{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:51183"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:51183","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Die Beatmung mit niedrigen Tidal-Volumina verbessert die zerebrale Gewebeoxygenierung im experimentellen Tiermodell des akuten Lungenversagens","abstract":"OBJECTIVE: To investigate the effects of different tidal volumes on cerebral tissue oxygenation. DESIGN: Prospective, controlled animal study.SETTING: Animal research facility of a university hospital.INTERVENTIONS: Two conditions were studied in fourteen female pigs with experimental acute lung injury (ALI) induced by surfactant depletion: 1) low tidal volume ventilation (LT) with 6 ml/kg body weight, 2) high tidal volume ventilation (HT) with 12 ml/kg body weight. For each condition, gas exchange, haemodynamics and continuous cerebral tissue oxygen tension (ptiO2) were analyzed. After induction of ALI, data was collected at 2, 4 and 8 h.MEASUREMENTS AND RESULTS: At baseline, no differences between the groups were found. After induction of ALI, ptiO2 showed a trend towards decreased oxygenation in the HT-group (1.9 ± 3.1 mmHg vs. 8.1 ± 8.7 mmHg, NS). 2, 4 and 8 h after induction of ALI, ptiO2 was significantly lower in the HT-group. paO2 showed no significant differences between the groups at all time points.CONCLUSION: Protective ventilation with low tidal volumes yielded a significant improvement in cerebral tissue oxygenation compared to high tidal volume ventilation. There was dissociation between arterial and cerebral tissue oxygenation.","abstract_html":"OBJECTIVE: To investigate the effects of different tidal volumes on cerebral tissue oxygenation. DESIGN: Prospective, controlled animal study.SETTING: Animal research facility of a university hospital.INTERVENTIONS: Two conditions were studied in fourteen female pigs with experimental acute lung injury (ALI) induced by surfactant depletion: 1) low tidal volume ventilation (LT) with 6 ml/kg body weight, 2) high tidal volume ventilation (HT) with 12 ml/kg body weight. For each condition, gas exchange, haemodynamics and continuous cerebral tissue oxygen tension (ptiO2) were analyzed. After induction of ALI, data was collected at 2, 4 and 8 h.MEASUREMENTS AND RESULTS: At baseline, no differences between the groups were found. After induction of ALI, ptiO2 showed a trend towards decreased oxygenation in the HT-group (1.9 ± 3.1 mmHg vs. 8.1 ± 8.7 mmHg, NS). 2, 4 and 8 h after induction of ALI, ptiO2 was significantly lower in the HT-group. paO2 showed no significant differences between the groups at all time points.CONCLUSION: Protective ventilation with low tidal volumes yielded a significant improvement in cerebral tissue oxygenation compared to high tidal volume ventilation. There was dissociation between arterial and cerebral tissue oxygenation.","abstract_has_math":false,"creators":["Eisenbeis, Andrea Maria"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Kuhlen, Ralf"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009","date_published":"2009","updated_at":"2026-07-30T19:40:33Z","subjects":["info:eu-repo/classification/ddc/610","ARDS","Medizin"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113495%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113495%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113495%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/51183","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A51183","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kuhlen, Ralf"]},{"key":"dc:creator","label":"Author","values":["Eisenbeis, Andrea Maria"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2009"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-28298"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","ARDS","Medizin"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/51183","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113495%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["OBJECTIVE: To investigate the effects of different tidal volumes on cerebral tissue oxygenation. DESIGN: Prospective, controlled animal study.SETTING: Animal research facility of a university hospital.INTERVENTIONS: Two conditions were studied in fourteen female pigs with experimental acute lung injury (ALI) induced by surfactant depletion: 1) low tidal volume ventilation (LT) with 6 ml/kg body weight, 2) high tidal volume ventilation (HT) with 12 ml/kg body weight. For each condition, gas exchange, haemodynamics and continuous cerebral tissue oxygen tension (ptiO2) were analyzed. After induction of ALI, data was collected at 2, 4 and 8 h.MEASUREMENTS AND RESULTS: At baseline, no differences between the groups were found. After induction of ALI, ptiO2 showed a trend towards decreased oxygenation in the HT-group (1.9 ± 3.1 mmHg vs. 8.1 ± 8.7 mmHg, NS). 2, 4 and 8 h after induction of ALI, ptiO2 was significantly lower in the HT-group. paO2 showed no significant differences between the groups at all time points.CONCLUSION: Protective ventilation with low tidal volumes yielded a significant improvement in cerebral tissue oxygenation compared to high tidal volume ventilation. There was dissociation between arterial and cerebral tissue oxygenation."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University 3, 56 Bl. (2009). = Aachen, Techn. Hochsch., Diss., 2009"]},{"key":"dc:title","label":"Title","values":["Die Beatmung mit niedrigen Tidal-Volumina verbessert die zerebrale Gewebeoxygenierung im experimentellen Tiermodell des akuten Lungenversagens"]}]}],"canonical_facts":{"dc:contributor":["Kuhlen, Ralf"],"dc:coverage":["DE"],"dc:creator":["Eisenbeis, Andrea Maria"],"dc:date":["2009"],"dc:description":["OBJECTIVE: To investigate the effects of different tidal volumes on cerebral tissue oxygenation. DESIGN: Prospective, controlled animal study.SETTING: Animal research facility of a university hospital.INTERVENTIONS: Two conditions were studied in fourteen female pigs with experimental acute lung injury (ALI) induced by surfactant depletion: 1) low tidal volume ventilation (LT) with 6 ml/kg body weight, 2) high tidal volume ventilation (HT) with 12 ml/kg body weight. For each condition, gas exchange, haemodynamics and continuous cerebral tissue oxygen tension (ptiO2) were analyzed. After induction of ALI, data was collected at 2, 4 and 8 h.MEASUREMENTS AND RESULTS: At baseline, no differences between the groups were found. After induction of ALI, ptiO2 showed a trend towards decreased oxygenation in the HT-group (1.9 ± 3.1 mmHg vs. 8.1 ± 8.7 mmHg, NS). 2, 4 and 8 h after induction of ALI, ptiO2 was significantly lower in the HT-group. paO2 showed no significant differences between the groups at all time points.CONCLUSION: Protective ventilation with low tidal volumes yielded a significant improvement in cerebral tissue oxygenation compared to high tidal volume ventilation. There was dissociation between arterial and cerebral tissue oxygenation."],"dc:identifier":["https://publications.rwth-aachen.de/record/51183","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113495%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-28298"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University 3, 56 Bl. (2009). = Aachen, Techn. Hochsch., Diss., 2009"],"dc:subject":["info:eu-repo/classification/ddc/610","ARDS","Medizin"],"dc:title":["Die Beatmung mit niedrigen Tidal-Volumina verbessert die zerebrale Gewebeoxygenierung im experimentellen Tiermodell des akuten Lungenversagens"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:40:33Z"}