{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:62091"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:62091","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Partielle Flüssigkeitsbeatmung im Vergleich zur konventionellen Beatmung : Auswirkungen auf Gasaustausch und Lungenpathologie im lungengesunden Neugeborenen-Tiermodell","abstract":"Objective: To evaluate the effects of single (SLV), continuous partial liquid ventilation (PLV) and conventional ventilation on gas exchange and lung injury in a newborn healthy animal model. Design: Prospective, controlled, in vivo animal laboratory study. Setting: Research laboratory in a university setting Subjects: 19 newborn healthy male piglets (mean weight 1,9 kg, age 1-3 days) Interventions: The piglets were anesthetized, intubated und instrumented with vascular catheters. They were randomized in 3 groups: animals receiving 1 hour session of PLV followed by 23 h of CV (SLV), animals receiving continuous PLV over 24 hours (LV), conventionally ventilated animals over 24 hours (CV). The oxygenation index (OI), PaO2/FiO2 ratio, Ventilationindex (VEI) and pH were determined by beginning and hourly during the 24h course. After 24 hours the lungs were removed for histopathological examination. Measurements and main results: The CV group provided the best outcaome (p<0,05) with a continuously stable gas exchange over the 24h period. Between the LV and SLV groups no differences in PaO2/FiO2 ratio were observed however after 6h the OI and VEI deteriorated significantly in the SLV group (p< 0,04 and p< 0,01). CV animals demonstrated significantly higher signs of atelectasis in both upper (p<0,01)and lower (p<0,02) lobes compared to the liquid ventilated groups. A semi-quantitative lung injury score revealed most severe lung damage in the lower lobes of the SLV group compared to the upper lobes (p<0,01) and to the LV group (p<0,006). Conclusion: A prophylactic treatment with PLV led to an impaired gas exchange during the 24 h study. Continuous PLV provided though the best histopathologic outcome.","abstract_html":"Objective: To evaluate the effects of single (SLV), continuous partial liquid ventilation (PLV) and conventional ventilation on gas exchange and lung injury in a newborn healthy animal model. Design: Prospective, controlled, in vivo animal laboratory study. Setting: Research laboratory in a university setting Subjects: 19 newborn healthy male piglets (mean weight 1,9 kg, age 1-3 days) Interventions: The piglets were anesthetized, intubated und instrumented with vascular catheters. They were randomized in 3 groups: animals receiving 1 hour session of PLV followed by 23 h of CV (SLV), animals receiving continuous PLV over 24 hours (LV), conventionally ventilated animals over 24 hours (CV). The oxygenation index (OI), PaO2/FiO2 ratio, Ventilationindex (VEI) and pH were determined by beginning and hourly during the 24h course. After 24 hours the lungs were removed for histopathological examination. Measurements and main results: The CV group provided the best outcaome (p&lt;0,05) with a continuously stable gas exchange over the 24h period. Between the LV and SLV groups no differences in PaO2/FiO2 ratio were observed however after 6h the OI and VEI deteriorated significantly in the SLV group (p&lt; 0,04 and p&lt; 0,01). CV animals demonstrated significantly higher signs of atelectasis in both upper (p&lt;0,01)and lower (p&lt;0,02) lobes compared to the liquid ventilated groups. A semi-quantitative lung injury score revealed most severe lung damage in the lower lobes of the SLV group compared to the upper lobes (p&lt;0,01) and to the LV group (p&lt;0,006). Conclusion: A prophylactic treatment with PLV led to an impaired gas exchange during the 24 h study. Continuous PLV provided though the best histopathologic outcome.","abstract_has_math":false,"creators":["Staikou, Elli-Amalia"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Merz, Ulrich"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2005,"date_issued":"2005","date_published":"2005","updated_at":"2026-07-30T19:43:19Z","subjects":["info:eu-repo/classification/ddc/610","Medizin","Flüssigkeitsbeatmung","BPD","PLV"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123685%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123685%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123685%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/62091","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Merz, Ulrich"]},{"key":"dc:creator","label":"Author","values":["Staikou, Elli-Amalia"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2005"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-20050573"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Medizin","Flüssigkeitsbeatmung","BPD","PLV"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/62091","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123685%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Objective: To evaluate the effects of single (SLV), continuous partial liquid ventilation (PLV) and conventional ventilation on gas exchange and lung injury in a newborn healthy animal model. Design: Prospective, controlled, in vivo animal laboratory study. Setting: Research laboratory in a university setting Subjects: 19 newborn healthy male piglets (mean weight 1,9 kg, age 1-3 days) Interventions: The piglets were anesthetized, intubated und instrumented with vascular catheters. They were randomized in 3 groups: animals receiving 1 hour session of PLV followed by 23 h of CV (SLV), animals receiving continuous PLV over 24 hours (LV), conventionally ventilated animals over 24 hours (CV). The oxygenation index (OI), PaO2/FiO2 ratio, Ventilationindex (VEI) and pH were determined by beginning and hourly during the 24h course. After 24 hours the lungs were removed for histopathological examination. Measurements and main results: The CV group provided the best outcaome (p<0,05) with a continuously stable gas exchange over the 24h period. Between the LV and SLV groups no differences in PaO2/FiO2 ratio were observed however after 6h the OI and VEI deteriorated significantly in the SLV group (p< 0,04 and p< 0,01). CV animals demonstrated significantly higher signs of atelectasis in both upper (p<0,01)and lower (p<0,02) lobes compared to the liquid ventilated groups. A semi-quantitative lung injury score revealed most severe lung damage in the lower lobes of the SLV group compared to the upper lobes (p<0,01) and to the LV group (p<0,006). Conclusion: A prophylactic treatment with PLV led to an impaired gas exchange during the 24 h study. Continuous PLV provided though the best histopathologic outcome."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 59 S. (2005). = Aachen, Techn. Hochsch., Diss., 2005"]},{"key":"dc:title","label":"Title","values":["Partielle Flüssigkeitsbeatmung im Vergleich zur konventionellen Beatmung : Auswirkungen auf Gasaustausch und Lungenpathologie im lungengesunden Neugeborenen-Tiermodell"]}]}],"canonical_facts":{"dc:contributor":["Merz, Ulrich"],"dc:coverage":["DE"],"dc:creator":["Staikou, Elli-Amalia"],"dc:date":["2005"],"dc:description":["Objective: To evaluate the effects of single (SLV), continuous partial liquid ventilation (PLV) and conventional ventilation on gas exchange and lung injury in a newborn healthy animal model. Design: Prospective, controlled, in vivo animal laboratory study. Setting: Research laboratory in a university setting Subjects: 19 newborn healthy male piglets (mean weight 1,9 kg, age 1-3 days) Interventions: The piglets were anesthetized, intubated und instrumented with vascular catheters. They were randomized in 3 groups: animals receiving 1 hour session of PLV followed by 23 h of CV (SLV), animals receiving continuous PLV over 24 hours (LV), conventionally ventilated animals over 24 hours (CV). The oxygenation index (OI), PaO2/FiO2 ratio, Ventilationindex (VEI) and pH were determined by beginning and hourly during the 24h course. After 24 hours the lungs were removed for histopathological examination. Measurements and main results: The CV group provided the best outcaome (p<0,05) with a continuously stable gas exchange over the 24h period. Between the LV and SLV groups no differences in PaO2/FiO2 ratio were observed however after 6h the OI and VEI deteriorated significantly in the SLV group (p< 0,04 and p< 0,01). CV animals demonstrated significantly higher signs of atelectasis in both upper (p<0,01)and lower (p<0,02) lobes compared to the liquid ventilated groups. A semi-quantitative lung injury score revealed most severe lung damage in the lower lobes of the SLV group compared to the upper lobes (p<0,01) and to the LV group (p<0,006). Conclusion: A prophylactic treatment with PLV led to an impaired gas exchange during the 24 h study. Continuous PLV provided though the best histopathologic outcome."],"dc:identifier":["https://publications.rwth-aachen.de/record/62091","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123685%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-20050573"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 59 S. (2005). = Aachen, Techn. Hochsch., Diss., 2005"],"dc:subject":["info:eu-repo/classification/ddc/610","Medizin","Flüssigkeitsbeatmung","BPD","PLV"],"dc:title":["Partielle Flüssigkeitsbeatmung im Vergleich zur konventionellen Beatmung : Auswirkungen auf Gasaustausch und Lungenpathologie im lungengesunden Neugeborenen-Tiermodell"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:43:19Z"}