{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:51262"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:51262","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Rutheniumkatalysierte Hydratisierung von terminalen Alkinen und deren Einsatz in Synthesestrategien","abstract":"In the context of this work the ruthenium-catalyzed anti-Markovnikon-hydration of terminal alkynes was optimized. This covers the reaction conditions (catalyst loading, concentration, solvent/reaction media, equivalents of water, additives and exchange of the counterion) as well as the variation of the ruthenium complex via ligand exchange. The most aktivst catalyst was the [cyclopentadienylruthenium(II)(2-diphenylphosphino-6-(2,4,6-triphenylphenyl)pyridine)(triphenylphosphino)(acetonitrile)]hexafluorophosphate complex. Beside the optimization of the catalysis the ruthenium-catalyzed anti-Markovnikov-hydration was used in synthetic strategies to result aldols and poly-1,3-diols and also poly-1,4-diols. The poly-1,4-diols led via a sequential synthesis from simple base-chemicals to poly-1,4-diols with high structural complexity and natural related compounds. The hydration of propargyl alcohols to aldols, respectively 1,3-diols was more challenging in comparison to the hydration of 1,4-diols. But finally, it was possible to synthesize the massoialactone and a derivative of the family of the polyacetate secondary pyrons.","abstract_html":"In the context of this work the ruthenium-catalyzed anti-Markovnikon-hydration of terminal alkynes was optimized. This covers the reaction conditions (catalyst loading, concentration, solvent/reaction media, equivalents of water, additives and exchange of the counterion) as well as the variation of the ruthenium complex via ligand exchange. The most aktivst catalyst was the [cyclopentadienylruthenium(II)(2-diphenylphosphino-6-(2,4,6-triphenylphenyl)pyridine)(triphenylphosphino)(acetonitrile)]hexafluorophosphate complex. Beside the optimization of the catalysis the ruthenium-catalyzed anti-Markovnikov-hydration was used in synthetic strategies to result aldols and poly-1,3-diols and also poly-1,4-diols. The poly-1,4-diols led via a sequential synthesis from simple base-chemicals to poly-1,4-diols with high structural complexity and natural related compounds. The hydration of propargyl alcohols to aldols, respectively 1,3-diols was more challenging in comparison to the hydration of 1,4-diols. 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This covers the reaction conditions (catalyst loading, concentration, solvent/reaction media, equivalents of water, additives and exchange of the counterion) as well as the variation of the ruthenium complex via ligand exchange. The most aktivst catalyst was the [cyclopentadienylruthenium(II)(2-diphenylphosphino-6-(2,4,6-triphenylphenyl)pyridine)(triphenylphosphino)(acetonitrile)]hexafluorophosphate complex. Beside the optimization of the catalysis the ruthenium-catalyzed anti-Markovnikov-hydration was used in synthetic strategies to result aldols and poly-1,3-diols and also poly-1,4-diols. The poly-1,4-diols led via a sequential synthesis from simple base-chemicals to poly-1,4-diols with high structural complexity and natural related compounds. The hydration of propargyl alcohols to aldols, respectively 1,3-diols was more challenging in comparison to the hydration of 1,4-diols. But finally, it was possible to synthesize the massoialactone and a derivative of the family of the polyacetate secondary pyrons."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 138 S. (2009). = Aachen, Techn. Hochsch., Diss., 2009"]},{"key":"dc:title","label":"Title","values":["Rutheniumkatalysierte Hydratisierung von terminalen Alkinen und deren Einsatz in Synthesestrategien"]}]}],"canonical_facts":{"dc:contributor":["Hintermann, Lukas"],"dc:coverage":["DE"],"dc:creator":["Kribber, Thomas Clemens"],"dc:date":["2009"],"dc:description":["In the context of this work the ruthenium-catalyzed anti-Markovnikon-hydration of terminal alkynes was optimized. This covers the reaction conditions (catalyst loading, concentration, solvent/reaction media, equivalents of water, additives and exchange of the counterion) as well as the variation of the ruthenium complex via ligand exchange. 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