Design, development and evaluation of a high spatial density CMOS chip for bidirectional communication with electrogenic cells
type: CreativeWork
description: In this project, we present 2 CMOS chips designed in our institute with the aim of establishing a bio-electronic interface with electrically active cells. A measurement and control setup consisting of electronic components responsible for the control of the chips as well as the digitizazion and processing of the data they provide has also been developed. An intuitive LabView program faciliates the user interaction by allowing the setting of all analog bias voltages and digital controls, which are transmitted to the measurement and control setup by a Dynamic Link Library (DLL) (written in C) using a USB interface. The prospect of using a fingerprint sensor chip as an alternative bio-electrocnic device was also investigated in addition to the development of the said chips and their peripheral systems. Similarly, a measurement and controls setup as well as another LabView software were also implemented for the fingerprint sensor. The 2 afromentioned, in-house designed chips are called Calibur and Zulfiqar, with the latter being the one developed later. Calibur was manufactured with a 3 metal 2 poly (3M2P) 0.5μm technology from ON Semiconductor, while a 5 metal 1 poly (5M1P) 0.35μm technology was chosen for Zulfiqar. Both chips were first simulated using the Cadence IC 5.1.41 software on the circuit level to test their electrical features. Later, their individual layouts were created and evaluated using the Calibre tool (Mentor Graphics). The final fabrication of both chips took place in the cleanroom facillities of ON Semiconductor through the Europractice membership of our institute. The first chip, Calibur, was developed by Dr. Mathias Schindler during his PhD. A 64x64 pixel (12.5μm pitch) array was implemented at the center of the chip, followed by a bank of 64 amplifiers (1 per row of the array) to ist right hand side. These amplifiers carried out the on-chip amplification of the analog signals recorded from electrogenic cells, prior to their transfer to the measur…
abstract: In this project, we present 2 CMOS chips designed in our institute with the aim of establishing a bio-electronic interface with electrically active cells. A measurement and control setup consisting of electronic components responsible for the control of the chips as well as the digitizazion and processing of the data they provide has also been developed. An intuitive LabView program faciliates the user interaction by allowing the setting of all analog bias voltages and digital controls, which are transmitted to the measurement and control setup by a Dynamic Link Library (DLL) (written in C) using a USB interface. The prospect of using a fingerprint sensor chip as an alternative bio-electrocnic device was also investigated in addition to the development of the said chips and their peripheral systems. Similarly, a measurement and controls setup as well as another LabView software were also implemented for the fingerprint sensor. The 2 afromentioned, in-house designed chips are called Calibur and Zulfiqar, with the latter being the one developed later. Calibur was manufactured with a 3 metal 2 poly (3M2P) 0.5μm technology from ON Semiconductor, while a 5 metal 1 poly (5M1P) 0.35μm technology was chosen for Zulfiqar. Both chips were first simulated using the Cadence IC 5.1.41 software on the circuit level to test their electrical features. Later, their individual layouts were created and evaluated using the Calibre tool (Mentor Graphics). The final fabrication of both chips took place in the cleanroom facillities of ON Semiconductor through the Europractice membership of our institute. The first chip, Calibur, was developed by Dr. Mathias Schindler during his PhD. A 64x64 pixel (12.5μm pitch) array was implemented at the center of the chip, followed by a bank of 64 amplifiers (1 per row of the array) to ist right hand side. These amplifiers carried out the on-chip amplification of the analog signals recorded from electrogenic cells, prior to their transfer to the measur…
author: Yegin, Ugur
language: eng
keywords: info:eu-repo/classification/ddc/620, Bioelektronik, CMOS, Nervenzelle, High-k-Dielektrikum, Biochip, Mixed-Signal-Schaltung, Ingenieurwissenschaften, Zell-Chip Interface, Neuron, HfO2, TiO2, Ta2O5, Al2O3, bio-chip, neuron-chip, differential amplifier, in-pixel amplification, on-chip amplification, high-k, electrogenic cell, extracellular recording, extracellular stimulation, bi-directional communication, high density, high spatial resolution
date published: 2012
date modified: 2026-07-30T19:43:28Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University