Untersuchungen zu Telomerlängen bei Hodgkin- und Reed-Sternberg-Zellen
type: CreativeWork
description: As shown by the TRAP-assay, Hodgkin- and Reed-Sternberg cells exhibit telomerase activity, offering an unlimited proliferative capacity to them. The catalytic subunit of this enzyme can be inhibited by reverse transcriptase inhibitors. Analyses of telomere length directly by the Southern blot technique and indirectly by Telomere-FISH could demonstrate progressive telomere erosion. Ultrastructural analyses could show that cell death by telomerase inhibition is neither an apoptotic nor a paraapoptotic but a necrotic cell death. This phenomenon separates HRS-cells from other tumor cells and has not been described yet.
abstract: As shown by the TRAP-assay, Hodgkin- and Reed-Sternberg cells exhibit telomerase activity, offering an unlimited proliferative capacity to them. The catalytic subunit of this enzyme can be inhibited by reverse transcriptase inhibitors. Analyses of telomere length directly by the Southern blot technique and indirectly by Telomere-FISH could demonstrate progressive telomere erosion. Ultrastructural analyses could show that cell death by telomerase inhibition is neither an apoptotic nor a paraapoptotic but a necrotic cell death. This phenomenon separates HRS-cells from other tumor cells and has not been described yet.
author: Balta, Zeynep
language: ger
keywords: info:eu-repo/classification/ddc/610, Medizin, Lymphogranulomatose, Telomer, Telomerase, Apoptosis, Nekrose, Zelltod, Reverse Transkriptase, Morbus Hodgkin, Hodgkin´s disease, telomere, necrosis
date published: 2006
date modified: 2026-07-30T19:43:10Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University