Modifizierung von Glas- und Titanoberflächen zur Verbesserung der Biokompatibilität
type: CreativeWork
description: The goal of this study was the improvement of the biocompatibility of glass and titanium by surface modification. In biomaterial science glass is applied, for example, in biomedical sensors or optical waveguides. The functionality of these medical devices may be reduced by unspecific protein adsorption and uncontrolled cell adhesion. For this reason, the interaction of glass surfaces with biological fluids and tissue should be minimised. Titanium is often used for long term implants in orthopaedy or odontology. For these applications a strong interaction of the biomaterial surface with the surrounding tissue is necessary. Hence, the modification of the titanium surface aimed at the formation of a strong interfacial bond between implant and bone tissue. In the first part of this work the minimisation of protein adsorption and cell adhesion on glass surfaces was achieved by immobilisation of methoxylated poly(ethylene glycol) (M-PEG) and carboxymethylated dextran (CMD). These hydrophilic polymers were coupled onto glass surfaces, which were functionalised by silanisation with 3-aminopropyltriethoxysilane (APTES) and by dipcoating with poly(ethylene imine) (PEI) respectively. Furthermore a silane coupling agent (M-PEG-Silane) was prepared, which contains the M-PEG chain und facilitates a single step reaction. The protein resistant properties of the modified glass surfaces were investigated by adsorption of radiolabelled proteins, enzyme linked immunosorbent assay (ELISA) and matrix assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF-MS). Immobilisation of M-PEG and CMD significantly reduced protein adsorption, compared to unmodified glass surfaces. The strongest protein resistant surfaces were those modified with PEI/M-PEG and M-PEG-Silane respectively. Coupling of the hydrophilic polymers also resulted in a strong reduction of cell adhesion. According to the results of the protein adsorption studies surfaces modified with PEI/M-PEG and M-P…
abstract: The goal of this study was the improvement of the biocompatibility of glass and titanium by surface modification. In biomaterial science glass is applied, for example, in biomedical sensors or optical waveguides. The functionality of these medical devices may be reduced by unspecific protein adsorption and uncontrolled cell adhesion. For this reason, the interaction of glass surfaces with biological fluids and tissue should be minimised. Titanium is often used for long term implants in orthopaedy or odontology. For these applications a strong interaction of the biomaterial surface with the surrounding tissue is necessary. Hence, the modification of the titanium surface aimed at the formation of a strong interfacial bond between implant and bone tissue. In the first part of this work the minimisation of protein adsorption and cell adhesion on glass surfaces was achieved by immobilisation of methoxylated poly(ethylene glycol) (M-PEG) and carboxymethylated dextran (CMD). These hydrophilic polymers were coupled onto glass surfaces, which were functionalised by silanisation with 3-aminopropyltriethoxysilane (APTES) and by dipcoating with poly(ethylene imine) (PEI) respectively. Furthermore a silane coupling agent (M-PEG-Silane) was prepared, which contains the M-PEG chain und facilitates a single step reaction. The protein resistant properties of the modified glass surfaces were investigated by adsorption of radiolabelled proteins, enzyme linked immunosorbent assay (ELISA) and matrix assisted laser desorption/ionisation time of flight mass spectrometry (MALDI-TOF-MS). Immobilisation of M-PEG and CMD significantly reduced protein adsorption, compared to unmodified glass surfaces. The strongest protein resistant surfaces were those modified with PEI/M-PEG and M-PEG-Silane respectively. Coupling of the hydrophilic polymers also resulted in a strong reduction of cell adhesion. According to the results of the protein adsorption studies surfaces modified with PEI/M-PEG and M-P…
author: Böing, Jürgen
language: ger
keywords: info:eu-repo/classification/ddc/540, Chemie, Biokompatibilität, Glas, Titan, Oberflächenmodifizierung
date published: 2003
date modified: 2026-07-30T19:42:48Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University