Expression und Verteilung von VIP, Substanz P, CGRP und Bombesin im Larynx und der oberen Trachea
type: CreativeWork
description: The aim of the present immunohistochemical study was to investigate the expression and the distribution pattern of the neuropeptides vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide and bombesin as well in 25 pieces of human tracheal tissue as in 10 pieces of human vocal cord tissue. The results indicated that the larynx as well as the trachea are containing the studied neuropeptides. The expression of these neuropeptides concerning histological structures were comparable to each other in both tissues. There was a strong immunoreactivity around seromucosal glands, blood vessels and within the epithelium but low concentrations within nerve fibers. The concentrations of the studied peptides by immunohistochemical methods increased in the following order: VIP < SP < CGRP < Bombesin. Some effects caused by these peptides like vasodilatation and hypersecretion seem to infuence the development of inflammations and allergical diseases. In healthy human trachea the neuropeptide bombesin could be detected for the first time. It could be found in a high concentration within the basal membrane of the epithelium. The fact that bombesin influences different growth factors might be an indication to its responsibility concerning the formation of scars or stenosis in tracheal tissue. Since the mechanisms and the significance of neuropeptide reactivity in the human trachea and the human larynx are not completely understood yet, further studies are necessary.
abstract: The aim of the present immunohistochemical study was to investigate the expression and the distribution pattern of the neuropeptides vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide and bombesin as well in 25 pieces of human tracheal tissue as in 10 pieces of human vocal cord tissue. The results indicated that the larynx as well as the trachea are containing the studied neuropeptides. The expression of these neuropeptides concerning histological structures were comparable to each other in both tissues. There was a strong immunoreactivity around seromucosal glands, blood vessels and within the epithelium but low concentrations within nerve fibers. The concentrations of the studied peptides by immunohistochemical methods increased in the following order: VIP < SP < CGRP < Bombesin. Some effects caused by these peptides like vasodilatation and hypersecretion seem to infuence the development of inflammations and allergical diseases. In healthy human trachea the neuropeptide bombesin could be detected for the first time. It could be found in a high concentration within the basal membrane of the epithelium. The fact that bombesin influences different growth factors might be an indication to its responsibility concerning the formation of scars or stenosis in tracheal tissue. Since the mechanisms and the significance of neuropeptide reactivity in the human trachea and the human larynx are not completely understood yet, further studies are necessary.
author: Schön, Simone
language: ger
keywords: info:eu-repo/classification/ddc/610, Neuropeptide, Immunhistochemie, Larynx, Trachea, Medizin, neuropeptides, immunohistochemistry
date published: 2007
date modified: 2026-07-30T19:43:28Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University