{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:51200"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:51200","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Die Ventilation mit biphasic positive airway pressure (BIPAP) im experimentellen akuten Lungenschaden : der Einfluß des transpulmonalen Drucks auf Gasaustausch und Hämodynamik","abstract":"OBJECTIVE: We investigated whether improvement in ventilation perfusion distribution during mechanical ventilation using biphasic positive airway pressure (BIPAP) with spontaneous breathing may be attributed to an effectively increased transpulmonary pressure (PTP) and can also be achieved by increasing PTP during controlled ventilation. DESIGN: In 12 pigs with saline lavage-induced lung injury we compared the effects of BIPAP to pressure-controlled ventilation with equal airway pressure (PCVAW) or equal transpulmonary pressure (PCVTP) on ventilation perfusion distribution assessed by the multiple inert gas elimination technique (MIGET).Measurements and results: Intrapulmonary shunt was 33±11% during BIPAP, 36±10% during PCVAW and 33±15% during PCVTP (p= n.s.). BIPAP resulted in higher PaO2 than PCVAW (188±83 versus 147±82 mmHg, p<0.05), but not than PCVTP (187±139 mmHg). Oxygen delivery was significantly higher during BIPAP (530±109 ml/min) versus 374±113 ml/min during PCVAW and 353±93 ml/min during PCVTP (p<0.005). Tidal volume with PCVTP increased to 11.9±2.3 ml/kg, compared to 8.5±0.8 with BIPAP and 7.6±1.4 with PCVAW (p<0.001) and cardiac output decreased to 3.5±0.6 l/min (BIPAP 4.9±0.8 and PCVAW 3.9±0.8, p<0.006). CONCLUSIONS: In experimental lung injury, BIPAP with preserved spontaneous breathing was effective in increasing regional PTP, since pressure-controlled ventilation with the same PTP resulted in similar gas exchange effects. However, PCVTP caused increased airway pressures and tidal volumes, whereby, with BIPAP, less depression of oxygen delivery and cardiac output were observed. BIPAP could be useful in maintaining pulmonary gas exchange and slightly improving oxygenation without interfering with circulation as strongly as PCV does.","abstract_html":"OBJECTIVE: We investigated whether improvement in ventilation perfusion distribution during mechanical ventilation using biphasic positive airway pressure (BIPAP) with spontaneous breathing may be attributed to an effectively increased transpulmonary pressure (PTP) and can also be achieved by increasing PTP during controlled ventilation. DESIGN: In 12 pigs with saline lavage-induced lung injury we compared the effects of BIPAP to pressure-controlled ventilation with equal airway pressure (PCVAW) or equal transpulmonary pressure (PCVTP) on ventilation perfusion distribution assessed by the multiple inert gas elimination technique (MIGET).Measurements and results: Intrapulmonary shunt was 33±11% during BIPAP, 36±10% during PCVAW and 33±15% during PCVTP (p= n.s.). BIPAP resulted in higher PaO2 than PCVAW (188±83 versus 147±82 mmHg, p&lt;0.05), but not than PCVTP (187±139 mmHg). Oxygen delivery was significantly higher during BIPAP (530±109 ml/min) versus 374±113 ml/min during PCVAW and 353±93 ml/min during PCVTP (p&lt;0.005). Tidal volume with PCVTP increased to 11.9±2.3 ml/kg, compared to 8.5±0.8 with BIPAP and 7.6±1.4 with PCVAW (p&lt;0.001) and cardiac output decreased to 3.5±0.6 l/min (BIPAP 4.9±0.8 and PCVAW 3.9±0.8, p&lt;0.006). CONCLUSIONS: In experimental lung injury, BIPAP with preserved spontaneous breathing was effective in increasing regional PTP, since pressure-controlled ventilation with the same PTP resulted in similar gas exchange effects. However, PCVTP caused increased airway pressures and tidal volumes, whereby, with BIPAP, less depression of oxygen delivery and cardiac output were observed. BIPAP could be useful in maintaining pulmonary gas exchange and slightly improving oxygenation without interfering with circulation as strongly as PCV does.","abstract_has_math":false,"creators":["Hatam, Nima"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Autschbach, Rüdiger"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-30T19:40:33Z","subjects":["info:eu-repo/classification/ddc/610","Lungenverletzung","Ventilation","Gasaustausch","Hämodynamik","Medizin","BIPAP","Transpulmonaler Druck","biphasic positive airway pressure"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113512%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113512%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113512%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/51200","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51200","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Autschbach, Rüdiger"]},{"key":"dc:creator","label":"Author","values":["Hatam, Nima"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2009"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-27238"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Lungenverletzung","Ventilation","Gasaustausch","Hämodynamik","Medizin","BIPAP","Transpulmonaler Druck","biphasic positive airway pressure"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/51200","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113512%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["OBJECTIVE: We investigated whether improvement in ventilation perfusion distribution during mechanical ventilation using biphasic positive airway pressure (BIPAP) with spontaneous breathing may be attributed to an effectively increased transpulmonary pressure (PTP) and can also be achieved by increasing PTP during controlled ventilation. DESIGN: In 12 pigs with saline lavage-induced lung injury we compared the effects of BIPAP to pressure-controlled ventilation with equal airway pressure (PCVAW) or equal transpulmonary pressure (PCVTP) on ventilation perfusion distribution assessed by the multiple inert gas elimination technique (MIGET).Measurements and results: Intrapulmonary shunt was 33±11% during BIPAP, 36±10% during PCVAW and 33±15% during PCVTP (p= n.s.). BIPAP resulted in higher PaO2 than PCVAW (188±83 versus 147±82 mmHg, p<0.05), but not than PCVTP (187±139 mmHg). Oxygen delivery was significantly higher during BIPAP (530±109 ml/min) versus 374±113 ml/min during PCVAW and 353±93 ml/min during PCVTP (p<0.005). Tidal volume with PCVTP increased to 11.9±2.3 ml/kg, compared to 8.5±0.8 with BIPAP and 7.6±1.4 with PCVAW (p<0.001) and cardiac output decreased to 3.5±0.6 l/min (BIPAP 4.9±0.8 and PCVAW 3.9±0.8, p<0.006). CONCLUSIONS: In experimental lung injury, BIPAP with preserved spontaneous breathing was effective in increasing regional PTP, since pressure-controlled ventilation with the same PTP resulted in similar gas exchange effects. However, PCVTP caused increased airway pressures and tidal volumes, whereby, with BIPAP, less depression of oxygen delivery and cardiac output were observed. BIPAP could be useful in maintaining pulmonary gas exchange and slightly improving oxygenation without interfering with circulation as strongly as PCV does."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 47 S. : graph. Darst. (2009). = Aachen, Techn. Hochsch., Diss., 2009"]},{"key":"dc:title","label":"Title","values":["Die Ventilation mit biphasic positive airway pressure (BIPAP) im experimentellen akuten Lungenschaden : der Einfluß des transpulmonalen Drucks auf Gasaustausch und Hämodynamik"]}]}],"canonical_facts":{"dc:contributor":["Autschbach, Rüdiger"],"dc:coverage":["DE"],"dc:creator":["Hatam, Nima"],"dc:date":["2009"],"dc:description":["OBJECTIVE: We investigated whether improvement in ventilation perfusion distribution during mechanical ventilation using biphasic positive airway pressure (BIPAP) with spontaneous breathing may be attributed to an effectively increased transpulmonary pressure (PTP) and can also be achieved by increasing PTP during controlled ventilation. DESIGN: In 12 pigs with saline lavage-induced lung injury we compared the effects of BIPAP to pressure-controlled ventilation with equal airway pressure (PCVAW) or equal transpulmonary pressure (PCVTP) on ventilation perfusion distribution assessed by the multiple inert gas elimination technique (MIGET).Measurements and results: Intrapulmonary shunt was 33±11% during BIPAP, 36±10% during PCVAW and 33±15% during PCVTP (p= n.s.). BIPAP resulted in higher PaO2 than PCVAW (188±83 versus 147±82 mmHg, p<0.05), but not than PCVTP (187±139 mmHg). Oxygen delivery was significantly higher during BIPAP (530±109 ml/min) versus 374±113 ml/min during PCVAW and 353±93 ml/min during PCVTP (p<0.005). Tidal volume with PCVTP increased to 11.9±2.3 ml/kg, compared to 8.5±0.8 with BIPAP and 7.6±1.4 with PCVAW (p<0.001) and cardiac output decreased to 3.5±0.6 l/min (BIPAP 4.9±0.8 and PCVAW 3.9±0.8, p<0.006). CONCLUSIONS: In experimental lung injury, BIPAP with preserved spontaneous breathing was effective in increasing regional PTP, since pressure-controlled ventilation with the same PTP resulted in similar gas exchange effects. However, PCVTP caused increased airway pressures and tidal volumes, whereby, with BIPAP, less depression of oxygen delivery and cardiac output were observed. BIPAP could be useful in maintaining pulmonary gas exchange and slightly improving oxygenation without interfering with circulation as strongly as PCV does."],"dc:identifier":["https://publications.rwth-aachen.de/record/51200","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113512%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-27238"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 47 S. : graph. Darst. (2009). = Aachen, Techn. Hochsch., Diss., 2009"],"dc:subject":["info:eu-repo/classification/ddc/610","Lungenverletzung","Ventilation","Gasaustausch","Hämodynamik","Medizin","BIPAP","Transpulmonaler Druck","biphasic positive airway pressure"],"dc:title":["Die Ventilation mit biphasic positive airway pressure (BIPAP) im experimentellen akuten Lungenschaden : der Einfluß des transpulmonalen Drucks auf Gasaustausch und Hämodynamik"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:40:33Z"}