Der Einfluss der Schnittführung auf die Anastomosenheilung am Dünn- und Dickdarm

The influence on the postoperative woundhealing of the incisional location/direction as well as the suture used in bowel surgery are factors that often determine the postoperative outcome of the procedure. One of the greatest and most devastating complications the surgeon faces is the postoperative insufficiency of the suture or anastomosis with quite considerable morbidity and letality rates. The postoperative insufficiency of the suture or anastomosis is a multifactorial issue that comprises of many surgical details as well as complex mechanisms of the woundhealing on a molecular level. The influence of the incisional location and technic (enterotomy, anastomosis) is still a matter of controversial discussion. For this reason, primary purpose of the thesis is to shed light on the above issue and thus bring any heated debate, relative to above matter, to an end. Taken into consideration important factors of the woundhealing of the small as well as large bowel (tissue perfusion, expression of kollagen, expression of Ki-67, expression of MMPs, configuration of the villi) it could be shown that the two surgical technics in question (enterotomie, anastomosis) do not substantially differ from each other. Similar results were observed regarding the suture technic. Specifically, there was not a single suture- or anastomosis-insufficiency noticed amongst the animals operated. This in turn leads to the coclusion that as far as the laboratory mice are concerned the two operation technics are qualitatively equal. Still, it remains to be proven on broader clinical trials whether these results can be verified on humans as well.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2008

Author dc:creator

• Chronopoulos, Argyrios

Contributors dc:contributor

• Schumpelick, Volker

• info:eu-repo/classification/ddc/610
• Darmchirurgie
• Medizin
• Bowelsurgery

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-112772%22

OAI record oai:identifier

https://publications.rwth-aachen.de/oai2d?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Apublications.rwth-aachen.de%3A50218