{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:59368"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:59368","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Untersuchungen zur Verbesserung der Kompatibilität und der Adhäsion zwischen dem künstlichen Epithel und der Hornhaut mittels eines Dentinhaftvermittlers","abstract":"After severe chemical burns, the treatment of the exposed corneal stroma is generally started with the adhesion of a contact lens. The Histoacryl adhesive used during the surgery often causes unwanted side effects. Vascularisation of the cornea, leukocyte invasion and mechanical irritations and often a premature ablation of the contact lens are well-known side effects. The toxicity of the cyanoacrylate leads to histological alterations. A control of the ocular fundus, though important, can often not be realised as the blue adhesive disperses during the surgery. The most severe complication, however, is the disability of the epithelium to regenerate after the contact lens has been removed. Keratoplastic, which is difficult due to the neutralised immunologic status of the cornea, or a renewed adhesion are the only possible treatments left. Facing the complications, the objective of this study was to find a possible alternative to the Histoacryl adhesive. In the following, 24 corneas were examined after an incubation of two weeks. After the surfaces had been pre-treated with phosphoric acid, the corneas of group A were treated with Excite and the corneas of group B were additionally treated with a fine hybrid composite. The contact lenses were each time pre-treated with Heliobond. The new Excite system established a bridge between the hydrophilic cornea and the hydrophobic contact lens/Heliobond. The histological results indicate that Excite has a sufficient biocompatibility. The results of group A in particular showed a good compatibility of the adhesive. The cell picture was homogenous, significant changes were not observed. The in vitro adhesion is sufficient as well. Group B, however, showed a swelling of the cornea. The subepithelial stroma and the Bowman's layer were affected in particular. However, the adhesion was considerably better, so the system deserves a clinical relevance as well. Unfortunately, the adhesion became thicker, so the patient might have a foreign body feeling. The outstanding feature of Excite is, however, that it can be used at different humidity levels of the dentin. Excite is less sensitive to humidity. Due to the high water content in the cornea, this is of utmost importance for the realised tests. Furthermore, the handling is easier due to better application systems, and due to the transparency of the material even the inside of the eye can be controlled. A waterproof suture at the edge and an apposition to the conjunctiva might also be proved clinically. A cornea reepithelisation would also be decisive for the success of the system. The presented results have shown that the adhesion between the artificial epithelium and the cornea by means of a dental adhesive might be an alternative to the Histoacryl adhesive. As the summary, however, does only describe morphologic observations, the limits of the systems have to be tested in clinical studies. The mechanic of eye-lids and tear fluid should be considered in particular. Proteolytic enzymes might interfere with the system as well. Clinical experiences will have to show if the complications occurring during the adhesion with the tissue glue Histoacryl can be prevented with Excite.","abstract_html":"After severe chemical burns, the treatment of the exposed corneal stroma is generally started with the adhesion of a contact lens. The Histoacryl adhesive used during the surgery often causes unwanted side effects. Vascularisation of the cornea, leukocyte invasion and mechanical irritations and often a premature ablation of the contact lens are well-known side effects. The toxicity of the cyanoacrylate leads to histological alterations. A control of the ocular fundus, though important, can often not be realised as the blue adhesive disperses during the surgery. The most severe complication, however, is the disability of the epithelium to regenerate after the contact lens has been removed. Keratoplastic, which is difficult due to the neutralised immunologic status of the cornea, or a renewed adhesion are the only possible treatments left. Facing the complications, the objective of this study was to find a possible alternative to the Histoacryl adhesive. In the following, 24 corneas were examined after an incubation of two weeks. After the surfaces had been pre-treated with phosphoric acid, the corneas of group A were treated with Excite and the corneas of group B were additionally treated with a fine hybrid composite. The contact lenses were each time pre-treated with Heliobond. The new Excite system established a bridge between the hydrophilic cornea and the hydrophobic contact lens/Heliobond. The histological results indicate that Excite has a sufficient biocompatibility. The results of group A in particular showed a good compatibility of the adhesive. The cell picture was homogenous, significant changes were not observed. The in vitro adhesion is sufficient as well. Group B, however, showed a swelling of the cornea. The subepithelial stroma and the Bowman's layer were affected in particular. However, the adhesion was considerably better, so the system deserves a clinical relevance as well. Unfortunately, the adhesion became thicker, so the patient might have a foreign body feeling. The outstanding feature of Excite is, however, that it can be used at different humidity levels of the dentin. Excite is less sensitive to humidity. Due to the high water content in the cornea, this is of utmost importance for the realised tests. Furthermore, the handling is easier due to better application systems, and due to the transparency of the material even the inside of the eye can be controlled. A waterproof suture at the edge and an apposition to the conjunctiva might also be proved clinically. A cornea reepithelisation would also be decisive for the success of the system. The presented results have shown that the adhesion between the artificial epithelium and the cornea by means of a dental adhesive might be an alternative to the Histoacryl adhesive. As the summary, however, does only describe morphologic observations, the limits of the systems have to be tested in clinical studies. The mechanic of eye-lids and tear fluid should be considered in particular. Proteolytic enzymes might interfere with the system as well. Clinical experiences will have to show if the complications occurring during the adhesion with the tissue glue Histoacryl can be prevented with Excite.","abstract_has_math":false,"creators":["Poprawa, Alexandra"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Redbrake, Claudia"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004","date_published":"2004","updated_at":"2026-07-30T19:42:39Z","subjects":["info:eu-repo/classification/ddc/610","Medizin"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121158%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121158%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121158%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/59368","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Redbrake, Claudia"]},{"key":"dc:creator","label":"Author","values":["Poprawa, Alexandra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2004"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-7513"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Medizin"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/59368","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121158%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["After severe chemical burns, the treatment of the exposed corneal stroma is generally started with the adhesion of a contact lens. The Histoacryl adhesive used during the surgery often causes unwanted side effects. Vascularisation of the cornea, leukocyte invasion and mechanical irritations and often a premature ablation of the contact lens are well-known side effects. The toxicity of the cyanoacrylate leads to histological alterations. A control of the ocular fundus, though important, can often not be realised as the blue adhesive disperses during the surgery. The most severe complication, however, is the disability of the epithelium to regenerate after the contact lens has been removed. Keratoplastic, which is difficult due to the neutralised immunologic status of the cornea, or a renewed adhesion are the only possible treatments left. Facing the complications, the objective of this study was to find a possible alternative to the Histoacryl adhesive. In the following, 24 corneas were examined after an incubation of two weeks. After the surfaces had been pre-treated with phosphoric acid, the corneas of group A were treated with Excite and the corneas of group B were additionally treated with a fine hybrid composite. The contact lenses were each time pre-treated with Heliobond. The new Excite system established a bridge between the hydrophilic cornea and the hydrophobic contact lens/Heliobond. The histological results indicate that Excite has a sufficient biocompatibility. The results of group A in particular showed a good compatibility of the adhesive. The cell picture was homogenous, significant changes were not observed. The in vitro adhesion is sufficient as well. Group B, however, showed a swelling of the cornea. The subepithelial stroma and the Bowman's layer were affected in particular. However, the adhesion was considerably better, so the system deserves a clinical relevance as well. Unfortunately, the adhesion became thicker, so the patient might have a foreign body feeling. The outstanding feature of Excite is, however, that it can be used at different humidity levels of the dentin. Excite is less sensitive to humidity. Due to the high water content in the cornea, this is of utmost importance for the realised tests. Furthermore, the handling is easier due to better application systems, and due to the transparency of the material even the inside of the eye can be controlled. A waterproof suture at the edge and an apposition to the conjunctiva might also be proved clinically. A cornea reepithelisation would also be decisive for the success of the system. The presented results have shown that the adhesion between the artificial epithelium and the cornea by means of a dental adhesive might be an alternative to the Histoacryl adhesive. As the summary, however, does only describe morphologic observations, the limits of the systems have to be tested in clinical studies. The mechanic of eye-lids and tear fluid should be considered in particular. Proteolytic enzymes might interfere with the system as well. Clinical experiences will have to show if the complications occurring during the adhesion with the tissue glue Histoacryl can be prevented with Excite."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 61 S. : Ill., graph. Darst. (2004). = Aachen, Techn. Hochsch., Diss., 2004"]},{"key":"dc:title","label":"Title","values":["Untersuchungen zur Verbesserung der Kompatibilität und der Adhäsion zwischen dem künstlichen Epithel und der Hornhaut mittels eines Dentinhaftvermittlers"]}]}],"canonical_facts":{"dc:contributor":["Redbrake, Claudia"],"dc:coverage":["DE"],"dc:creator":["Poprawa, Alexandra"],"dc:date":["2004"],"dc:description":["After severe chemical burns, the treatment of the exposed corneal stroma is generally started with the adhesion of a contact lens. The Histoacryl adhesive used during the surgery often causes unwanted side effects. Vascularisation of the cornea, leukocyte invasion and mechanical irritations and often a premature ablation of the contact lens are well-known side effects. The toxicity of the cyanoacrylate leads to histological alterations. A control of the ocular fundus, though important, can often not be realised as the blue adhesive disperses during the surgery. The most severe complication, however, is the disability of the epithelium to regenerate after the contact lens has been removed. Keratoplastic, which is difficult due to the neutralised immunologic status of the cornea, or a renewed adhesion are the only possible treatments left. Facing the complications, the objective of this study was to find a possible alternative to the Histoacryl adhesive. In the following, 24 corneas were examined after an incubation of two weeks. After the surfaces had been pre-treated with phosphoric acid, the corneas of group A were treated with Excite and the corneas of group B were additionally treated with a fine hybrid composite. The contact lenses were each time pre-treated with Heliobond. The new Excite system established a bridge between the hydrophilic cornea and the hydrophobic contact lens/Heliobond. The histological results indicate that Excite has a sufficient biocompatibility. The results of group A in particular showed a good compatibility of the adhesive. The cell picture was homogenous, significant changes were not observed. The in vitro adhesion is sufficient as well. Group B, however, showed a swelling of the cornea. The subepithelial stroma and the Bowman's layer were affected in particular. However, the adhesion was considerably better, so the system deserves a clinical relevance as well. Unfortunately, the adhesion became thicker, so the patient might have a foreign body feeling. The outstanding feature of Excite is, however, that it can be used at different humidity levels of the dentin. Excite is less sensitive to humidity. Due to the high water content in the cornea, this is of utmost importance for the realised tests. Furthermore, the handling is easier due to better application systems, and due to the transparency of the material even the inside of the eye can be controlled. A waterproof suture at the edge and an apposition to the conjunctiva might also be proved clinically. A cornea reepithelisation would also be decisive for the success of the system. The presented results have shown that the adhesion between the artificial epithelium and the cornea by means of a dental adhesive might be an alternative to the Histoacryl adhesive. As the summary, however, does only describe morphologic observations, the limits of the systems have to be tested in clinical studies. The mechanic of eye-lids and tear fluid should be considered in particular. Proteolytic enzymes might interfere with the system as well. Clinical experiences will have to show if the complications occurring during the adhesion with the tissue glue Histoacryl can be prevented with Excite."],"dc:identifier":["https://publications.rwth-aachen.de/record/59368","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-121158%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-7513"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 61 S. : Ill., graph. Darst. (2004). = Aachen, Techn. Hochsch., Diss., 2004"],"dc:subject":["info:eu-repo/classification/ddc/610","Medizin"],"dc:title":["Untersuchungen zur Verbesserung der Kompatibilität und der Adhäsion zwischen dem künstlichen Epithel und der Hornhaut mittels eines Dentinhaftvermittlers"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:42:39Z"}