Optimierung der Kapazität von Adsorbern für medizinische Zwecke mittels eines flexiblen Adsorbergehäuses
Aim: Packed adsorber columns are densely packed whereas the design of unpacked columns allows mixing of the adsorber material using trapped air. Through this feature, the dead space of the unpacked column is higher and separation between plasma and elution fluids is less well defined. But contrary to unpacked columns in well packed column fluid channels may occur. This channeling phenomenon may affect the quantity of solute adsorbed in a negative manner. As the result of channel formation the adsorption capacity and the flow through of the packed column will decrease rapidly during the treatment. Method: A cartridge has been constructed with a flexible wall. With an external system, which can be used between the treatments, the adsorber cartridge volume can be changed so that plasma does not go lost. And on the other hand the channels can be destroyed and the columns can be packed again. Results: In the case that adsorption capacity or flow through the column is inadequate, it is not necessary to reject the column, because between treatments a system is installed to regenerate the column. In this regeneration process the volume of the column is increased so that the sorbent inside the column can be moved. The availability of more space makes it possible to destroy the channels and to regenerate all sorbent particles. After regeneration the column volume is decreased to a minimum, so that the column is packed again like a packed column. Conclusion: With the flexible cartridge we present a column with low plasma loss and an increased efficiency.
info:eu-repo/classification/ddc/610, Medizin, Apherese, Adsorption
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