{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:50560"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:50560","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Zur Problematik der Schwellenwertbestimmung von Bleiwerten im Blut : Ergebnisse einer umweltmedizinischen Querschnittserhebung","abstract":"Lead is an environmental toxin which causes injuries of the human organism as well as of the central nervous system (CNS). In the past, research in this context was mostly related to investigations of persons who were heavily exposed to lead, especially children with increased measurable lead blood concentrations. It was shown in different studies that lead contaminations lead to irreversible intelligence deficits for children. In addition, lead can reduce the concentration capabilities and the scholar performance (mathematical, memory and reading skills) as well as lead to reduced coordination and fine motor skills. In recent publications, it was also shown that weak lead contaminations of children (< 10 µg/dl limit as defined by WHO) cause damages of the central nervous system. However, it is still unknown in how far weak lead contaminations damage the central nervous system of adult people. In this thesis, the influence of weak lead contaminations of adults was investigated in the context of the achievable attentiveness. For this purpose, 50 test persons who suffered from environmental diseases were examined in detailed medical tests during the time period between April 1997 and December 1997 in the environmental ambulance of the Klinikum Aachen. In the course of these tests, especially the lead concentration in the blood and the urine of the test persons were screened for heavy metals and selenium. Based on a standardized set of neurological tests specific attention capabilities of the test persons were assessed. As a result, it was shown that a significant correlation between the lead concentration in the blood and the speed of the human working memory exists. Lead has a negative impact already for low levels of contamination and yields measurable cognitive degenerations. The observed degradations indicate that constant weak lead contaminations affect the pre-frontal cortex which is connected to the working memory performance. Other disorders described by the test persons may also be influenced by lead contaminations. A proof for this, however, can not be provided by the involved test methods.","abstract_html":"Lead is an environmental toxin which causes injuries of the human organism as well as of the central nervous system (CNS). In the past, research in this context was mostly related to investigations of persons who were heavily exposed to lead, especially children with increased measurable lead blood concentrations. It was shown in different studies that lead contaminations lead to irreversible intelligence deficits for children. In addition, lead can reduce the concentration capabilities and the scholar performance (mathematical, memory and reading skills) as well as lead to reduced coordination and fine motor skills. In recent publications, it was also shown that weak lead contaminations of children (&lt; 10 µg/dl limit as defined by WHO) cause damages of the central nervous system. However, it is still unknown in how far weak lead contaminations damage the central nervous system of adult people. In this thesis, the influence of weak lead contaminations of adults was investigated in the context of the achievable attentiveness. For this purpose, 50 test persons who suffered from environmental diseases were examined in detailed medical tests during the time period between April 1997 and December 1997 in the environmental ambulance of the Klinikum Aachen. In the course of these tests, especially the lead concentration in the blood and the urine of the test persons were screened for heavy metals and selenium. Based on a standardized set of neurological tests specific attention capabilities of the test persons were assessed. As a result, it was shown that a significant correlation between the lead concentration in the blood and the speed of the human working memory exists. Lead has a negative impact already for low levels of contamination and yields measurable cognitive degenerations. The observed degradations indicate that constant weak lead contaminations affect the pre-frontal cortex which is connected to the working memory performance. Other disorders described by the test persons may also be influenced by lead contaminations. A proof for this, however, can not be provided by the involved test methods.","abstract_has_math":false,"creators":["Krüger, Kirsten"],"institution":"Publikationsserver der RWTH Aachen University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Kunert, Hanns Jürgen"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-30T19:40:25Z","subjects":["info:eu-repo/classification/ddc/610","Aufmerksamkeit","Blei","Arbeitsgedächtnis","Schwellenwert","Medizin","alertness","lead","threshold","working memory"],"languages":["ger"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113100%22"],"render_values":[{"text":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113100%22","href":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113100%22","code":true}]}]},"links":{"outbound_url":"https://publications.rwth-aachen.de/record/50560","outbound_label":"Repository record","outbound_source":"dc:identifier"},"source_record":{"url":"https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50560","prefix":"oai_dc"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Kunert, Hanns Jürgen"]},{"key":"dc:creator","label":"Author","values":["Krüger, Kirsten"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:coverage","label":"Dc Coverage","values":["DE"]},{"key":"dc:date","label":"Dc Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["Publikationsserver der RWTH Aachen University"]},{"key":"dc:relation","label":"Dc Relation","values":["info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-26373"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/610","Aufmerksamkeit","Blei","Arbeitsgedächtnis","Schwellenwert","Medizin","alertness","lead","threshold","working memory"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["ger"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://publications.rwth-aachen.de/record/50560","https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113100%22"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Lead is an environmental toxin which causes injuries of the human organism as well as of the central nervous system (CNS). In the past, research in this context was mostly related to investigations of persons who were heavily exposed to lead, especially children with increased measurable lead blood concentrations. It was shown in different studies that lead contaminations lead to irreversible intelligence deficits for children. In addition, lead can reduce the concentration capabilities and the scholar performance (mathematical, memory and reading skills) as well as lead to reduced coordination and fine motor skills. In recent publications, it was also shown that weak lead contaminations of children (< 10 µg/dl limit as defined by WHO) cause damages of the central nervous system. However, it is still unknown in how far weak lead contaminations damage the central nervous system of adult people. In this thesis, the influence of weak lead contaminations of adults was investigated in the context of the achievable attentiveness. For this purpose, 50 test persons who suffered from environmental diseases were examined in detailed medical tests during the time period between April 1997 and December 1997 in the environmental ambulance of the Klinikum Aachen. In the course of these tests, especially the lead concentration in the blood and the urine of the test persons were screened for heavy metals and selenium. Based on a standardized set of neurological tests specific attention capabilities of the test persons were assessed. As a result, it was shown that a significant correlation between the lead concentration in the blood and the speed of the human working memory exists. Lead has a negative impact already for low levels of contamination and yields measurable cognitive degenerations. The observed degradations indicate that constant weak lead contaminations affect the pre-frontal cortex which is connected to the working memory performance. Other disorders described by the test persons may also be influenced by lead contaminations. A proof for this, however, can not be provided by the involved test methods."]},{"key":"dc:source","label":"Dc Source","values":["Aachen : Publikationsserver der RWTH Aachen University IV, 90 S. (2008). = Aachen, Techn. Hochsch., Diss., 2008"]},{"key":"dc:title","label":"Title","values":["Zur Problematik der Schwellenwertbestimmung von Bleiwerten im Blut : Ergebnisse einer umweltmedizinischen Querschnittserhebung"]}]}],"canonical_facts":{"dc:contributor":["Kunert, Hanns Jürgen"],"dc:coverage":["DE"],"dc:creator":["Krüger, Kirsten"],"dc:date":["2008"],"dc:description":["Lead is an environmental toxin which causes injuries of the human organism as well as of the central nervous system (CNS). In the past, research in this context was mostly related to investigations of persons who were heavily exposed to lead, especially children with increased measurable lead blood concentrations. 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In the course of these tests, especially the lead concentration in the blood and the urine of the test persons were screened for heavy metals and selenium. Based on a standardized set of neurological tests specific attention capabilities of the test persons were assessed. As a result, it was shown that a significant correlation between the lead concentration in the blood and the speed of the human working memory exists. Lead has a negative impact already for low levels of contamination and yields measurable cognitive degenerations. The observed degradations indicate that constant weak lead contaminations affect the pre-frontal cortex which is connected to the working memory performance. Other disorders described by the test persons may also be influenced by lead contaminations. 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