{"id":{"repo_id":"aachen","oai_identifier":"oai:publications.rwth-aachen.de:50076"},"canonical_url":"https://search.dev.ndltd.org/etd/aachen/oai:publications.rwth-aachen.de:50076","repository":{"repo_id":"aachen","name":"RWTH Aachen University","base_url":"https://publications.rwth-aachen.de/oai2d"},"display":{"title":"Entwicklung und Erweiterung von organokatalytischen Domino-Reaktionen","abstract":"An organocatalytic quadruple-cascade-reaction between Acetaldehyde and aromatic Nitrostyrenes has been developed. This reaction was conducted in a microwave oven with THF as solvent. The additive was water. With diphenylprolinol-TMS-ether as catalyst, several examples of trisubstituted cyclohexenecarbaldehydes with yileds between 25-45% and ee between 89-99% were synthesized. The diastereomeric ratio was between 1.4:1 and 3.5:1. Another topic was the expansion of a known triplecascade-reaction. This should be expanded via Diels-Alder-Reactions. Therefore, the aldehydes were derivatized with esterlinkages. In a subsequent step, the Diels-Alder-Reactions should be carried out by heating or under catalysis of Lewis-acids. This was not succesful. The third topic was a organocatalytic Tandem-Reaction (Michael/Horner) between a nitrophosphonate and an unsaturated aldehyde. The resulting cyclohexene ester were obtained with yields up to 33% and an ee up to 92%.","abstract_html":"An organocatalytic quadruple-cascade-reaction between Acetaldehyde and aromatic Nitrostyrenes has been developed. This reaction was conducted in a microwave oven with THF as solvent. The additive was water. With diphenylprolinol-TMS-ether as catalyst, several examples of trisubstituted cyclohexenecarbaldehydes with yileds between 25-45% and ee between 89-99% were synthesized. The diastereomeric ratio was between 1.4:1 and 3.5:1. Another topic was the expansion of a known triplecascade-reaction. This should be expanded via Diels-Alder-Reactions. Therefore, the aldehydes were derivatized with esterlinkages. In a subsequent step, the Diels-Alder-Reactions should be carried out by heating or under catalysis of Lewis-acids. This was not succesful. The third topic was a organocatalytic Tandem-Reaction (Michael/Horner) between a nitrophosphonate and an unsaturated aldehyde. 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