{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:52723"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:52723","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Metallacyclopeptide","abstract":"Therefore, linear peptides with two metal binding sites were obtained by solid phase synthesis. Upon coordination of these ligands to a metal centre a metalla-cyclopeptide will be formed. The choosen peptide sequences are found in naturally occuring proteins or cyclopeptides, which bioactivities depends on the sequence of the amino acids as well as it´s loop type structure. Pd(II) and Mo(VI)O2 are used as metal centres to obtain different conformations at the peptide backbone in the metalla-cyclopeptides. This requires the use of pyridine and catechol as metal binding sites. Following to this concept, a series of Mo(VI)O2-metalla-cyclopeptides could be obtained in a highly stereoselektiv manner. These metalla-cyclopeptides represents analogs of the RGD front in Echistatin, which binds to the integrins, of the estrogen-like cyclopeptides Segetalin A and B and finally of the somatostatin-like cyclopeptide Urotensin II, which posses vasoconstrictor activity. Furthermore, pentapeptide-bridged macrocyclic Mo(VI)O2-complexes were synthesized, that offers more knowledge in the stabilisation of peptide-a-helical structure.","abstract_html":"Therefore, linear peptides with two metal binding sites were obtained by solid phase synthesis. Upon coordination of these ligands to a metal centre a metalla-cyclopeptide will be formed. The choosen peptide sequences are found in naturally occuring proteins or cyclopeptides, which bioactivities depends on the sequence of the amino acids as well as it´s loop type structure. Pd(II) and Mo(VI)O2 are used as metal centres to obtain different conformations at the peptide backbone in the metalla-cyclopeptides. This requires the use of pyridine and catechol as metal binding sites. Following to this concept, a series of Mo(VI)O2-metalla-cyclopeptides could be obtained in a highly stereoselektiv manner. These metalla-cyclopeptides represents analogs of the RGD front in Echistatin, which binds to the integrins, of the estrogen-like cyclopeptides Segetalin A and B and finally of the somatostatin-like cyclopeptide Urotensin II, which posses vasoconstrictor activity. Furthermore, pentapeptide-bridged macrocyclic Mo(VI)O2-complexes were synthesized, that offers more knowledge in the stabilisation of peptide-a-helical structure.","abstract_has_math":false,"creators":["Stortz, Patrick"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Albrecht, Markus"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2004,"date_issued":"2004","date_published":"2004","updated_at":"2026-07-30T19:41:00Z","subjects":["info:eu-repo/classification/ddc/540","Übergangsmetallkomplexe","Cyclopeptide","Makrocyclische Verbindungen","Chemie","Metallkoordination","Festphasensynthese"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114925%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114925%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114925%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/52723","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A52723","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Albrecht, Markus"]},{"key":"dc:creator","label":"Author","values":["Stortz, Patrick"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2004"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-10075"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/540","Übergangsmetallkomplexe","Cyclopeptide","Makrocyclische Verbindungen","Chemie","Metallkoordination","Festphasensynthese"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/52723","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114925%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Therefore, linear peptides with two metal binding sites were obtained by solid phase synthesis. 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Furthermore, pentapeptide-bridged macrocyclic Mo(VI)O2-complexes were synthesized, that offers more knowledge in the stabilisation of peptide-a-helical structure."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 160 S. (2004). = Aachen, Techn. Univ., Diss., 2004"]},{"key":"dc:title","label":"Title","values":["Metallacyclopeptide"]}]}],"canonical_facts":{"dc:contributor":["Albrecht, Markus"],"dc:coverage":["DE"],"dc:creator":["Stortz, Patrick"],"dc:date":["2004"],"dc:description":["Therefore, linear peptides with two metal binding sites were obtained by solid phase synthesis. Upon coordination of these ligands to a metal centre a metalla-cyclopeptide will be formed. The choosen peptide sequences are found in naturally occuring proteins or cyclopeptides, which bioactivities depends on the sequence of the amino acids as well as it´s loop type structure. 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Furthermore, pentapeptide-bridged macrocyclic Mo(VI)O2-complexes were synthesized, that offers more knowledge in the stabilisation of peptide-a-helical structure."],"dc:identifier":["https://publications.rwth-aachen.de/record/52723","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-114925%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-10075"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 160 S. (2004). = Aachen, Techn. Univ., Diss., 2004"],"dc:subject":["info:eu-repo/classification/ddc/540","Übergangsmetallkomplexe","Cyclopeptide","Makrocyclische Verbindungen","Chemie","Metallkoordination","Festphasensynthese"],"dc:title":["Metallacyclopeptide"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:41:00Z"}