Vergleich zweier Kontrastmittel in der kernspintomographischen Vitalitätsdiagnostik des Myokards

Within clinical routine examinations we performed a study containing 60 patients undergoing a 1,5 Tesla MR imaging of cardiac vitality. By using a standardized protocol cine images were gathered by a true-FISP-sequence and late enhancement images with IR turbo-Flash-sequence. Look locker sequences were also measured. MR imaging was gathered of 30 patients receiving 0,2 mmol/kg KG Gd-DTPA and 30 patients receiving 0,1 mmol/kg KG Gd-BOPTA. Each group consisted of 26 patients with myocardial infarction. T1 values were measured in left ventricular myocardium, left ventricular cavity, infarcted myocardium, subcutaneous fat tissue and skeletal muscle both in native look locker images and after administration of the agent 3 and 25 minutes later. After determination of signal intensities of late enhancement images in left ventricular myocardium, blood and infracted myocardium, contrast was calculated. Qualities of late enhancement images were assessed. In addition the size of infracted area, myocardial thickness and transmurality were collected. The main results are:(1) T1 values of infarcted myocardium 3 and 25 minutes after injection of agent were significantly lower using a double dose of Gd-DTPA than using a single dose of Gd-BOPTA. However values in noninfarcted myocardium showed no differences. T1 values in left ventricular cavity after 3 minutes were lower after application of Gd-DTPA. There was no difference after 25 minutes.(2) Contrast between vital myocardium and infarcted myocardium was higher after administration of a double dose of Gd-DTPA. Using Gd-DTPA signal intensities in left ventricular cavity did not differ from those in infarcted myocardium. Using Gd-BOPTA they were significantly higher in left ventricular cavity than in infarcted myocardium.(3) The Quality of late enhancement images was equal for both agents. In conclusion a single dose of Gd-BOPTA is capable for cardiac MR imaging vitality diagnostics. Further studies using additional MR techniques to decrease signal intensities in blood should be conducted.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2009

Author dc:creator

• Hahnen, Christa

Contributors dc:contributor

• Krombach, Gabriele

• info:eu-repo/classification/ddc/610
• Vitalität
• NMR-Tomographie
• Herzinfarkt
• Kontrastmittel
• Medizin
• Gd-BOPTA
• Gd-DTPA
• Look Locker
• late enhancement

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113203%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50668