The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
type: CreativeWork
description: Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of effector and memory cells, how T cells are polarised to a particular fate is poorly understood. One factor that is important for T cell fate decisions in the microanatomical localisation of activated T cells in specific niches that promote T cell differentiation, and this activity is regulated through the specific action of chemokines and chemokine receptors. However, the molecular mechanisms underlying these processes are unclear. Understanding the regulation of CD8⁺ T cell traffcking should reveal key mechanisms in T cell differentiation and protective immunity, and this knowledge would have wide-ranging impacts on the development of vaccines against intracellular pathogens like influenza, where antibody responses provide only short-term protection, and against emerging intracellular pathogens. Thus, the regulation of CD8⁺ T cell traffcking during infection was investigated by focusing on chemokine receptors, which orchestrate lymphocyte migration. The expression of chemokine receptors was investigated in CD8⁺ T cells responding to influenza infection. This revealed that the chemokine receptor CCR2 was highly expressed in CD8⁺ T cells in the mLN, spleen, peripheral blood, and lung parenchyma. Further investigation revealed that CCR2 was expressed within the first T cell division in the mLN, and maintained broad and high expression across all effector and memory T cell subsets. Despite the high expression of CCR2 across CD8⁺ T cell effector and memory subsets, the receptor was dispensable for CD8⁺ T cell differentiation, acquisition of effector potential, and expansion and traffking during viral challenge. Further investigation into the role of CCR2 on circulating memory T…
abstract: Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of effector and memory cells, how T cells are polarised to a particular fate is poorly understood. One factor that is important for T cell fate decisions in the microanatomical localisation of activated T cells in specific niches that promote T cell differentiation, and this activity is regulated through the specific action of chemokines and chemokine receptors. However, the molecular mechanisms underlying these processes are unclear. Understanding the regulation of CD8⁺ T cell traffcking should reveal key mechanisms in T cell differentiation and protective immunity, and this knowledge would have wide-ranging impacts on the development of vaccines against intracellular pathogens like influenza, where antibody responses provide only short-term protection, and against emerging intracellular pathogens. Thus, the regulation of CD8⁺ T cell traffcking during infection was investigated by focusing on chemokine receptors, which orchestrate lymphocyte migration. The expression of chemokine receptors was investigated in CD8⁺ T cells responding to influenza infection. This revealed that the chemokine receptor CCR2 was highly expressed in CD8⁺ T cells in the mLN, spleen, peripheral blood, and lung parenchyma. Further investigation revealed that CCR2 was expressed within the first T cell division in the mLN, and maintained broad and high expression across all effector and memory T cell subsets. Despite the high expression of CCR2 across CD8⁺ T cell effector and memory subsets, the receptor was dispensable for CD8⁺ T cell differentiation, acquisition of effector potential, and expansion and traffking during viral challenge. Further investigation into the role of CCR2 on circulating memory T…
author: Norton, Todd
keywords: Infection, inflammation, monocyte, chemokine, chemokine receptor, CCR2, CCL2
date published: 2021
date modified: 2026-07-24T00:50:39Z
provider: University of Adelaide
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Adelaide

PropertyValue
property ID: Handle
value: https://hdl.handle.net/2440/134560