{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:61378"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:61378","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Pharmacologically induced motor patterns in the suboesophageal ganglion of the locust","abstract":"Pharmacologically-induced motor patterns were studied in the locust suboesophageal ganglion. This model system comprises a complex pattern-generating network extending over several neuromeres. Strict coordination of motor patterns of different neuromeres is typical for mouthpart motor patterns making them a uniquely true in vitro model of complex behaviour. Spectral analysis of time series was used as a powerful tool for the evaluation of long time series for the first time in the analysis of pattern generation. It was shown that similar but not identical motor patterns are induced in the same system upon induction with pilocarpine and IBMX. Most prominent are the higher regularity and frequency of the motor pattern induced with IBMX. The new pharmacological tool allowed a study of the synaptic input to motoneurones and neurosecretory cells. This analysis showed that the input to efferent neurones is more complex than the spiking pattern recorded from them. Following hints given by the nature of the drugs known to induce motor patterns, questions on the transmitters involved in pattern generation were addressed. It was shown for the first time that the NO/cGMP signalling pathway is involved in mandibular pattern generation. The NO/cGMP pathway appears to act independently from the muscarinic pathway. Both sources and targets of NO were detected in histological preparations.","abstract_html":"Pharmacologically-induced motor patterns were studied in the locust suboesophageal ganglion. This model system comprises a complex pattern-generating network extending over several neuromeres. Strict coordination of motor patterns of different neuromeres is typical for mouthpart motor patterns making them a uniquely true in vitro model of complex behaviour. Spectral analysis of time series was used as a powerful tool for the evaluation of long time series for the first time in the analysis of pattern generation. It was shown that similar but not identical motor patterns are induced in the same system upon induction with pilocarpine and IBMX. Most prominent are the higher regularity and frequency of the motor pattern induced with IBMX. The new pharmacological tool allowed a study of the synaptic input to motoneurones and neurosecretory cells. This analysis showed that the input to efferent neurones is more complex than the spiking pattern recorded from them. Following hints given by the nature of the drugs known to induce motor patterns, questions on the transmitters involved in pattern generation were addressed. It was shown for the first time that the NO/cGMP signalling pathway is involved in mandibular pattern generation. The NO/cGMP pathway appears to act independently from the muscarinic pathway. 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This model system comprises a complex pattern-generating network extending over several neuromeres. Strict coordination of motor patterns of different neuromeres is typical for mouthpart motor patterns making them a uniquely true in vitro model of complex behaviour. Spectral analysis of time series was used as a powerful tool for the evaluation of long time series for the first time in the analysis of pattern generation. It was shown that similar but not identical motor patterns are induced in the same system upon induction with pilocarpine and IBMX. Most prominent are the higher regularity and frequency of the motor pattern induced with IBMX. The new pharmacological tool allowed a study of the synaptic input to motoneurones and neurosecretory cells. This analysis showed that the input to efferent neurones is more complex than the spiking pattern recorded from them. 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This model system comprises a complex pattern-generating network extending over several neuromeres. Strict coordination of motor patterns of different neuromeres is typical for mouthpart motor patterns making them a uniquely true in vitro model of complex behaviour. Spectral analysis of time series was used as a powerful tool for the evaluation of long time series for the first time in the analysis of pattern generation. It was shown that similar but not identical motor patterns are induced in the same system upon induction with pilocarpine and IBMX. Most prominent are the higher regularity and frequency of the motor pattern induced with IBMX. The new pharmacological tool allowed a study of the synaptic input to motoneurones and neurosecretory cells. This analysis showed that the input to efferent neurones is more complex than the spiking pattern recorded from them. 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