{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:57174"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:57174","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Pathophysiologie des Morbus Sudeck : eine experimentelle Studie an Kaninchen und klinische Fallbeispiele","abstract":"Introduction. Reflex sympathetic dystrophy (RSD) is an unpredictable and difficult to treat syndrome in current hand surgery. It remains a very controversial subject even 100 years after its primary description by P. Sudeck in 1902. Since then, a lot of etiologic hypotheses have been discussed. Some allowed specific therapeutic options: sympathetic blocks, analgesic drugs, specific physiotherapy and neurovascular release with additional upper thoracic sympathectomy (Wilhelm 1987-1998). Material and methods: To assess the influence of limb venous run-off restriction with or without nerve trunc constriction and a trauma on the development of RSD – like scintigraphic changes, 12 female rabbits were operated on and examined by standard 3 stage Technetium scintigraphy and clinical follow – up. Further tools were blood parameter and histology. Forelimbs were not suitable; therefore operations on group 1 with isolated femoral venous outflow restrictions and on group 2 with additional sciatic trunc constrictions were performed and the animals followed for 6 months. Control scintigraphy was performed after 3 and 6 weeks. In 7 out of 12 animals, we applied a standardised distal limb compression without skin damage, either by a metal piston (5 to 10 bar, for 3 seconds) or by a vice (shrinkage from 2 to 0.7 cm). Parallel clinical cases were analysed refer to reasons of RSD, therapy and results. Results: The signs of acute RSD with increased inflow, blood pool and bone uptake could be found in the rabbits 3 and 12 weeks postoperatively. The chronic RSD with hyperperfusion and decreased bone uptake were shown 3 and 9 months after surgery. Conclusions: Although the rabbits did not develop clinical RSD, the scintigraphic findings suggest that this model could be refined for better understanding of the neuro-vascular pathophysiology of RSD. Also the analysis of the clinical cases supported this theory.","abstract_html":"Introduction. Reflex sympathetic dystrophy (RSD) is an unpredictable and difficult to treat syndrome in current hand surgery. It remains a very controversial subject even 100 years after its primary description by P. Sudeck in 1902. Since then, a lot of etiologic hypotheses have been discussed. Some allowed specific therapeutic options: sympathetic blocks, analgesic drugs, specific physiotherapy and neurovascular release with additional upper thoracic sympathectomy (Wilhelm 1987-1998). Material and methods: To assess the influence of limb venous run-off restriction with or without nerve trunc constriction and a trauma on the development of RSD – like scintigraphic changes, 12 female rabbits were operated on and examined by standard 3 stage Technetium scintigraphy and clinical follow – up. Further tools were blood parameter and histology. Forelimbs were not suitable; therefore operations on group 1 with isolated femoral venous outflow restrictions and on group 2 with additional sciatic trunc constrictions were performed and the animals followed for 6 months. Control scintigraphy was performed after 3 and 6 weeks. In 7 out of 12 animals, we applied a standardised distal limb compression without skin damage, either by a metal piston (5 to 10 bar, for 3 seconds) or by a vice (shrinkage from 2 to 0.7 cm). Parallel clinical cases were analysed refer to reasons of RSD, therapy and results. Results: The signs of acute RSD with increased inflow, blood pool and bone uptake could be found in the rabbits 3 and 12 weeks postoperatively. The chronic RSD with hyperperfusion and decreased bone uptake were shown 3 and 9 months after surgery. Conclusions: Although the rabbits did not develop clinical RSD, the scintigraphic findings suggest that this model could be refined for better understanding of the neuro-vascular pathophysiology of RSD. Also the analysis of the clinical cases supported this theory.","abstract_has_math":false,"creators":["Markowicz, Marta"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Pallua, Norbert"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2002,"date_issued":"2002","date_published":"2002","updated_at":"2026-07-30T19:42:09Z","subjects":["info:eu-repo/classification/ddc/610","Medizin","Morbus Sudeck","Sympathische Reflexdystrophie","Drei-Phasen-Szintigraphie"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119239%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119239%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119239%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/57174","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pallua, Norbert"]},{"key":"dc:creator","label":"Author","values":["Markowicz, Marta"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2002"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-4382"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Medizin","Morbus Sudeck","Sympathische Reflexdystrophie","Drei-Phasen-Szintigraphie"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/57174","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119239%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Introduction. Reflex sympathetic dystrophy (RSD) is an unpredictable and difficult to treat syndrome in current hand surgery. It remains a very controversial subject even 100 years after its primary description by P. Sudeck in 1902. Since then, a lot of etiologic hypotheses have been discussed. Some allowed specific therapeutic options: sympathetic blocks, analgesic drugs, specific physiotherapy and neurovascular release with additional upper thoracic sympathectomy (Wilhelm 1987-1998). Material and methods: To assess the influence of limb venous run-off restriction with or without nerve trunc constriction and a trauma on the development of RSD – like scintigraphic changes, 12 female rabbits were operated on and examined by standard 3 stage Technetium scintigraphy and clinical follow – up. Further tools were blood parameter and histology. Forelimbs were not suitable; therefore operations on group 1 with isolated femoral venous outflow restrictions and on group 2 with additional sciatic trunc constrictions were performed and the animals followed for 6 months. Control scintigraphy was performed after 3 and 6 weeks. In 7 out of 12 animals, we applied a standardised distal limb compression without skin damage, either by a metal piston (5 to 10 bar, for 3 seconds) or by a vice (shrinkage from 2 to 0.7 cm). Parallel clinical cases were analysed refer to reasons of RSD, therapy and results. Results: The signs of acute RSD with increased inflow, blood pool and bone uptake could be found in the rabbits 3 and 12 weeks postoperatively. The chronic RSD with hyperperfusion and decreased bone uptake were shown 3 and 9 months after surgery. Conclusions: Although the rabbits did not develop clinical RSD, the scintigraphic findings suggest that this model could be refined for better understanding of the neuro-vascular pathophysiology of RSD. Also the analysis of the clinical cases supported this theory."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 69 S. : Ill., graph. Darst. (2002). = Aachen, Techn. Hochsch., Diss., 2002"]},{"key":"dc:title","label":"Title","values":["Pathophysiologie des Morbus Sudeck : eine experimentelle Studie an Kaninchen und klinische Fallbeispiele"]}]}],"canonical_facts":{"dc:contributor":["Pallua, Norbert"],"dc:coverage":["DE"],"dc:creator":["Markowicz, Marta"],"dc:date":["2002"],"dc:description":["Introduction. Reflex sympathetic dystrophy (RSD) is an unpredictable and difficult to treat syndrome in current hand surgery. It remains a very controversial subject even 100 years after its primary description by P. Sudeck in 1902. Since then, a lot of etiologic hypotheses have been discussed. Some allowed specific therapeutic options: sympathetic blocks, analgesic drugs, specific physiotherapy and neurovascular release with additional upper thoracic sympathectomy (Wilhelm 1987-1998). Material and methods: To assess the influence of limb venous run-off restriction with or without nerve trunc constriction and a trauma on the development of RSD – like scintigraphic changes, 12 female rabbits were operated on and examined by standard 3 stage Technetium scintigraphy and clinical follow – up. Further tools were blood parameter and histology. Forelimbs were not suitable; therefore operations on group 1 with isolated femoral venous outflow restrictions and on group 2 with additional sciatic trunc constrictions were performed and the animals followed for 6 months. Control scintigraphy was performed after 3 and 6 weeks. In 7 out of 12 animals, we applied a standardised distal limb compression without skin damage, either by a metal piston (5 to 10 bar, for 3 seconds) or by a vice (shrinkage from 2 to 0.7 cm). Parallel clinical cases were analysed refer to reasons of RSD, therapy and results. Results: The signs of acute RSD with increased inflow, blood pool and bone uptake could be found in the rabbits 3 and 12 weeks postoperatively. The chronic RSD with hyperperfusion and decreased bone uptake were shown 3 and 9 months after surgery. Conclusions: Although the rabbits did not develop clinical RSD, the scintigraphic findings suggest that this model could be refined for better understanding of the neuro-vascular pathophysiology of RSD. Also the analysis of the clinical cases supported this theory."],"dc:identifier":["https://publications.rwth-aachen.de/record/57174","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-119239%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-4382"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 69 S. : Ill., graph. Darst. (2002). = Aachen, Techn. Hochsch., Diss., 2002"],"dc:subject":["info:eu-repo/classification/ddc/610","Medizin","Morbus Sudeck","Sympathische Reflexdystrophie","Drei-Phasen-Szintigraphie"],"dc:title":["Pathophysiologie des Morbus Sudeck : eine experimentelle Studie an Kaninchen und klinische Fallbeispiele"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:42:09Z"}