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Due to the fact that the stereochemistry of the beta-amino alcohol moiety is important for biological activity and for chirality transfer, asymmetric synthesis of compounds containing beta-amino alcohol functionality has drawn considerable attention. This thesis describes enantioselective synthesis of cyclic beta-amino alcohols starting from ethoxycarbonyl vinyl sulfoximines, which are prepared from cyclic bis(allylsulfoximine)titanium complexes and N-tert-butylsulfonyl alpha-imino ester. The application of sulfoximine substituted bicyclic 1,2-amino alcohol in the synthesis of potential aggrecanase inhibitor is described.","abstract_html":"The beta-amino alcohol moiety is a common structural component in a wide variety of natural occurring compounds, synthetic pharmacologically important molecules, ligands and chiral auxiliaries for asymmetric synthesis. Due to the fact that the stereochemistry of the beta-amino alcohol moiety is important for biological activity and for chirality transfer, asymmetric synthesis of compounds containing beta-amino alcohol functionality has drawn considerable attention. This thesis describes enantioselective synthesis of cyclic beta-amino alcohols starting from ethoxycarbonyl vinyl sulfoximines, which are prepared from cyclic bis(allylsulfoximine)titanium complexes and N-tert-butylsulfonyl alpha-imino ester. 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Due to the fact that the stereochemistry of the beta-amino alcohol moiety is important for biological activity and for chirality transfer, asymmetric synthesis of compounds containing beta-amino alcohol functionality has drawn considerable attention. This thesis describes enantioselective synthesis of cyclic beta-amino alcohols starting from ethoxycarbonyl vinyl sulfoximines, which are prepared from cyclic bis(allylsulfoximine)titanium complexes and N-tert-butylsulfonyl alpha-imino ester. The application of sulfoximine substituted bicyclic 1,2-amino alcohol in the synthesis of potential aggrecanase inhibitor is described."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 154 S. : graph. Darst. (2009). = Aachen, Techn. Hochsch., Diss., 2009"]},{"key":"dc:title","label":"Title","values":["Enantioselective synthesis of cyclic beta-amino alcohols via tandem hydroalumination-cyclization-reduction of ethoxycarbonyl vinyl sulfoximines and application to the synthesis of potential aggrecanase inhibitors"]}]}],"canonical_facts":{"dc:contributor":["Gais, Hans-Joachim"],"dc:coverage":["DE"],"dc:creator":["Acikalin, Serdar"],"dc:date":["2009"],"dc:description":["The beta-amino alcohol moiety is a common structural component in a wide variety of natural occurring compounds, synthetic pharmacologically important molecules, ligands and chiral auxiliaries for asymmetric synthesis. Due to the fact that the stereochemistry of the beta-amino alcohol moiety is important for biological activity and for chirality transfer, asymmetric synthesis of compounds containing beta-amino alcohol functionality has drawn considerable attention. 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