome, catecholamines
date published: 2022
date modified: 2026-07-24T00:51:13Z
provider: University of Adelaide
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Adelaide

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property ID: Handle
value: https://hdl.handle.net/2440/136031