Asymmetrische Synthese funktionalisierter Homoallyl- und Homopropargylalkohole mittels der Sulfoximin-Route
type: CreativeWork
description: This dissertation describes new methods of asymmetric synthesis of diastereomeric and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. Via Nickel-catalysed cross-coupling reactions (homogenoes and heterogenoes Catalysis) of the homoallylic alcohols additional allylic silane- and allylic alcohol- groups were generated. Intramolecular cyclisation of the chiral allylic silanes with acetals yielded optically pure tetrasubstituted tetrahydrofurans.
abstract: This dissertation describes new methods of asymmetric synthesis of diastereomeric and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. Via Nickel-catalysed cross-coupling reactions (homogenoes and heterogenoes Catalysis) of the homoallylic alcohols additional allylic silane- and allylic alcohol- groups were generated. Intramolecular cyclisation of the chiral allylic silanes with acetals yielded optically pure tetrasubstituted tetrahydrofurans.
author: Woo, Chang-Wan
language: ger
keywords: info:eu-repo/classification/ddc/540, Chemie, Homoallyl-Verbindungen, Allylalkoholderivate, Asymmetrische Synthese, Sulfoximide, Allylgruppe, Hydroxyalkylierung, Propinolderivate, Funktione
date published: 2000
date modified: 2026-07-30T19:42:48Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University