Die Einmaldosierung von Aminoglykosiden bei unterschiedlicher Nierenfunktion in der Intensivmedizin
type: CreativeWork
description: The empirical dosages of the aminoglycosides Tobramycin and Amikazin are tested retrospectively using a one-dosage application system on a collective of critically ill patients. This study is carried out in order to test whether the dosages of said aminoglycosides administered empirically result in changes to the renal clearance on the one hand. On the other hand the aim of the test is to ascertain whether the recommended therapeutic levels are reached or even exceeded. This study is a retrospective analysis of the data of 47 patients taken from a collective of 1106 patients based on a time frame of 17 month. In over 85 per cent of all cases a renal clearance deterioration can be excluded while administering aminoglycosides. In the collective given Tobramycin 86 per cent of all cases display no renal clearance deterioration during therapy. The results yielded for the group of patients given Amikazin show that 2 out of 5 patients suffer a renal clearance reduction. Considering the data of all patients one notices that 17 per cent of all cases display a – usually low – clearance reduction. Examining the peak and trough dosage levels reveals that the medication levels advocated in the appropriate literature as effective are not always reached. In 50 per cent of all cases belonging to the Tobramycin group a sufficiently peak dosage can be reached 1 hour after application of the drug. All cases in the Amikazin group reach an acceptable level of effectiveness. The group using Tobramycin exceeds the highest level of the standardised trough dosage in 17 per cent of all cases. As opposed to that it cannot be shown that the Amikazin group exceeds the peak level at all. Using the collective tested here it has not been possible to proof a correlation between clearance reductions and elevated peak or – more importantly – trough levels. It becomes obvious that when looking at the peak and trough levels the empirical dosage given to critically ill patients tends to be slightly und…
abstract: The empirical dosages of the aminoglycosides Tobramycin and Amikazin are tested retrospectively using a one-dosage application system on a collective of critically ill patients. This study is carried out in order to test whether the dosages of said aminoglycosides administered empirically result in changes to the renal clearance on the one hand. On the other hand the aim of the test is to ascertain whether the recommended therapeutic levels are reached or even exceeded. This study is a retrospective analysis of the data of 47 patients taken from a collective of 1106 patients based on a time frame of 17 month. In over 85 per cent of all cases a renal clearance deterioration can be excluded while administering aminoglycosides. In the collective given Tobramycin 86 per cent of all cases display no renal clearance deterioration during therapy. The results yielded for the group of patients given Amikazin show that 2 out of 5 patients suffer a renal clearance reduction. Considering the data of all patients one notices that 17 per cent of all cases display a – usually low – clearance reduction. Examining the peak and trough dosage levels reveals that the medication levels advocated in the appropriate literature as effective are not always reached. In 50 per cent of all cases belonging to the Tobramycin group a sufficiently peak dosage can be reached 1 hour after application of the drug. All cases in the Amikazin group reach an acceptable level of effectiveness. The group using Tobramycin exceeds the highest level of the standardised trough dosage in 17 per cent of all cases. As opposed to that it cannot be shown that the Amikazin group exceeds the peak level at all. Using the collective tested here it has not been possible to proof a correlation between clearance reductions and elevated peak or – more importantly – trough levels. It becomes obvious that when looking at the peak and trough levels the empirical dosage given to critically ill patients tends to be slightly und…
author: Woltz, Christiane Elisabeth
language: ger
keywords: info:eu-repo/classification/ddc/610, Medizin, Aminoglykoside, Tobramycin, Amikazin, Niereninsuffizienz, Einmaldosierung, renale Clearance
date published: 2004
date modified: 2026-07-30T19:42:39Z
provider: RWTH Aachen University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Publikationsserver der RWTH Aachen University