Silicium Nanodrähte für die extrazelluläre Ableitung elektrischer Aktivität
type: CreativeWork
description: Due to their high surface-to-volume ratio silicon nanowires are promising candidates for highly sensitive biosensors. We designed and fabricated nanowire transistors suitable for the extracellular detection of electrical activity. These sensors were characterized thoroughly and tested with HL-1 and HEK cells. The tests with HL-1 cells which are heart tumor cells spontaneously exhibiting action potentials showed that all physiological characteristics could be detected and explained with previous data. For single-cell coupling experiments we used the HEK cells. By measuring the transfer-function between the interior of the cells and the nanowires we could show that an improvement of the coupling by a factor of up to four is possible. The electrical characterisation is augmented with scanning electron micrographs illustrating mechanical aspects of the cell-nanowire-coupling and confirming the good suitability of the produced devices for cell based sensors. They could be used forbasic research, pharmaceutic studies or novel prosthetic devices.
abstract: Due to their high surface-to-volume ratio silicon nanowires are promising candidates for highly sensitive biosensors. We designed and fabricated nanowire transistors suitable for the extracellular detection of electrical activity. These sensors were characterized thoroughly and tested with HL-1 and HEK cells. The tests with HL-1 cells which are heart tumor cells spontaneously exhibiting action potentials showed that all physiological characteristics could be detected and explained with previous data. For single-cell coupling experiments we used the HEK cells. By measuring the transfer-function between the interior of the cells and the nanowires we could show that an improvement of the coupling by a factor of up to four is possible. The electrical characterisation is augmented with scanning electron micrographs illustrating mechanical aspects of the cell-nanowire-coupling and confirming the good suitability of the produced devices for cell based sensors. They could be used forbasic research, pharmaceutic studies or novel prosthetic devices.
author: Eschermann, Jan Felix
language: ger
keywords: info:eu-repo/classification/ddc/500, Bioelektronik, Elektrophysiologie, Nanotechnologie, Silicium, Nanodraht, Naturwissenschaften, Zell-Transistor-Kopplung, Silicium-Nanodrähte, Cell transistor coupling, silicon nanowires, electrophysiology, bioelectronics, nanotechnology
date published: 2010
date modified: 2026-07-30T19:43:35Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Forschungszentrum Jülich, Zentralbibliothek