Untersuchung der parodontalen Manifestation von Morbus Crohn unter Berücksichtigung des NOD2(CARD15)-Genotyps und der Mikrobiologie
type: CreativeWork
description: A correlation between crohn´s disease and periodontitis seems possible, because of the similarity concerning their clinical characterization. Previous studies which have dealt with this matter had different results.There are only a few studies that deal with patients who are only diseased with periodontis and crohns disease without other illnesses. Over the last years three genetic variations in the NOD2(Card15) genotype was associated with the crohn´s disease. The mutated gene produces a modified NOD2 protein which causes an unregulated inflammation. It has not been researched yet if there is an effection to the periodontal status. The aim of this study was to find out the effection of the NOD2(Card15) genotype mutation regarding the periodonal status and the microbiology of patients with crohns´s disease. 150 patients with crohn´s disease were recruited. Among other things probing depth and changes in the oral mucosa were detected. Samples from the periodontal pathogenic germs were taken with paper points and detected with the Dot-blotting hybridisation method. To find the NOD2(Card15) genetic mutation, blood samples were taken and were analysed by the TaqMan®-Assays. The connection between the clinical, microbiological and demographic parameters were figured out with a regression analysis. There were no statistically significant findings in the evaluation between the NOD2(Card15) gene mutation and the probing depth or attachment level. Among the patients the frequency of periodontits was high, but the severity was low or moderate.The important result was a high germ number of all periodontal pathagenous germs especially fom campylobactrer rectus. Even a high number of periodontal germs was found in healthy pockets. The quality and quantity of these germs were not statistically significant with the NOD2(Card15) genetic mutation. However the crohns disease seems to offer good living conditions for the germs. It is possible that the examined germs differ from the kn…
abstract: A correlation between crohn´s disease and periodontitis seems possible, because of the similarity concerning their clinical characterization. Previous studies which have dealt with this matter had different results.There are only a few studies that deal with patients who are only diseased with periodontis and crohns disease without other illnesses. Over the last years three genetic variations in the NOD2(Card15) genotype was associated with the crohn´s disease. The mutated gene produces a modified NOD2 protein which causes an unregulated inflammation. It has not been researched yet if there is an effection to the periodontal status. The aim of this study was to find out the effection of the NOD2(Card15) genotype mutation regarding the periodonal status and the microbiology of patients with crohns´s disease. 150 patients with crohn´s disease were recruited. Among other things probing depth and changes in the oral mucosa were detected. Samples from the periodontal pathogenic germs were taken with paper points and detected with the Dot-blotting hybridisation method. To find the NOD2(Card15) genetic mutation, blood samples were taken and were analysed by the TaqMan®-Assays. The connection between the clinical, microbiological and demographic parameters were figured out with a regression analysis. There were no statistically significant findings in the evaluation between the NOD2(Card15) gene mutation and the probing depth or attachment level. Among the patients the frequency of periodontits was high, but the severity was low or moderate.The important result was a high germ number of all periodontal pathagenous germs especially fom campylobactrer rectus. Even a high number of periodontal germs was found in healthy pockets. The quality and quantity of these germs were not statistically significant with the NOD2(Card15) genetic mutation. However the crohns disease seems to offer good living conditions for the germs. It is possible that the examined germs differ from the kn…
author: Granzow, Marie Pradheepa
language: ger
keywords: info:eu-repo/classification/ddc/610, Morbus Crohn, Parodontitis, Medizin, NOD2, Crohn´s disease, periodontitis
date published: 2007
date modified: 2026-07-30T19:43:28Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University