Synthese und Charakterisierung von bioabbaubaren Polymeren auf der Basis von Polydepsipeptiden
type: CreativeWork
description: The thesis deals with the synthesis and characterization of bioresorbable polymers based on polydepsipeptides. Four different types of polydepsipeptide-polyether block copolymers were synthesized via ring-opening polymerization of morpholine-2,5-dione derivatives. The dependence of the macroscopic properties of the block copolymers on their structure is discussed. A new method for the synthesis of polydepsipeptides, i.e. the enzyme-catalyzed ring-opening polymerization of morpholine-2,5-dione derivatives, is presented. Synthesis and characterization of new block copolymers based on polydepsipeptides ABA block copolymers with polydepsipeptides (A) and poly(ethylene oxide) ( = 6000, PEO, B) blocks were synthesized via ring-opening polymerization of 3(S)-sec-butyl-morpholine-2,5-dione or 3(S)-isobutyl-morpholine-2,5-dione in the presence of hydroxytelechelic poly(ethylene oxide) with stannous octoate as a catalyst. of the resulting copolymers increases with increasing amount of morpholine-2,5-dione derivatives. No racemization of the isoleucine or leucine residue takes place during both homopolymerization and polymerization of morpholine-2,5-dione derivatives in the presence of PEO and Sn(oct)2. The melting temperature of the poly(Glc-Leu) segments in poly(Glc-Leu)-PEO-poly(Glc-Leu) block copolymers increases with increasing length of the poly(Glc-Leu) blocks. The poly(Glc-Leu) block crystallizes first upon cooling from the melt. This leads to imperfect crystallization or no crystallization of the PEO block. The melting temperature of the PEO block is lower than that of the homopolymer, and the crystallinity of the PEO block decreases with increasing length of the polydepsipeptide blocks in both triblock copolymers. Static contact angle measurement with water clearly reveal that the hydrophilicity of the resulting copolymers increases greatly with increasing PEO content in the copolymers. Four different types of polydepsipeptide-polyether block copolymers were synthesi…
abstract: The thesis deals with the synthesis and characterization of bioresorbable polymers based on polydepsipeptides. Four different types of polydepsipeptide-polyether block copolymers were synthesized via ring-opening polymerization of morpholine-2,5-dione derivatives. The dependence of the macroscopic properties of the block copolymers on their structure is discussed. A new method for the synthesis of polydepsipeptides, i.e. the enzyme-catalyzed ring-opening polymerization of morpholine-2,5-dione derivatives, is presented. Synthesis and characterization of new block copolymers based on polydepsipeptides ABA block copolymers with polydepsipeptides (A) and poly(ethylene oxide) ( = 6000, PEO, B) blocks were synthesized via ring-opening polymerization of 3(S)-sec-butyl-morpholine-2,5-dione or 3(S)-isobutyl-morpholine-2,5-dione in the presence of hydroxytelechelic poly(ethylene oxide) with stannous octoate as a catalyst. of the resulting copolymers increases with increasing amount of morpholine-2,5-dione derivatives. No racemization of the isoleucine or leucine residue takes place during both homopolymerization and polymerization of morpholine-2,5-dione derivatives in the presence of PEO and Sn(oct)2. The melting temperature of the poly(Glc-Leu) segments in poly(Glc-Leu)-PEO-poly(Glc-Leu) block copolymers increases with increasing length of the poly(Glc-Leu) blocks. The poly(Glc-Leu) block crystallizes first upon cooling from the melt. This leads to imperfect crystallization or no crystallization of the PEO block. The melting temperature of the PEO block is lower than that of the homopolymer, and the crystallinity of the PEO block decreases with increasing length of the polydepsipeptide blocks in both triblock copolymers. Static contact angle measurement with water clearly reveal that the hydrophilicity of the resulting copolymers increases greatly with increasing PEO content in the copolymers. Four different types of polydepsipeptide-polyether block copolymers were synthesi…
author: Feng, Yakai
language: eng
keywords: info:eu-repo/classification/ddc/540, Chemie, Blockcopolymere, Mikrobielle Abbaubarkeit, Depsipeptide, Ringöffnungspolymerisation, Enzymkatalyse
date published: 2000
date modified: 2026-07-30T19:43:19Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University