Tierexperimentelle Erprobung eines vollständig implantierbaren, telemetrisch arbeitenden intraokularen Drucksensors

Glaucoma is a disease of the eye which progression is depending on the intraocular pressure. The gold standard of measuring the intraocular pressure is the Goldmann applantation tonometer. This system can only used by educated ophthalmologists. By now there is no system that can offer an uncomplicated measure of the intraocular pressure at close intervals without a high instrument-based complexity. Systems that can be handled by the patient himself exist but they are not reliably working. A system that allows a continuous or high frequent measurement of the intraocular pressure independent from influence by different examiners would be desirable for an efficient management of glaucoma. We proved the practicability of a new developed system to record the intraocular pressure directly. It consists of an inductive pressure sensor that is completely integrated in an intraocular lens and communicates telemetric with an external readout device. This system was implanted in rabbit’s eyes like common artificial intraocular lenses. Over a time of three months we recorded the pressure that was measured by the sensor and compared the values with the pressure values recorded with a common tonometer. We evaluated the complexity of the implantation, the correlation of the values measured by the pressure sensor and the common tonometer and the practicability of the external readout device. The results show that the intraocular pressure sensor can be implanted in the same technique like common intraocular lenses. The precision of the values registered by the intraocular pressure sensor are not up to the standards that are demanded for a measuring system for medical purposes. We found correlations to the reference system with a maximum of 0,61292. Such a correlation can not be accepted when the measure should lead to a direct therapeutical consequence. Reason for the bad performance of the pressure measuring system is probably a less sealed encapsulation of the pressure recording elements of the system. After explantation we found steam bubbles on all of the pressure recording elements, potentially caused by microscopic lesions during the folding process for the implantation. This could be corrected by a better encapsulation of the whole system, maybe with the use of another material. The measurement itself using the external readout device was uncomplicated. Also untrained person were capable to perform repeated measures after a short introduction. In a summary it is to say that the practical performance of the intraocular pressure sensor in implantation as well as in handling the external readout device is satisfying. But the bad correlation of the pressure values measured by the system and compared with the common tonometer is not acceptable.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2008

Author dc:creator

• Schneider, Kai Henrik

Contributors dc:contributor

• Walter, Peter

• info:eu-repo/classification/ddc/610
• Tonometer
• Augendruck
• Telemetrie
• Glaukom
• Drucksensor
• Medizin
• tonometry
• intraocular pressure
• telemetry
• glaucoma

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-113027%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50484