The development of bioabsorbable hydrogels on the basis of polyester grafted poly(vinyl alcohol)
type: CreativeWork
description: The present work describes the synthesis and characterization of amorphous and covalently crosslinked polymer systems based on poly(vinyl alcohol) and polyesters. The hydrogels prepared are biocompatible and hydrolytically degradable. The macroscopic properties, primarily the degradation rate, mass loss, water uptake, mechanical properties of the hydrogels can be tailored by variation of the polyester composition and the network structure. Covalently crossliked polymer networks were synthesized via a three step reaction. Short polyester chains were initially prepared by ring opening polymerization of lactide and glycolide. Hydroxyethyl methacrylate was used as an initiator which enables the simultaneous introduction of double bonds into the system. In the second step the hydroxy end groups of the polyesters were transferred into carboxylic groups by reaction with succinic anhydride. The third step was the grafting of the polyester chains onto the poly(vinyl alcohol) chain. Finally, crosslinking was accomplished through reaction of the double bonds using a free radical initiator. The chemical composition of the networks was investigated by means of IR and NMR spectroscopy, whereas NMR was used to pursue each step of synthesis and indicated its good control. The IR spectroscopy gave insight into the composition of the networks by means of the characteristic bands at 3300 cm-1 (OH), 1750 cm-1 (C=O), as well as in the fingerprint region. DSC measurements showed only one characteristic transition temperature in networks, the glass transition temperature Tg, in the range between 51 and 71°C .The surface properties of hydrogel films were investigated using the captive-bubble method. Statistic contact angles were found to be between 28° and 45°. Mechanical testing showed Young’s modulus E to have values between 0.01 and 103 MPa. Biocompatibility was tested on hydrogel type P with the assistance of primary human dermal fibroblasts (hF) cells, which after four days of incubat…
abstract: The present work describes the synthesis and characterization of amorphous and covalently crosslinked polymer systems based on poly(vinyl alcohol) and polyesters. The hydrogels prepared are biocompatible and hydrolytically degradable. The macroscopic properties, primarily the degradation rate, mass loss, water uptake, mechanical properties of the hydrogels can be tailored by variation of the polyester composition and the network structure. Covalently crossliked polymer networks were synthesized via a three step reaction. Short polyester chains were initially prepared by ring opening polymerization of lactide and glycolide. Hydroxyethyl methacrylate was used as an initiator which enables the simultaneous introduction of double bonds into the system. In the second step the hydroxy end groups of the polyesters were transferred into carboxylic groups by reaction with succinic anhydride. The third step was the grafting of the polyester chains onto the poly(vinyl alcohol) chain. Finally, crosslinking was accomplished through reaction of the double bonds using a free radical initiator. The chemical composition of the networks was investigated by means of IR and NMR spectroscopy, whereas NMR was used to pursue each step of synthesis and indicated its good control. The IR spectroscopy gave insight into the composition of the networks by means of the characteristic bands at 3300 cm-1 (OH), 1750 cm-1 (C=O), as well as in the fingerprint region. DSC measurements showed only one characteristic transition temperature in networks, the glass transition temperature Tg, in the range between 51 and 71°C .The surface properties of hydrogel films were investigated using the captive-bubble method. Statistic contact angles were found to be between 28° and 45°. Mechanical testing showed Young’s modulus E to have values between 0.01 and 103 MPa. Biocompatibility was tested on hydrogel type P with the assistance of primary human dermal fibroblasts (hF) cells, which after four days of incubat…
author: Vidovic, Elvira
language: eng
keywords: info:eu-repo/classification/ddc/540, Chemie, Hydrogele, Synthese, Bioabbaubar, Polyvinylalkohol, Polyester, hydrogel, synthesis, biodegradable, poly(vinyl alcohol)
date published: 2006
date modified: 2026-07-30T19:43:10Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University