{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:50797"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:50797","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Der Einfluss von pdHGF auf die Wundheilung","abstract":"The pleiotropic growth factor HGF ist known for its various effects on different target cells. Depending on the target organ the binding process of HGF to its transmembrane receptor Met can induce angiogenesis, mitogenesis, anti-apoptosis, morphogenesis as well as motogenesis. Therefore HGF is essential for the development, proliferation and regeneration of different organs and is also an important cytokine for cutanous wound healing. Hitherto existing studies assume that a treatment with recombinant produced rHGF is therapeutically significant for the therapy of chronical wounds accelerating the wound healing process. So far the impact of patient derived pdHGF on wound healing has been unknown. The fact that pdHGF has a higher molecular weight than rHGF leads to the assumption that pdHGF is more stable. That is why the purpose of this study focused on the effects of pdHGF on cutaneous wound healing. Using a diabetical mouse model, our first experimental model examined the influence of topical application on pdHGF on an impaired wound healing. Focussing on the effectiveness of pdHGF in a physiological organism, C57/BL6 mice were used in our second experimental model. Therefore pdHGF was injected subcutaneously in order to find out its impact on hair growth as a indicator for cell proliferation and regeneration. For the first time, our study highlights that pdHGF is able to accelerate wound healing significantly. This effects was also confirmed for rHGF. Concerning the design of this study, we divided the wound healing process into five periods of time in order to simplify its allocation towards the different stages of wound healing. Our results showed that a treatment with pdHGF accelerates wound healing between day 13 to day 16 (fourth period) the most. Besides that, these wounds showed an improved structure of skin. Towards the end of these experiments, wounds treated with pdHGF showed less rigid collagen fibers leading to a more flexible skin structure. This might suggest that a treatment with pdHGF is able to reconstruct most of the physiological skin structure and its natural function. Follow-up studies should focus on these aspects, which could influence the development of future therapeutical strategies concerning the treatment of chronical wound healing. Furthermore, our results show that significant lower HGF concentrations can be used for the treatment of chronical wounds. In addition to that, our study points at the fact that rHGF plays a major role in accelerating hair growth which could lead to the development of new therapeutical alternatives concerning hair diseases.","abstract_html":"The pleiotropic growth factor HGF ist known for its various effects on different target cells. Depending on the target organ the binding process of HGF to its transmembrane receptor Met can induce angiogenesis, mitogenesis, anti-apoptosis, morphogenesis as well as motogenesis. Therefore HGF is essential for the development, proliferation and regeneration of different organs and is also an important cytokine for cutanous wound healing. Hitherto existing studies assume that a treatment with recombinant produced rHGF is therapeutically significant for the therapy of chronical wounds accelerating the wound healing process. So far the impact of patient derived pdHGF on wound healing has been unknown. The fact that pdHGF has a higher molecular weight than rHGF leads to the assumption that pdHGF is more stable. That is why the purpose of this study focused on the effects of pdHGF on cutaneous wound healing. Using a diabetical mouse model, our first experimental model examined the influence of topical application on pdHGF on an impaired wound healing. Focussing on the effectiveness of pdHGF in a physiological organism, C57/BL6 mice were used in our second experimental model. Therefore pdHGF was injected subcutaneously in order to find out its impact on hair growth as a indicator for cell proliferation and regeneration. For the first time, our study highlights that pdHGF is able to accelerate wound healing significantly. This effects was also confirmed for rHGF. Concerning the design of this study, we divided the wound healing process into five periods of time in order to simplify its allocation towards the different stages of wound healing. Our results showed that a treatment with pdHGF accelerates wound healing between day 13 to day 16 (fourth period) the most. Besides that, these wounds showed an improved structure of skin. Towards the end of these experiments, wounds treated with pdHGF showed less rigid collagen fibers leading to a more flexible skin structure. This might suggest that a treatment with pdHGF is able to reconstruct most of the physiological skin structure and its natural function. Follow-up studies should focus on these aspects, which could influence the development of future therapeutical strategies concerning the treatment of chronical wound healing. Furthermore, our results show that significant lower HGF concentrations can be used for the treatment of chronical wounds. In addition to that, our study points at the fact that rHGF plays a major role in accelerating hair growth which could lead to the development of new therapeutical alternatives concerning hair diseases.","abstract_has_math":false,"creators":["Kühlmann, Britta Anna"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Pallua, Norbert"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-30T19:40:25Z","subjects":["info:eu-repo/classification/ddc/610","Hepatozyten-Wachstumsfaktor","C-met-Rezeptor","Wundheilung","Regeneration","Haarwuchs","Medizin","chronische Wunde","hepatocyte growth factor","tissue regeneration","Met","wound healing","hair growth"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113324%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113324%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113324%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/50797","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50797","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Pallua, Norbert"]},{"key":"dc:creator","label":"Author","values":["Kühlmann, Britta Anna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2012"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-42927"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Hepatozyten-Wachstumsfaktor","C-met-Rezeptor","Wundheilung","Regeneration","Haarwuchs","Medizin","chronische Wunde","hepatocyte growth factor","tissue regeneration","Met","wound healing","hair growth"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/50797","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113324%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The pleiotropic growth factor HGF ist known for its various effects on different target cells. Depending on the target organ the binding process of HGF to its transmembrane receptor Met can induce angiogenesis, mitogenesis, anti-apoptosis, morphogenesis as well as motogenesis. Therefore HGF is essential for the development, proliferation and regeneration of different organs and is also an important cytokine for cutanous wound healing. Hitherto existing studies assume that a treatment with recombinant produced rHGF is therapeutically significant for the therapy of chronical wounds accelerating the wound healing process. So far the impact of patient derived pdHGF on wound healing has been unknown. The fact that pdHGF has a higher molecular weight than rHGF leads to the assumption that pdHGF is more stable. That is why the purpose of this study focused on the effects of pdHGF on cutaneous wound healing. Using a diabetical mouse model, our first experimental model examined the influence of topical application on pdHGF on an impaired wound healing. Focussing on the effectiveness of pdHGF in a physiological organism, C57/BL6 mice were used in our second experimental model. Therefore pdHGF was injected subcutaneously in order to find out its impact on hair growth as a indicator for cell proliferation and regeneration. For the first time, our study highlights that pdHGF is able to accelerate wound healing significantly. This effects was also confirmed for rHGF. Concerning the design of this study, we divided the wound healing process into five periods of time in order to simplify its allocation towards the different stages of wound healing. Our results showed that a treatment with pdHGF accelerates wound healing between day 13 to day 16 (fourth period) the most. Besides that, these wounds showed an improved structure of skin. Towards the end of these experiments, wounds treated with pdHGF showed less rigid collagen fibers leading to a more flexible skin structure. This might suggest that a treatment with pdHGF is able to reconstruct most of the physiological skin structure and its natural function. Follow-up studies should focus on these aspects, which could influence the development of future therapeutical strategies concerning the treatment of chronical wound healing. Furthermore, our results show that significant lower HGF concentrations can be used for the treatment of chronical wounds. In addition to that, our study points at the fact that rHGF plays a major role in accelerating hair growth which could lead to the development of new therapeutical alternatives concerning hair diseases."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University VIII, 107 S. : Ill., graph. Darst. (2012). = Aachen, Techn. Hochsch., Diss., 2012"]},{"key":"dc:title","label":"Title","values":["Der Einfluss von pdHGF auf die Wundheilung"]}]}],"canonical_facts":{"dc:contributor":["Pallua, Norbert"],"dc:coverage":["DE"],"dc:creator":["Kühlmann, Britta Anna"],"dc:date":["2012"],"dc:description":["The pleiotropic growth factor HGF ist known for its various effects on different target cells. Depending on the target organ the binding process of HGF to its transmembrane receptor Met can induce angiogenesis, mitogenesis, anti-apoptosis, morphogenesis as well as motogenesis. Therefore HGF is essential for the development, proliferation and regeneration of different organs and is also an important cytokine for cutanous wound healing. Hitherto existing studies assume that a treatment with recombinant produced rHGF is therapeutically significant for the therapy of chronical wounds accelerating the wound healing process. So far the impact of patient derived pdHGF on wound healing has been unknown. The fact that pdHGF has a higher molecular weight than rHGF leads to the assumption that pdHGF is more stable. That is why the purpose of this study focused on the effects of pdHGF on cutaneous wound healing. Using a diabetical mouse model, our first experimental model examined the influence of topical application on pdHGF on an impaired wound healing. Focussing on the effectiveness of pdHGF in a physiological organism, C57/BL6 mice were used in our second experimental model. Therefore pdHGF was injected subcutaneously in order to find out its impact on hair growth as a indicator for cell proliferation and regeneration. For the first time, our study highlights that pdHGF is able to accelerate wound healing significantly. This effects was also confirmed for rHGF. Concerning the design of this study, we divided the wound healing process into five periods of time in order to simplify its allocation towards the different stages of wound healing. Our results showed that a treatment with pdHGF accelerates wound healing between day 13 to day 16 (fourth period) the most. Besides that, these wounds showed an improved structure of skin. Towards the end of these experiments, wounds treated with pdHGF showed less rigid collagen fibers leading to a more flexible skin structure. This might suggest that a treatment with pdHGF is able to reconstruct most of the physiological skin structure and its natural function. Follow-up studies should focus on these aspects, which could influence the development of future therapeutical strategies concerning the treatment of chronical wound healing. Furthermore, our results show that significant lower HGF concentrations can be used for the treatment of chronical wounds. In addition to that, our study points at the fact that rHGF plays a major role in accelerating hair growth which could lead to the development of new therapeutical alternatives concerning hair diseases."],"dc:identifier":["https://publications.rwth-aachen.de/record/50797","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113324%22"],"dc:language":["ger"],"dc:publisher":["Publikationsserver der RWTH Aachen University"],"dc:relation":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-42927"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:source":["Aachen : Publikationsserver der RWTH Aachen University VIII, 107 S. : Ill., graph. Darst. (2012). = Aachen, Techn. Hochsch., Diss., 2012"],"dc:subject":["info:eu-repo/classification/ddc/610","Hepatozyten-Wachstumsfaktor","C-met-Rezeptor","Wundheilung","Regeneration","Haarwuchs","Medizin","chronische Wunde","hepatocyte growth factor","tissue regeneration","Met","wound healing","hair growth"],"dc:title":["Der Einfluss von pdHGF auf die Wundheilung"],"dc:type":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-30T19:40:25Z"}